Shoko Ito

Large Cell Neuroendocrine Carcinoma With Acquired Hemophilia A Diagnosed by Endobronchial Biopsy: A Case Report

Kei Yaoita, Toshikazu Takasaki, Shoko Ito, Toshimi Kawahata et autres

Primary lung cancer with acquired hemophilia A is rare. We report a case of large cell neuroendocrine carcinoma (LCNEC) with acquired hemophilia A diagnosed by endobronchial biopsy. A 75-year-old male was admitted to our hospital due to severe anemia and multiple organ …

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[Bickerstaff brainstem encephalitis preceding central nervous system relapse of diffuse large B-cell lymphoma].

Takuto Ishikawa, Masakatsu Kawamura, Junko Takeshita, Shoko Ito et autres

We report the case of a 65-year-old man who was diagnosed with Bickerstaff brainstem encephalitis prior to central nervous system (CNS) relapse of diffuse large B-cell lymphoma (DLBCL). He was diagnosed with DLBCL of the paranasal sinus in June 2022. After treatment …

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2524. Safety and Pharmacokinetics of PA-001, a New Potential COVID-19 Drug That Targets the S2 Subunit of SARS-CoV-2 Spike Protein, in Healthy Subjects

Haruaki Kurasaki, Masaki Ohuchi, Katsuma Matsui, Masatoshi Matsumoto et autres

Abstract Background Frequent emergence of new variants of the SARS-CoV-2 virus continues to be a concern in treatment of COVID-19 infection, despite the approval of several drugs in recent years. To address this problem, we identified a new macrocyclic peptide, PA-001, which …

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Cost-Effectiveness of Anti-BCMA Chimeric Antigen Receptor T Cell Therapy in Relapsed/Refractory Multiple Myeloma

Chihiro Yamamoto, Daisuke Minakata, Daizo Yokoyama, Shuka Furuki et autres

Despite its promising outcomes, anti-BCMA chimeric antigen receptor T cell therapy (CAR-T) is the most expensive myeloma treatment developed to date, and its cost-effectiveness is an important issue. This study aimed to assess the cost-effectiveness of anti-BCMA CAR-T compared to standard antimyeloma …

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Efficacy and safety of the neonatal Fc receptor inhibitor efgartigimod in adults with primary immune thrombocytopenia (ADVANCE IV): a multicentre, randomised, placebo-controlled, phase 3 trial

Catherine M. Broome, David J. Kuter, Hanny T. Al-Samkari, James Bruce Bussel et autres

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Antibody-mediated pathogenesis of chronic GVHD through DBY/HLA class II complexes and induction of a GVL effect

Kento Umino, Kaoru Morita, Takashi Ikeda, Shin‐ichiro Kawaguchi et autres

Chronic graft-versus-host disease (cGVHD) is a multiorgan syndrome with clinical features resembling those of autoimmune diseases. Thus, understanding commonalities in the pathophysiology of cGVHD and autoimmune diseases, such as the presence of disease-risk HLA alleles, is imperative for developing novel therapies against …

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Relapsed and refractory multiple myeloma: A systematic review and network meta‐analysis of the efficacy of novel therapies

Daisuke Minakata, Shin‐ichiro Fujiwara, Daizo Yokoyama, Atsuto Noguchi et autres

Summary The prognosis of multiple myeloma (MM) has dramatically improved with the development of new drugs, and it has become important to determine the appropriate combinations of these novel agents. This study was a systematic review and network meta‐analysis (NMA) of randomized …

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Cost-Effectiveness of Anti-BCMA Chimeric Antigen Receptor T Cell Therapy in Relapsed/ Refractory Multiple Myeloma

Chihiro Yamamoto, Daisuke Minakata, Daizo Yokoyama, Shuka Furuki et autres

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Effect of cumulative daunorubicin dose on cardiotoxicity after allogeneic stem cell transplantation

Shin‐ichiro Fujiwara, Rui Murahashi, Hirotomo Nakashima, Sae Matsuoka et autres

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Radiation Myelopathy Caused by Palliative Radiotherapy and Intrathecal Methotrexate

Yukiko Fukuda, Satoru Takahashi, Michiko Nakamura, Masashi Endo et autres

Radiation myelopathy is a rare, late-stage adverse event that develops following irradiation at or above 50 Gy. Here, we report a case of irreversible paraplegia caused by palliative radiation (20 Gy in 5 fractions) to the spinal cord combined with intrathecal methotrexate …

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Daratumumab in first-line therapy is cost-effective in transplant-eligible patients with newly diagnosed myeloma

Chihiro Yamamoto, Daisuke Minakata, Shunsuke Koyama, Kaoru Sekiguchi et autres

Triplet regimens, such as lenalidomide, bortezomib, and dexamethasone (RVd) or thalidomide, bortezomib, and dexamethasone (VTd), are standard induction therapies for transplant-eligible patients with newly diagnosed multiple myeloma (NDMM). The addition of daratumumab to RVd and VTd has been investigated in the GRIFFIN …

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Clinical interaction between dexamethasone and aprepitant in chemotherapy for lymphoma

Kaoru Hatano, Shin‐ichiro Fujiwara, Kento Umino, Takashi Ikeda et autres

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