Ivanova Mv

Intraventricular Administration of Exosomes from Patients with Amyotrophic Lateral Sclerosis Provokes Motor Neuron Disease in Mice

A. V. Stavrovskaya, Д. Н. Воронков, Anastasiia K. Pavlova, A. S. Olshanskiy et autres

Amyotrophic lateral sclerosis (ALS) is a severe disease of the central nervous system (CNS) characterized by motor neuron damage leading to death from respiratory failure. The neurodegenerative process in ALS is characterized by an accumulation of aberrant proteins (TDP-43, SOD1, etc.) in …

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High heterogeneity of cross-reactive immunoglobulins in multiple sclerosis presumes combining of B-cell epitopes for diagnostics: a case-control study

Leyla A. Ovchinnikova, Igor E. Eliseev, Samir S. Dzhelad, Taras O. Simaniv et autres

Background: Multiple sclerosis (MS) is a neuroinflammatory disease triggered by a combination of genetic traits and external factors. Autoimmune nature of MS is proven by the identification of pathogenic T cells, but the role of autoantibody-producing B cells is less clear. A …

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Multiple Sclerosis Is Associated with Immunoglobulin Germline Gene Variation of Transitional B Cells

Yakov A. Lomakin, Leyla A. Ovchinnikova, M. N. Zakharova, Ivanova Mv et autres

The regulatory functions of the B-cell compartment play an important role in the development and suppression of the immune response. Disruption of their anti-inflammatory functions may lead to the acceleration of immunopathological processes, and to autoimmune diseases, in particular. Unfortunately, the exact …

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The neuroscience of language and aphasia.

Nina F. Dronkers, Ivanova Mv

Deconvolution of B cell receptor repertoire in multiple sclerosis patients revealed a delay in tBreg maturation

Yakov A. Lomakin, Ivan V. Zvyagin, Leyla A. Ovchinnikova, Marsel Rasimovich Kabilov et autres

Background B lymphocytes play a pivotal regulatory role in the development of the immune response. It was previously shown that deficiency in B regulatory cells (Bregs) or a decrease in their anti-inflammatory activity can lead to immunological dysfunctions. However, the exact mechanisms …

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Abstract PO-074: Identification of C-MET receptor as a therapeutic target in patient-specific tumoroid models of metastatic pancreatic adenocarcinoma allows identification of a new mode of action for its inhibitors

Liam Deems, Ivanova Mv, Cheryl E. Murphy, Amit Shahar et autres

Abstract Creating patient-specific models with a high level of characterization and functionality in tumoroid modeling enables a better understanding of the disease drivers in metastatic cancers. It presents the opportunity for personalized treatment with novel therapeutic reagents in underrepresented cancers such as …

Different neuroinflammatory gene expression profiles in highly active and benign multiple sclerosis

Ivanova Mv, Anastasiya S. Voronkova, Vladimir S. Sukhorukov, Maria N. Zakharova

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Erratum to: Variability of the Expression Patterns of Neuroinflammatory Genes in Mononuclear Cells of Peripheral Blood in Amyotrophic Lateral Sclerosis

Ivanova Mv, Anastasiya S. Voronkova, Vladimir S. Sukhorukov, Mariya N. Zakharova

An Erratum to this paper has been published: https://doi.org/10.1134/S1819712421340018

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Variability of the Expression Patterns of Neuroinflammatory Genes in Mononuclear Cells of Peripheral Blood in Amyotrophic Lateral Sclerosis

Ivanova Mv, Anastasiya S. Voronkova, Vladimir S. Sukhorukov, Mariya N. Zakharova

Abstract —Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with steadily progressing death of motor neurons in the brain and spinal cord. The disease is incurable and results in the patient’s death within 3–5 years on average. The mechanisms of initiation, progression, …

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Exosomal Angiogenin as a Potential Biomarker in Amyotrophic Lateral Sclerosis

Ivanova Mv, Е. О. Чеканова, Boris V. Belugin, Inna V. Dolzhikova et autres

Abstract—Exosomes are extracellular vesicles that represent an important mode of intercellular communication. It is thought that exosomes can carry biologically active molecules associated with the progressive spreading of amyotrophic lateral sclerosis (ALS). ALS is a fatal neurodegenerative disease characterized by the progressive …

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Differential Diagnostics of Active Progressing Multiple Sclerosis Using a Fluorescent Biomarker with Resonance Energy Transfer

Yakov A. Lomakin, A. A. Kudryaeva, Nikita N. Kostin, Stanislav S. Terekhov et autres

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Exosomal Transport and Progression of Neurodegeneration in Amyotrophic Lateral Sclerosis

Ivanova Mv, Е. О. Чеканова, Boris V. Belugin, Irina L. Tutykhina et autres

Abstract In recent years, increasing attention has been paid to the study of the communication between cells in the nervous system with extracellular vesicles, including exosomes, under physiological and pathological conditions. Exosomes are small extracellular vesicles ranging in size from 50 to …

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