Jianmin Yin

Hedgehog-driven adaxial cell constriction patterns slow muscle fate and somite boundary remodeling in the presomitic mesoderm

Ying Wang, X X Li, Rui Xia, Yinan Wan et autres

How morphogen signaling interfaces with cell behaviors and mechanics to coordinate body axis patterning has remained largely unclear. Here, we uncover a mechanochemical program that directs slow muscle fate commitment and somite boundary remodeling in the presomitic mesoderm (PSM). Hedgehog, secreted from …

cn, ch, sg (code pays fourni par la source)

Junctional and Actomyosin Dynamics Drive Endothelial Cell Rearrangements during Vascular Tube Formation

Ludovico Maggi, Jianmin Yin, Cora Wiesner, Ilkka Paatero et autres

Lumen formation is a key process during the morphogenesis of tubular organs such as the vertebrate vascular network. At the cellular level, lumen formation can be achieved by cell shape changes or cell rearrangements. We have previously shown that such cell rearrangements …

ch, fi, de (code pays fourni par la source)

Junctional and Actomyosin Dynamics Drive Endothelial Cell Rearrangements during Vascular Tube Formation

Ludovico Maggi, Jianmin Yin, Ilkka Paatero, Cora Wiesner et autres

Lumen formation is a key process during the morphogenesis of tubular organs such as the vertebrate vascular network. At the cellular level, lumen formation can be achieved by cell shape changes or cell rearrangements. We have previously shown that such cell rearrangements …

ch, fi, de (code pays fourni par la source)

Junctional and Actomyosin Dynamics Drive Endothelial Cell Rearrangements during Vascular Tube Formation

Heinz‐Georg Belting, Ludovico Maggi, Jianmin Yin, Ilkka Paatero et autres

ch, fi, de (code pays fourni par la source)

Initiation of lumen formation from junctions via differential actomyosin contractility regulated by dynamic recruitment of Rasip1

Jianmin Yin, Niels Schellinx, Ludovico Maggi, Kathrin Gundel et autres

De novo lumen formation necessitates the precise segregation of junctional proteins from apical surfaces, yet the underlying mechanisms remain unclear. Using a zebrafish model, we develop a series of molecular reporters, photo-convertible and optogenetic tools to study the establishment of apical domains. …

ch, de, jp (code pays fourni par la source)

Oscillatory contractile forces refine endothelial cell-cell interactions for continuous lumen formation governed by Heg1/Ccm1

Jianmin Yin, Ludovico Maggi, Cora Wiesner, Markus Affolter et autres

The formation and organization of complex blood vessel networks rely on various biophysical forces, yet the mechanisms governing endothelial cell-cell interactions under different mechanical inputs are not well understood. Using the dorsal longitudinal anastomotic vessel (DLAV) in zebrafish as a model, we …

ch (code pays fourni par la source)

Initiation of Lumen Formation from Junctions via Differential Actomyosin Contractility Regulated by Dynamic Recruitment of Rasip1

Jianmin Yin, Niels Schellinx, Ludovico Maggi, Kathrin Gundel et autres

Abstract Vascular lumens are essential for the dispersal of nutrients, oxygen, and immune cells throughout the body. De novo lumen formation necessitates the precise segregation of junctional proteins from apical surfaces. Direct visualization of this process and a comprehensive understanding on how …

ch, de, jp (code pays fourni par la source)

Vinculin controls endothelial cell junction dynamics during vascular lumen formation

Maria Paraskevi Kotini, Miesje M. van der Stoel, Jianmin Yin, Mitchell K. L. Han et autres

Blood vessel morphogenesis is driven by coordinated endothelial cell behaviors. Active remodeling of cell-cell junctions promotes cellular plasticity while preserving vascular integrity. Here, we analyze the dynamics of endothelial adherens junctions during lumen formation in angiogenic sprouts in vivo. Live imaging in …

ch, nl, de (code pays fourni par la source)

LY235959 attenuates development phase of Methamphetamine-Induced behavioral sensitization through the PP2A/B - AKT cascade in the dorsal striatum of C57/BL6 mice

Gang Chen, Canyu Yang, Min Liang, Jianmin Yin et autres

cn (code pays fourni par la source)

MicroRNA-31-3p/RhoA signaling in the dorsal hippocampus modulates methamphetamine-induced conditioned place preference in mice

Hongyan Qian, Qing Shang, Min Liang, Baoyao Gao et autres

cn (code pays fourni par la source)

Control of dynamic cell behaviors during angiogenesis and anastomosis by Rasip1

Minkyoung Lee, Charles Betz, Jianmin Yin, Ilkka Paatero et autres

Organ morphogenesis is driven by a wealth of tightly orchestrated cellular behaviors, which ensure proper organ assembly and function. Many of these cell activities involve cell-cell interactions and remodeling of the F-actin cytoskeleton. Here, we analyze the requirement for Rasip1 (Ras-interacting protein …

ch (code pays fourni par la source)

Building the complex architectures of vascular networks: Where to branch, where to connect and where to remodel?

Jianmin Yin, Daniel Heutschi, Heinz‐Georg Belting, Markus Affolter

ch (code pays fourni par la source)