Weifeng Xu

αO-Conotoxin GeXIVA[1,2] Attenuates Paclitaxel-Induced Neurotoxicity by Suppressing Ferroptosis via the Nrf2/SLC7A11/GSH/GPX4 Pathway

Dongmeng Liu, Jiaqi Yu, Weifeng Xu, Yihong Shen et autres

Chemotherapy-induced neurotoxicity, affecting both the central and peripheral nervous systems, is a frequent and severe adverse effect of paclitaxel (PAC) treatment with limited therapeutic options. We previously demonstrated that PAC triggers neuronal cell death via ferroptosis. αO-Conotoxin GeXIVA[1,2], a marine-derived peptide, has …

cn, mo (code pays fourni par la source)

Distinct transmission sites within a synapse for strengthening and homeostasis

Yang Yue, Man Ho Wong, Xiaojie Huang, Delia N. Chiu et autres

At synapses, miniature synaptic transmission forms the basic unit of evoked transmission, thought to use one canonical transmission site. Two general types of synaptic plasticity, associative plasticity to change synaptic weights and homeostatic plasticity to maintain an excitatory balance, are so far …

us, de (code pays fourni par la source)

α-Conotoxin TxIB Reversed Nicotine-Induced Locomotor Sensitization and Nicotine-Enhanced Dopaminergic Activity in Mice

Weifeng Xu, Meiting Wang, Xiaodan Li, Rongyan He et autres

Nicotine addiction is a serious global public health problem, so there is an urgent necessity to develop novel effective smoking cessation treatments with fewer adverse effects. Spontaneous behavioral sensitization induced by repeated intermittent exposure to the addictive substance represents a classical animal …

cn (code pays fourni par la source)

A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity

Wen Wang, Meiting Wang, Huanbai Wang, Weifeng Xu et autres

Background and Purpose Nicotinic acetylcholine receptors (nAChRs), which are expressed throughout the mammalian brain, mediate a variety of physiological functions. Despite their widespread presence, the functions of nAChRs are not yet fully understood. α-Conotoxins, which are peptides derived from the venom of …

cn (code pays fourni par la source)

Enhancement of synaptic AMPA receptors depends mutually on Src and PSD-95

Xiaojie Huang, Juliane M. Krüger, Anna Beroun, Weifeng Xu et autres

Abstract Synaptic incorporation and removal of AMPA receptors is highly regulated to modulate the strength of synaptic transmission for long-term synaptic plasticity during brain development and associative learning. PSD-93α2 and PSD-95α, two paralogs of the DLG-MAGUK protein family of signaling scaffolds govern …

us, de, pl (code pays fourni par la source)

Neurogranin, Encoded by the Schizophrenia Risk Gene NRGN, Bidirectionally Modulates Synaptic Plasticity via Calmodulin-Dependent Regulation of the Neuronal Phosphoproteome

Hongik Hwang, Matthew J. Szucs, Lei J. Ding, Andrew S. Allen et autres

kr, us (code pays fourni par la source)

Silent Synapse-Based Mechanisms of Critical Period Plasticity

Weifeng Xu, Siegrid Löwel, Oliver M. Schlüter

that govern the experience-dependent refinement process. Nascent gestalt synapses are constantly formed as AMPA receptor-silent synapses which are the substrates for critical period plasticity. Experience drives the unsilencing and stabilization of gestalt synapses, as well as synapse pruning. This maturation process changes …

us, de (code pays fourni par la source)

Comparison of Statistical Tests and Power Analysis for Phosphoproteomics Data

Lei J. Ding, Hannah M. Schlüter, Matthew J. Szucs, Rushdy Ahmad et autres

Advances in protein tagging and mass spectrometry have enabled generation of large quantitative proteome and phosphoproteome data sets, for identifying differentially expressed targets in case–control studies. The power study of statistical tests is critical for designing strategies for effective target identification and …

us, gb (code pays fourni par la source)

NEXMIF/KIDLIA Knock-out Mouse Demonstrates Autism-Like Behaviors, Memory Deficits, and Impairments in Synapse Formation and Function

James P. Gilbert, Margaret G. O’Connor, Sebastian Templet, Mahsa Moghaddam et autres

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disability that demonstrates impaired social interactions, communication deficits, and restrictive and repetitive behaviors. ASD has a strong genetic basis and many ASD-associated genes have been discovered thus far. Our previous work has shown that …

us, cn (code pays fourni par la source)

A schizophrenia risk gene, NRGN , bidirectionally modulates synaptic plasticity via regulating the neuronal phosphoproteome

Hongik Hwang, Matthew J. Szucs, Lei J. Ding, Andrew S. Allen et autres

Abstract NRGN is a schizophrenia risk gene identified in recent genetic studies, encoding a small neuronal protein, neurogranin (Ng). Individuals carrying a risk variant of NRGN showed decreased hippocampal activation during contextual fear conditioning. Furthermore, the expression of Ng was reduced in …

us (code pays fourni par la source)

Quantitative synapse analysis for cell-type specific connectomics

Dika A. Kuljis, Khaled Zemoura, Cheryl A. Telmer, Jiseok Lee et autres

Abstract Anatomical methods for determining cell-type specific connectivity are essential to inspire and constrain our understanding of neural circuit function. We developed new genetically-encoded reagents for fluorescence-synapse labeling and connectivity analysis in brain tissue, using a fluorogen-activating protein (FAP)-or YFP-coupled, postsynaptically-localized neuroligin-1 …

us (code pays fourni par la source)

SAP102 regulates synaptic AMPAR function through a CNIH-2-dependent mechanism

Mingna Liu, Rebecca Shi, Hongik Hwang, Kyung Seok Han et autres

The postsynaptic density (PSD)-95-like, disk-large (DLG) membrane-associated guanylate kinase (PSD/DLG-MAGUK) family of proteins scaffold α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) complexes to the postsynaptic compartment and are postulated to orchestrate activity-dependent modulation of synaptic AMPAR functions. SAP102 is a key member of this family, …

us (code pays fourni par la source)