Xavier Duval

Identification and functional characterization of regulatory variants in DPP9 associated with COVID-19 severity

Gaëlle Farah, Magali Torres, Léo Henches, Hugues Aschard et autres

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to a wide-range of clinical outcomes, which have been extensively studied through genome-wide association studies (GWAS). METHODS: Starting from lead genetic variants associated with COVID-19 infection and severity, we identified a subset …

fr, us (code pays fourni par la source)

A multimodal AI model combining imaging, clinical and biological data significantly outperformed CXR-based AI diagnosis in pneumonia

Jérémy Hofmeister, Nicolás Garin, Alexandra Platon, Max Scheffler et autres

Background Current AI models that rely solely on chest radiographs (CXRs) or clinical and biological data have limitations. Our goal was to determine if incorporating clinical and biological data to CXR data improved accuracy in the diagnosis of pneumonia. Methods This retrospective …

ch, fr, mc, us (code pays fourni par la source)

Diagnostic performance of 2023 endocarditis criteria in patients with and without cardiac implantable electronic devices

Christine Selton‐Suty, Benoît Lalloué, François Goehringer, François Alla et autres

BACKGROUND: The European Society of Cardiology (ESC) diagnostic criteria for infective endocarditis (IE) were updated in 2023. Using a prospective multicentre cohort of patients treated for IE, we compared the performance of the 2023 ESC classification to that of 2015 ESC, 2019 …

fr, gp (code pays fourni par la source)

Healthcare costs of invasive meningococcal disease: a nationwide population-based study using an innovative clustering method to identify sequelae

Xavier Duval, Cédric Collin, Alexiane Baloche, Laurent Fanchon et autres

BACKGROUND: Studies investigating the costs associated with invasive meningococcal disease (IMD) are scarce, primarily due to the disease rarity, its highly variable prognosis, and the potential for sequelae to develop long after the acute phase. We conducted a retrospective longitudinal cohort study …

fr, gb (code pays fourni par la source)

Cloxacillin versus cefazolin for meticillin-susceptible Staphylococcus aureus bacteraemia (CloCeBa): a prospective, open-label, multicentre, non-inferiority, randomised clinical trial

Charles Burdet, Nadia Saïdani, Céline Dupieux, Adrien Lemaignen et autres

BACKGROUND: Although widely used, cefazolin efficacy for the treatment of meticillin-susceptible Staphylococcus aureus (MSSA) bacteraemia has not thus far been investigated in a clinical trial. In this study, we aimed to compare the efficacy and safety of cefazolin with that of cloxacillin …

fr (code pays fourni par la source)

Endocardite infectieuse

Laurène Deconinck, Xavier Duval

3D imaging cone beam computed tomography versus orthopantomogram to improve the oral health status of patients hospitalized for infective endocarditis (3D STARS): study protocol of a randomized superiority controlled trial

Alexandra Cloître, Xavier Duval, David Boutoille, Morgane Péré et autres

BACKGROUND: Infective endocarditis (IE) is a serious and costly infectious disease associated with high morbidity and mortality. The oral cavity is the second most common source of IE accounting for approximately 30% of cases. Detection and management of oral infectious foci (OIF) …

fr (code pays fourni par la source)

Enquête de pratique sur l'utilisation de l'antibiothérapie suspensive en France dans l'endocardite infectieuse

Robert Eichel, Antonio Addario, T. Lemmet, Laurène Deconinck et autres

Introduction Un traitement anti-infectieux prolongée dit suspensif ou suppressif (TAS) est parfois utilisée après traitement initial de l'endocardite infectieuse (EI), toutefois sans réelles recommandations. Cette enquête vise à établir un état des lieux de cette pratique en France. Matériels et méthodes Un …

fr (code pays fourni par la source)

Efficacité vaccinale COVID-19 2023/2024 chez l'adulte hospitalisé en France : résultats d'une étude prospective en vie réelle

Sébastien Guitton, LH. Lefrançois, Élisabeth Botelho-Nevers, L. Crantelle et autres

fr (code pays fourni par la source)

Cloxacilline versus céfazoline dans les bactériémies à Staphylococcus aureus sensible à la méthicilline (CloCeBa) : un essai randomisé, contrôlé et de non-infériorité

Charles Burdet, Nadia Saïdani, Adrien Lemaignen, Étienne Canouï et autres

fr (code pays fourni par la source)

Healthcare costs of invasive meningococcal disease: a nationwide population-based study using an innovative clustering method to identify sequelae

Xavier Duval, Cédric Collin, Alexiane Baloche, Laurent Fanchon et autres

fr, gb (code pays fourni par la source)

Improvement of the diagnosis of intestinal protozoa using a multiplex qPCR strategy compared to classical microscopy: a prospective study on 3,500 stool samples over 3 years

Florence Robert-Gangneux, Xavier Duval, Clément Cazala, Sorya Belaz et autres

ABSTRACT Commercial multiplex real-time PCR (qPCR assays) are now widely used for the diagnosis of intestinal protozoan infections, but few prospective studies evaluated their performances on large patient cohorts. We extracted data from our information system from 1 January 2021 to 15 …

fr (code pays fourni par la source)