James Sinacore

94. IL-8 and Perceived Stress Differences Associated With IDO1 in Bipolar Disorder

Anton Shkundin, Heather Wheeler, James Sinacore, Angelos Halaris

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79. Genetic Modulation of Tryptophan–Kynurenine Metabolism by IDO1 Variants in Treatment-Resistant Bipolar Depression

Anton Shkundin, Heather Wheeler, James Sinacore, Angelos Halaris

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BDNF blood levels as a potential biomarker Predictor of treatment response and remission in bipolar depression

Anton Shkundin, James Sinacore, Angelos Halaris

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Brain-derived neurotrophic factor and stress perception

Anton Shkundin, Heather E. Wheeler, James Sinacore, Angelos Halaris

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Interleukin-8 is a potential inflammation biomarker in major depressive disorder

Julia L. Versel, Adriana Cantos, Monica Feliz R. Castillo, Evangelia Fatourou et autres

The neuroinflammatory hypothesis of Major Depressive Disorder (MDD) postulates that dysregulated cytokine production is implicated in the etiopathology of the disorder. This study aimed to determine baseline levels of Interleukin-8 (IL-8), an inflammatory cytokine, in MDD and identify possible changes in response …

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166. Arterial Stiffness as an Index of Inflammation in Patients With Treatment Resistant Bipolar Depression

Nausheen Baig, James Sinacore, Angelos Halaris

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103. Correlations Between Brain-Derived Neurotrophic Factor and Perceived Stress in Treatment-Resistant Bipolar Depression

Anton Shkundin, Heather E. Wheeler, James Sinacore, Anna Jevtic et autres

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Modulation of the inflammatory response exerts beneficial effects on anger in treatment-resistant bipolar depression

Angelos Halaris, Ali H. Sayed, Mohammad Hakimi, James Sinacore

: Anger can worsen a person's emotions and increase the severity of an individual's mood state, notably depression. The State-Trait Anger Expression Inventory (STAXI) assessment tool is useful for assessing the experience, expression, and control of anger in normal individuals, and in …

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496. Index of Peripheral Inflammation is Associated With Arterial Stiffness in Treatment-Resistant Bipolar Depression (TRBDD)

Nausheen Baig, James Sinacore, Omer Iqbal, Jawed Fareed et autres

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Elevated Matrix Metalloproteinase 9 in Treatment Resistant Bipolar Depression

Evangelia Fatourou, Alexander TRUONG, Debra Hoppensteadt, Jawed Fareed et autres

Objective: Matrix metalloproteinase is a family of proteases with different pathophysiological roles. Matrix metalloproteinase 9 (MMP9) plays an enzymatic role in the restructuring of the extracellular matrix and adhesion molecules. MMP9 is upregulated in pro-inflammatory states and leads to breakdown of tight …

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Angiogenic Vascular Endothelial Growth Factor (VEGF) Levels Significantly Correlate to Systemic Inflammatory Response Index (SIRI) Measures in Patients with Treatment-Resistant Bipolar Depression Disorder (TRBDD)

Nausheen Baig, James Sinacore, Debra Hoppensteadt, Jawed Fareed et autres

Background: VEGF is a known angiogenic biomarker that is involved in both physiologic and pathologic processes. It has recently been implicated in the stress response and thus, garnered more attention for its role in affective disorders. Its more prominent role in endothelial …

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Cellular Indices and Outcome in Patients with Acute Venous Thromboembolism

Fakiha Siddiqui, Alberto García‐Ortega, Bülent Kantarcıoğlu, James Sinacore et autres

BACKGROUND: Cellular indices provide integrative information about systemic inflammation status which is readily available from routine laboratory parameters. This study aimed to evaluate the prognostic role of three cellular indices in patients with venous thromboembolism (VTE). METHODS: The RIETE registry database was …

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