Masashi Endo

Association Between EGFR Mutation Status and Out-of-field Recurrence in Locally Advanced Unresectable Non-small Cell Lung Cancer Treated With Chemoradiotherapy and Durvalumab Consolidation

Masashi Endo, YUKIKO FUKUDA, Machi Nakagawa, Kazunari Ogawa et autres

Background/Aim: The efficacy of durvalumab consolidation therapy after chemoradiotherapy (PACIFIC regimen) for patients with epidermal growth factor receptor (EGFR) mutation-positive locally advanced unresectable non-small cell lung cancer (NSCLC) remains unclear. Additionally, data on failure patterns, including in-field recurrence (IFR) and out-of-field recurrence …

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Development of CBCT-Guided Online Adaptive Radiotherapy

Katsuyuki Shirai, Noriko Kishi, Hideaki Hirashima, Masashi Endo et autres

Background: Online adaptive radiotherapy (oART) can change the dose distribution briefly to match the shape of the targets and organs at risk. Cone-beam computed tomography (CBCT)-guided oART has been introduced in clinical practice and is expected to improve clinical outcomes. This technology …

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A Multicenter Phase II Study Evaluating the Efficacy of Single-Fraction 8 Gy Radiotherapy for Bleeding Gastrointestinal Malignancies: STABLE Study Protocol (Preprint)

Shota Miyoshi, Nobuki Imano, Tetsuo Saito, Hiroki Ochi et autres

BACKGROUND Bleeding is a common complication of advanced gastrointestinal malignancies. Although radiotherapy is an effective hemostatic treatment, dose-fractionation remains unclear. Single-fraction 8 Gy radiotherapy has been demonstrated in palliative irradiation for conditions such as bone and liver metastases; however, its effectiveness in …

Gross Tumor Volume as a Predictor of Local Control After Stereotactic Body Radiation Therapy for Bone Oligometastases: A Retrospective Analysis

Uchina Hiya-Kawaguchi, Masashi Endo, Machi Nakagawa, Kazunari Ogawa et autres

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Repeated Abscopal Effect After Two Courses of Stereotactic Body Radiotherapy for Multiple Postoperative Metastases of Malignant Melanoma of the Buccal Mucosa

Masahiro Kawahara, Yukiko Fukuda, Keiko Akahane, Machi Nakagawa et autres

We report a case of repeated abscopal effect (AE) following two courses of stereotactic body radiotherapy (SBRT) for multiple postoperative metastases of malignant melanoma in the buccal mucosa during treatment with nivolumab. A 90-year-old female presented with malignant melanoma of the right …

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Abscopal Effect following Stereotactic Radiation Therapy to the Brain and Spleen in Metastatic Endometrial Cancer: A Case Report

Yukiko Fukuda, Masahiro Kawahara, Keiko Akahane, Machi Nakagawa et autres

Introduction: The abscopal effect of radiation therapy is a rare phenomenon in which immune activation induces the regression of distant, nonirradiated tumors. Recent studies have increasingly suggested that combining radiation therapy with immunotherapy may increase the occurrence rate of the abscopal effect. …

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Efficacy of Radiotherapy for Oligometastatic Lung Cancer and Irradiation Methods Based on Metastatic Site

Katsuyuki Shirai, Masashi Endo, Shuri Aoki, Noriko Kishi et autres

Systemic chemotherapy is a standard treatment for patients with stage IV cancer with distant metastases, and there is little evidence of the effectiveness of local treatments for distant metastatic lesions. However, in recent years, randomized phase II trials targeting oligometastases in lung …

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Palliative radiotherapy for multiple liver metastases of Merkel cell carcinoma: A case report

Masashi Endo, Kazunari Ogawa, Satoru Takahashi, Michiko Nakamura et autres

Introduction: There have been few reports of the efficacy of palliative radiotherapy (RT) for liver metastases of Merkel cell carcinoma (MCC). A case of a patient with gastrointestinal symptoms and liver dysfunction caused by multiple liver metastases of MCC is presented. Palliative …

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Asymptomatic Bladder Stones Exacerbate Acute Genitourinary Adverse Events During Radiation Therapy for Prostate Cancer: Insights From Two Case Reports

Uchina Hiya, Masashi Endo, K Okada, Satoru Takahashi et autres

Background Radiotherapy is a standard treatment for prostate cancer, but it can cause genitourinary (GU) toxicities, such as hematuria, dysuria, urinary retention, and increased urinary frequency. Pre-existing bladder stones may worsen these toxicities, potentially resulting in significant treatment interruptions. Case Presentation Here, …

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Long-Term Outcomes of Radiation Therapy for Pediatric Brain Tumors: A Single-Center Study

Yukiko Fukuda, Masashi Endo, Kazunari Ogawa, Satoru Takahashi et autres

Brain tumors are the leading cause of mortality among pediatric patients. Recent advancements in genetic analysis have facilitated the development of new therapeutic agents, and high-precision radiotherapy techniques have improved survival rates for certain pediatric brain tumors. However, owing to the rarity …

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Changes in Osteoblastic Bone Metastasis Detected Incidentally by Cone-Beam Computed Tomography: A Case Report

Uchina Hiya, Masashi Endo, Kohei Okada, Satoru Takahashi et autres

Introduction: Although cone-beam computed tomography (CBCT) is essential for tumor positioning in image-guided radiotherapy, its diagnostic application is limited by low image quality. This report highlights a case where CBCT unexpectedly detected osteoblastic bone metastasis during radiotherapy for prostate cancer. Case Presentation: …

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Cribriform Pattern Is a Predictive Factor of PSA Recurrence in Patients Receiving Radiotherapy After Prostatectomy

Masahiro Kawahara, Akira Tanaka, Keiko Akahane, Masashi Endo et autres

Background/Aim: In prostate cancer, robotic total prostatectomy is a popular treatment modality. However, prostate-specific antigen (PSA) recurrence after prostate cancer surgery remains a concern. Salvage radiotherapy is commonly used to treat PSA recurrence, but the recurrence rate after salvage radiotherapy is high, …

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