Shouye Ma

M1 macrophage-targeted glucose-functionalized nanoparticles for berberine delivery and inflammatory microenvironment remodeling in osteoarthritis therapy

Weibei Sheng, Lian Li, Jin Zhao, Shouye Ma et autres

The inflammatory microenvironment mediated by synovial macrophages, particularly the pro-inflammatory M1 subtype, plays a central role in OA progression and represents a critical therapeutic target. However, delivery strategies that enable efficient and selective targeting of M1 macrophages for modulating the inflammatory microenvironment …

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Activation of the circAGFG1/miR-195-5p/PD-L1 axis induces lung injury in sepsis

Yang Bi, Rui Ding, Xinyan Liu, Yun He et autres

Severe sepsis can escalate to acute lung injury (ALI), a critical condition with limited treatment options. Emerging research highlights the role of non-coding RNAs, including microRNAs (miRNAs) and circular RNAs (circRNAs), in regulating epithelial and immune cell responses in sepsis-induced ALI. This …

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Design, synthesis, and in-vitro/in-vivo pharmacodynamic studies of novel aza-fused heterocyclic compounds against herpes simplex virus type 1

Wenhua Xue, Ying Qu, Shouye Ma, Zibo Li et autres

cn, nz (code pays fourni par la source)

Synthesis and pharmacodynamic evaluation of Dihydropteridone derivatives against PDCoV in vivo and in vitro

Kai Sun, Zhongmou Zhang, Jiani Xing, Shouye Ma et autres

nz, cn (code pays fourni par la source)

Modulation of the oxidative stress and nuclear factor kappaB activation by theaflavin 3,3'-gallate in the rats exposed to cerebral ischemia-reperfusion.

Fei Cai, C Li, Jiliang Wu, Qing Min et autres

The major pathobiological mechanisms of IR injury include excitotoxicity, oxidative stress, and inflammation. TF3, a major constituent of black tea, possesses biological functions such as anti-oxidative and anti-inflammatory activities. The purpose of this study was to verify the neuronal protective potential of …

cn (code pays fourni par la source)