Cellular Indices and Outcome in Patients with Acute Venous Thromboembolism
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Le résumé fourni par la source
BACKGROUND: Cellular indices provide integrative information about systemic inflammation status which is readily available from routine laboratory parameters. This study aimed to evaluate the prognostic role of three cellular indices in patients with venous thromboembolism (VTE). METHODS: The RIETE registry database was used to determine the association between the baseline neutrophil-to-lymphocyte-ratio (NLR), platelet-to-lymphocyte-ratio (PLR) and systemic-immune-inflammation-index (SII) for 90-day adverse outcomes in patients with acute VTE. RESULTS: From January 2020 to April 2021, 4487 patients with acute VTE were recruited in the RIETE registry. Of these, 2683 presented with symptomatic pulmonary embolism (PE); 283 with incidental PE; 1129 with lower-limb deep vein thrombosis (DVT); 175 with upper-limb DVT; 69 with splanchnic vein thrombosis; 142 with superficial vein thrombosis and 20 with retinal vein thrombosis. Mean values were: NLR 5.9 ± 7.1, PLR 190 ± 158 and SII 1459 ± 2028. During the first 90-days, 38 patients (0.8%) developed recurrent DVT, 45 (1.0%) had recurrent PE, 152 (3.4%) suffered major bleeding, and 484 (11%) died. On multivariable analysis, patients with NLR >4.41 were at an increased risk for major bleeding and patients with NLR >4.96 were at the risk of death, while those with SII >1134.5 were at increased risk for death. CONCLUSIONS: This study reports the results of a large cohort to date which evaluate the prognostic value of three cellular indices simultaneously in patients with acute VTE. Results support that none of the three baseline cellular indices were sufficient for prediction of VTE recurrences in acute VTE patients. The patients with higher baseline NLR values were at an increased risk of major bleeding or death, those with high SII values were only at an increased risk for mortality.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Cellular Indices and Outcome in Patients with Acute Venous Thromboembolism
- Date Crossref
- 01/01/2022
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Loyola University Chicago Department of Pathology & Laboratory Medicine pays non établi dans la noticeUniversité ou école supérieure
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Universidad Católica de Murcia pays non établi dans la noticeUniversité ou école supérieure
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Hospital Universitari i Politècnic La Fe Respiratory Department pays non établi dans la noticeÉtablissement de santé
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Endeavor Health pays non établi dans la noticeÉtablissement de santé
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Hospital General Universitario Gregorio Marañón Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
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Hospital Virgen de la Luz pays non établi dans la noticeÉtablissement de santé
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Hospital de Sant Joan Despí Moisès Broggi pays non établi dans la noticeÉtablissement de santé
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Hospital Universitari Germans Trias i Pujol Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
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Program in Health Sciences pays non établi dans la noticeInstitution
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Evanston NorthShore University Health System. Evanston Department of Medicine and Vascular Medicine pays non établi dans la noticeUniversité ou école supérieure
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Hospital General Virgen de la Luz Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
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Hospital Sant Joan Despí-Moises Broggi Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
Department of Pathology & Laboratory Medicine — Loyola University Chicago, Universidad Católica de Murcia et Respiratory Department — Hospital Universitari i Politècnic La Fe, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.