Karen Coste

RAGE phosphorylation by CK2 in human epithelial cell model: Modulation of connexin 43 expression

Karen Coste, Anne-Marie Hesse, Geoffroy Marceau, Odile Filhol et autres

The receptor for advanced glycation end products (RAGE) is a membrane protein involved in many diseases linked to epithelial dysfunction. Its activation mechanism remains unclear because RAGE lacks intrinsic kinase activity depending on other kinases for phosphorylation. Using an epithelial amniotic cell …

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Activation of the RAGE pathway following phosphorylation by CK2 in an amniotic epithelial model.

Karen Coste, Anne-Marie Hesse, Geoffroy Marceau, Odile Filhol et autres

fr (code pays fourni par la source)

Necrotizing Enterocolitis in the newborn: a metabolic disturbance revealed by fecal volatolomics useful for diagnosis eight days before first symptoms

Jérémy Ratel, Ugo Troin, Nathalie Kondjoyan, Frédéric Mercier et autres

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Early-onset neonatal sepsis: Effectiveness of classification based on ante- and intrapartum risk factors and clinical monitoring

Laurie Dalut, Anne Brunhes, Sébastien Cambier, Denis Gallot et autres

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Characterization of RAGE and CK2 Expressions in Human Fetal Membranes

Karen Coste, Shaam Bruet, Caroline Chollat-Namy, Odile Filhol et autres

At the feto-maternal interface, fetal membranes (FM) play a crucial role throughout pregnancy. FM rupture at term implicates different sterile inflammation mechanisms including pathways activated by the transmembrane glycoprotein receptor for advanced glycation end-products (RAGE) belonging to the immunoglobulin superfamily. As the …

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Neonatal outcomes for women at risk of preterm delivery given half dose versus full dose of antenatal betamethasone: a randomised, multicentre, double-blind, placebo-controlled, non-inferiority trial

Thomas Schmitz, Muriel Doret-Dion, Loı̈c Sentilhes, Olivier Parant et autres

fr, ch (code pays fourni par la source)

Soluble Receptor of Advanced Glycation End-Products (sRAGE) in Pediatric Asthma: A Prospective Study in 68 Children Aged 7 Years

Julie Magnier, Valérie Julian, Vincent Sapin, Aurélien Mulliez et autres

Background: Asthma is a chronic inflammatory disease of the airways common in children. Soluble advanced glycation end-product receptor (sRAGE) is a blood biomarker of lung damage and inflammation. We sought to determine whether it could also be a biomarker in childhood asthma. …

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AIM in Neonatal and Pediatric Intensive Care

David Forsberg, Antoine Honoré, Kerstin Jost, Emma Persad et autres

se, at, fr (code pays fourni par la source)

Tocolysis in the management of preterm prelabor rupture of membranes at 22–33 weeks of gestation: study protocol for a multicenter, double-blind, randomized controlled trial comparing nifedipine with placebo (TOCOPROM)

Elsa Lorthe, Gilles Kayem, Pierre‐Yves Ancel, Hendy Abdoul et autres

BACKGROUND: Preterm prelabor rupture of membranes (PPROM) before 34 weeks of gestation complicates 1% of pregnancies and accounts for one-third of preterm births. International guidelines recommend expectant management, along with antenatal steroids before 34 weeks and antibiotics. Up-to-date evidence about the risks …

fr, ch (code pays fourni par la source)

Pathophysiological Implication of Pattern Recognition Receptors in Fetal Membranes Rupture: RAGE and NLRP Inflammasome

Hélèna Choltus, Marilyne Lavergne, Coraline De Sousa Do Outeiro, Karen Coste et autres

Preterm prelabor ruptures of fetal membranes (pPROM) are a pregnancy complication responsible for 30% of all preterm births. This pathology currently appears more as a consequence of early and uncontrolled process runaway activation, which is usually implicated in the physiologic rupture at …

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Neonatal sepsis prediction through clinical decision support algorithms: A systematic review

Emma Persad, Kerstin Jost, Antoine Honoré, David Forsberg et autres

AIM: To systematically summarise the current evidence of employing clinical decision support algorithms (CDSAs) using non-invasive parameters for sepsis prediction in neonates. METHODS: A comprehensive search in PubMed, CENTRAL and EMBASE was conducted. Screening, data extraction and risk of bias were performed …

at, se, fr (code pays fourni par la source)

Blood biomarkers of early diagnosis for neonatal bacterial infections: back from Senegal cohort

Najah Fatou Gueye Coly, Julie Durif, Idrissa Bass, Souleymane Thiam et autres

technology, PCT by chemiluminescence, orosomucoid by immunoturbidimetry and SAA by ELISA technique. 20 newborns had probable infection and six established infection. Deaths and complications were significantly greater in these groups. With an optimal decision threshold of 16.3 mg/L, CRP performed better (compared …

Sénégal, fr (code pays fourni par la source)