Profil bibliographique

Xiao Zhang

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

2Publications signalées
66Citations signalées
5Affiliations récentes

Les institutions déclarées

Chinese Academy of SciencesGuangzhou Institutes of Biomedicine and HealthGuangzhou Regenerative Medicine and Health Guangdong LaboratoryUniversity of Chinese Academy of SciencesUniversity of Hong Kong

Les domaines associés

RNA modifications and cancerDNA Repair MechanismsRNA and protein synthesis mechanismsRNA Research and SplicingCancer-related gene regulation

Les publications récentes

Accès ouvert 2024 article OpenAlex

Perturbation of METTL1-mediated tRNA N7- methylguanosine modification induces senescence and aging

Yudong Fu, Fan Jiang, Xiao Zhang, Yingyi Pan et autres

Cellular senescence is characterized by a decrease in protein synthesis, although the underlying processes are mostly unclear. Chemical modifications to transfer RNAs (tRNAs) frequently influence tRNA activity, which is crucial for translation. We describe how tRNA N7-methylguanosine (m7G46) methylation, catalyzed by METTL1-WDR4, …

cn, hk, fr (code pays fourni par la source)

39 citations Nature Communications
Accès ouvert 2023 article OpenAlex

Therapeutic targeting of CPSF3-dependent transcriptional termination in ovarian cancer

Peiye Shen, Kaiyan Ye, Huaijiang Xiang, Zhenfeng Zhang et autres

Transcriptional dysregulation is a recurring pathogenic hallmark and an emerging therapeutic vulnerability in ovarian cancer. Here, we demonstrated that ovarian cancer exhibited a unique dependency on the regulatory machinery of transcriptional termination, particularly, cleavage and polyadenylation specificity factor (CPSF) complex. Genetic abrogation …

cn, hk (code pays fourni par la source)

27 citations Science Advances
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