Shira Cohen

Efficacy and safety of autologous whole blood clot in diabetic foot ulcers: a randomised controlled trial

Robert Snyder, Aksone Nouvong, Jesus G. Ulloa, Naz Wahab et autres

OBJECTIVE: Diabetic foot ulcers (DFUs) present a significant global health challenge, resulting in high morbidity and economic costs. Current available treatments often fail to achieve satisfactory healing rates, highlighting the need for novel therapies. This study evaluated the safety and efficacy of …

us, Afrique du Sud (code pays fourni par la source)

α-Synuclein acts as a cholesteryl-ester sensor on lipid droplets regulating organelle size and abundance

Reeba Susan Jacob, Alessandro Dema, Hélène Chérot, Calvin Dumesnil et autres

Abstract While aggregated alpha-Synuclein (αSyn) is commonly associated with Parkinson’s disease, its physiological function as a membrane-binding protein is poorly understood. Here, we show that endogenous αSyn binds lipid droplets (LDs) in multiple human cell lines and in stem cell-derived dopaminergic neurons. …

il, de, fr, at, ca (code pays fourni par la source)

A3 adenosine receptor allosteric modulator CF602 reverses erectile dysfunction in a diabetic rat model

Inbal Itzhak, Shira Cohen, Sari Fishman, Pnina Fishman

Adenosine plays a major role in erection by binding to its receptors and activating pathways resulting in increased arterial blood flow and intracavernosal pressure (ICP). CF602, an allosteric modulator of the A3 adenosine receptor (A3AR), increases the binding affinity of the endogenous …

il (code pays fourni par la source)

Host transcriptional signatures as predictive markers of infection in children

Asunción Mejías, Shira Cohen, Rebecca M Glowinski, Octavio Ramilo

PURPOSE OF REVIEW: Analyses of the host transcriptional response to infection has proved to be an alternative diagnostic strategy to standard direct pathogen detection. This review summarizes the value of applying blood and mucosal transcriptome analyses for the diagnosis and management of …

us (code pays fourni par la source)

Engineering Stem Cell Factor Ligands with Different c-Kit Agonistic Potencies

Tal Tilayov, Tal Hingaly, Yariv Greenshpan, Shira Cohen et autres

Receptor tyrosine kinases (RTKs) are major players in signal transduction, regulating cellular activities in both normal regeneration and malignancy. Thus, many RTKs, c-Kit among them, play key roles in the function of both normal and neoplastic cells, and as such constitute attractive …

il (code pays fourni par la source)

Nanobodies Targeting Prostate-Specific Membrane Antigen for the Imaging and Therapy of Prostate Cancer

Lior Rosenfeld, Amiram Sananes, Yuval Zur, Shira Cohen et autres

Abstract The repertoire of methods for the detection and chemotherapeutic treatment of prostate cancer (PCa) is currently limited. Prostate-specific membrane antigen (PSMA) is overexpressed in PCa tumors and can be exploited for both imaging and drug delivery. We developed and characterized four …

il (code pays fourni par la source)

Oxidation and passivation of U(AlxSi1-x)3 alloy at elevated temperatures

Shira Cohen, Maayan Matmor, M. Vaknin, Gennady Rafailov et autres

il (code pays fourni par la source)

DNA Sequence Recognition by DNA Primase Using High-Throughput Primase Profiling

Stefan Ilić, Shira Cohen, Ariel Afek, Raluca Gordân et autres

DNA primase synthesizes short RNA primers that initiate DNA synthesis of Okazaki fragments on the lagging strand by DNA polymerase during DNA replication. The binding of prokaryotic DnaG-like primases to DNA occurs at a specific trinucleotide recognition sequence. It is a pivotal …

il, us, it (code pays fourni par la source)

DNA Sequence Recognition by DNA Primase Using High-Throughput Primase Profiling

Stefan Ilić, Shira Cohen, Ariel Afek, Raluca Gordân et autres

DNA primase synthesizes short RNA primers that initiate DNA synthesis of Okazaki fragments on the lagging strand by DNA polymerase during DNA replication. The binding of prokaryotic DnaG-like primases to DNA occurs at a specific trinucleotide recognition sequence. It is a pivotal …

il, us, it (code pays fourni par la source)

The A3 adenosine receptor agonist, namodenoson, ameliorates non‑alcoholic steatohepatitis in mice

Pnina Fishman, Shira Cohen, Inbal Itzhak, Johnny Amer et autres

The Wnt/β‑catenin pathway confers a chain of molecular events in livers affected by non‑alcoholic steatohepatitis (NASH). Namodenoson, a selective agonist of the A3 adenosine receptor (A3AR), which is highly expressed in pathological liver cells, induces a robust anti‑inflammatory effect in the liver, …

il (code pays fourni par la source)

Specific and label-free immunosensing of protein-protein interactions with silicon-based immunoFETs

Ie Mei Bhattacharyya, Shira Cohen, Awad Shalabny, Muhammad Y. Bashouti et autres

il (code pays fourni par la source)

Targeting the A3 adenosine receptor to treat cytokine release syndrome in cancer immunotherapy

Shira Cohen, Pnina Fishman

Abstract: Cancer patients undergoing immunotherapy may develop cytokine release syndrome (CRS), an inflammatory cytokine storm condition, followed by neurotoxic manifestations and may be life-threatening. The current treatments for CRS successfully reduce the inflammatory response but may limit the anticancer effect of the …

il (code pays fourni par la source)