Lu Xia

A single-tube dual-gene RAA-PfAgo assay for simultaneous detection and identification of PEDV field and vaccine strains

Tao Wang, J Zhang, Hong-bo Cui, Lan‐Lan Zheng et autres

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Immunoproteomic Screening of Candidate Antigens for the Preliminary Development of a Novel Multi-Component and Multi-Epitope Vaccine Against Streptococcus suis Infection

Yue Zhang, Cai‐Ying Li, Yutong Feng, Qibing Gu et autres

Background/Objectives: Streptococcus suis (SS), an important zoonotic pathogen, has caused significant economic losses to the global pig industry. Existing commercial vaccines for SS mainly provide effective protection against a single serotype. Due to the existence of many serotypes and their robust immune …

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Establishment and application of a dual chip digital PCR assay for detection of PDCoV and PEDV

Yue Zhang, Fangting Dong, Yuhang Zhang, Yutong Feng et autres

Introduction: Coinfection with porcine deltacoronavirus (PDCoV) and porcine epidemic diarrhea virus (PEDV) is a major cause of acute diarrhea in piglets, which poses a significant challenge to the swine industry. The early detection and control of these two viruses require highly sensitive …

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Proteomics analysis of PK-15 cells infected with porcine parvovirus and the effect of PCBP1 on PPV replication

Linqing Wang, Yue Song, Menglong Xu, Chi Zhang et autres

Porcine parvovirus (PPV) is one of the most important pathogens that cause reproductive failure in pigs. However, the pathogenesis of PPV infection remains unclear. Proteomics is a powerful tool to understand the interaction between virus and host cells. In the present study, …

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Synthesis and pharmacodynamic evaluation of Dihydropteridone derivatives against PDCoV in vivo and in vitro

Kai Sun, Zhongmou Zhang, Jiani Xing, Shouye Ma et autres

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Isolation and Characterization of Porcine Sapelovirus from the PDCoV-Positive Sample and Its Molecular Epidemiology in Henan Province, China

Yunfei Zhang, Qianqian Li, Lulu Si, Junlong Gao et autres

Porcine sapelovirus (PSV) is an emerging swine enteric virus that can cause various disorders including acute diarrhea, respiratory distress, reproductive failure, and polioencephalomyelitis in pigs. In this study, we isolated a PSV strain HNHB-01 from a clinical porcine deltacoronavirus- (PDCoV-) positive intestinal …

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Preparation of a Single-Chain Antibody against Nucleocapsid Protein of Porcine Deltacoronavirus by Phage Display Technology

Yixuan Zhang, Yue Song, Haojie Ren, Quan Zeng et autres

Porcine deltacoronavirus (PDCoV) mainly causes severe diarrhea and intestinal pathological damage in piglets and poses a serious threat to pig farms. Currently, no effective reagents or vaccines are available to control PDCoV infection. Single-chain fragment variable (scFv) antibodies can effectively inhibit virus …

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Porcine parvovirus induces apopyosis by activating TLR2-mediated NF-κB signaling pathway in PK-15 cells

Lu Xia, Menglong Xu, Xiaohui Jin, Chi Zhang et autres

Abstract Porcine parvovirus (PPV) mainly induces severe reproductive failure in pregnant swine, and causes huge economic losses to the swine industry. Cell apoptosis induced by PPV infection has been identified the major cause of reproductive failure. However, the molecular mechanism was not …

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ELISA, Virus Neutralization, and Immunofluorescence Assays for Detection of Antibodies Against Porcine Deltacoronavirus

Lu Xia, Yue Zhang, Hui Hu

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Expression of porcine interferon-α and its bioactivity analysis in vitro and in vivo

Pengtao Wang, Lu Xia, Xiuli Liang, Fangfang Han et autres

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Rhodanine derivative LJ001 inhibits TGEV and PDCoV replication in vitro

Yunfei Zhang, Lu Xia, Yixin Yuan, Qianqian Li et autres

Transmissible gastroenteritis virus (TGEV) and porcine deltacoronavirus (PDCoV) are members of the family coronaviridae and mainly cause acute diarrhea/vomiting, dehydration and mortality in piglets, which lead to huge economic losses to the swine industry. Rhodanine derivative LJ001 has been verified to be …

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Assessment of hemagglutination activity of porcine deltacoronavirus

Yunfei Zhang, Han Li, Lu Xia, Yixin Yuan et autres

(PDCoV) is an emerging swine enteric coronavirus that causes diarrhea in piglets. However, the biological characteristics of PDCoV are unclear. In this study, the hemagglutination (HA) abilities of two PDCoV strains (CH-01 and HNZK-04) were investigated. Our results showed that PDCoV has …

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