Alan James Davidson

Morula complementation restores fetal kidneys in xenocompatible SALL1 null sheep

Sarah Jane Appleby, LM Fermin, Stephanie Delaney, Jingwei Wei et autres

Abstract To meet the global shortage of organs, extensive genome modifications have been performed to “humanize” livestock tissues for xenotransplantation. However, residual immune rejection remains a problem, prompting alternative approaches that explore the use of animals as hosts for growing human organs. …

nz (code pays fourni par la source)

A Biomimetic Micro‐Nano System Maximizing ‘Active Transport and Retention’ Effect in Solid Tumors

Kaiyun Yang, Jiajia Su, Alan James Davidson, Zimei Wu et autres

ABSTRACT The Active Transport and Retention (ATR) principle offers a new strategy to enhance tumor entry of nanodrugs via transcytosis. However, its application is limited by poor tumor‐homing, endothelial polarized efflux, and uncontrollable transcytosis of the nanodrug. Herein, we construct a bio‐mimetic …

nz, cn (code pays fourni par la source)

Introducing CLipPA lipid chemodiversity to enzymatically truncated polymyxin B: a soft drug strategy to combat Gram-negative pathogens

Tae‐Ung Na, Yann O. Hermant, Andrew Siow, Jeremy G. Owen et autres

A chemodiverse library of new semi-synthetic antimicrobial peptides is reported herein. The polymyxin B nonapeptide (PMBN) holds promise as a developmental platform to access potent antimicrobial lipopeptide derivatives that circumvent the serious side effects of natural polymyxins used in clinical settings. By …

nz (code pays fourni par la source)

Design, synthesis and biological activity of potential retrometabolic polymyxins via thiol–ene chemistry

Catherine J. Smith, Andrew Siow, Renata Kowalczyk, Scott Ferguson et autres

pre-established vinyl ester formation, permitting a novel intermolecular thiol-ene reaction with a cysteine thiol to form the polymyxin ring. This moiety aims to sensitise the analogue towards esterase enzymes concentrated within the proximal tubule cells of the kidneys, theoretically limiting polymyxin accumulation, …

nz (code pays fourni par la source)

Evaluating the current neuro-oncology capacity in Sub-Saharan Africa: A questionnaire-based survey

Francis Zerd, Lateef A Odukoya, Beverly Cheserem, Kwadwo Darko et autres

Background: Central nervous system (CNS) tumors are a significant cause of morbidity and mortality in Sub-Saharan Africa (SSA). This project aimed to assess and map out the current neuro-oncology capacity in SSA, brain tumor registries, and biobanks. Methods: This cross-sectional study utilized …

us, Kenya, Ghana, Côte d’Ivoire, gb, Nigéria, Rwanda, Tanzanie, Ouganda, Éthiopie, République démocratique du Congo, Bénin, ca, Afrique du Sud (code pays fourni par la source)

Somites are a source of nephron progenitors in zebrafish

Lori L. O’Brien, Alan James Davidson, Hao-Han Chang, Thitinee Vanichapol et autres

us (code pays fourni par la source)

Somites are a source of nephron progenitors in zebrafish

Zhenzhen Peng, Thitinee Vanichapol, Phong D. Nguyen, Hao-Han Chang et autres

For over a century it has been believed that the vertebrate kidney arises exclusively from the intermediate mesoderm. Here, we overturn this paradigm by demonstrating that some nephrons, the functional units of the kidney, originate from the somites- blocks of paraxial mesoderm …

nz, fr, au, ca, us (code pays fourni par la source)

Paediatric haematology/oncology workforce and training programmes for Africa: a regional analysis

Diriba Fufa, Asmaa Attia, Nihad Salifu, Kershinee Reddy et autres

Graduate medical education programmes in paediatric haematology/oncology (PHO) are necessary to train specialists to provide high-quality care for children and adolescents with cancer and haematologic diseases. In this study, we used the Education Program Assessment Tool (EPAT). The study consisted of three …

Éthiopie, Égypte, Mozambique, in, Tanzanie, Afrique du Sud, nl, br, Ouganda, Kenya, Ghana, us, Maroc, be (code pays fourni par la source)

Somites are a source of nephron progenitors in zebrafish

Zhenzhen Peng, Thitinee Vanichapol, Phong D. Nguyen, Hao-Han Chang et autres

Summary For over a century it has been believed that the vertebrate kidney arises exclusively from the intermediate mesoderm. Here, we overturn this paradigm by demonstrating that some nephrons, the functional units of the kidney, originate from the somites--blocks of paraxial mesoderm …

nz, fr, au, ca, us (code pays fourni par la source)

High efficiency organoid-derived cyst cultures as a drug discovery platform for polycystic kidney disease

Thitinee Vanichapol, Ruby Wangford, Misao Takemoto, Motonari Uesugi et autres

ABSTRACT Autosomal dominant polycystic kidney disease (ADPKD) causes the slow, progressive formation of fluid-filled cysts within the kidney that ultimately leads to renal failure. Despite being the most common genetic kidney disease, the range of therapies for ADPKD is limited. Ureteric bud …

nz, jp (code pays fourni par la source)

Permanent defects in renal medullary structure and function after reversal of urinary obstruction

Thitinee Vanichapol, Alex Gonzalez, Rachel Delgado, Maya Brewer et autres

Urinary obstruction causes injury to the renal medulla, impairing the ability to concentrate urine and increasing the risk of progressive kidney disease. However, the regenerative capacity of the renal medulla after reversal of obstruction is poorly understood. To investigate this, we developed …

nz, us (code pays fourni par la source)

Resazurin dye is an in vivo sensor of kidney tubular function

Shirely M. Acosta Martinez, Isaac Z. Karel, Josie A. Silvaroli, Eman Ahmed et autres

us, nz, jp (code pays fourni par la source)