Luis Angel Rioja Sanz

Predicting Sex in White Rhinoceroses: A Statistical Model for Conservation Management

Leticia Concepción Velasco Martínez, Paloma Jimena de Andrés, José Manuel Caperos Montalbán, Gema Silván et autres

Ensuring the effective management of every rhinoceros population is crucial for securing a future for the species, especially considering the escalating global threat of poaching and the challenges faced in captive breeding programs for this endangered species. Steroid hormones play pivotal roles …

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Accurate prediction of birth implementing a statistical model through the determination of steroid hormones in saliva

Silvia Arranz Alonso, Sara Cáceres, Daniel Vélez, Luis Angel Rioja Sanz et autres

Steroidal hormone interaction in pregnancy is crucial for adequate fetal evolution and preparation for childbirth and extrauterine life. Estrone sulphate, estriol, progesterone and cortisol play important roles in the initiation of labour mechanism at the start of contractions and cervical effacement. However, …

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Longitudinal study on steroid hormone variations during the second trimester of gestation: a useful tool to confirm adequate foetal development

Silvia Arranz Alonso, Sara Cáceres, Daniel Vélez, Luis Angel Rioja Sanz et autres

Abstract Background The interaction of hormonal factors are crucial for good foetal development. During the second trimester of gestation, most of the main physiological processes of foetal development occur. Therefore, the aim of this study was to determine the variations in the …

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Using Copula to Model Dependence When Testing Multiple Hypotheses in DNA Microarray Experiments: A Bayesian Approximation

Elisa da Conceição José Maria, Isabel Salazar, Luis Angel Rioja Sanz, Miguel Angel Gómez-Villegas

Many experiments require simultaneously testing many hypotheses. This is particularly relevant in the context of DNA microarray experiments, where it is common to analyze many genes to determine which of them are differentially expressed under two conditions. Another important problem in this …

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The Effects of the Toll-Like Receptor 4 Antagonist, Ibudilast, on Sevoflurane’s Minimum Alveolar Concentration and the Delayed Remifentanil-Induced Increase in the Minimum Alveolar Concentration in Rats

Pablo Delfino Pérez, Javier Benito, Gonzalo Polo-Paredes, Carlota Largó et autres

BACKGROUND: Ultralow doses of naloxone, an opioid and toll-like receptor 4 antagonist, blocked remifentanil-induced hyperalgesia and the associated increase in the minimum alveolar concentration (MAC), but not tolerance. The aim was to determine the effects of the toll-like receptor 4 antagonist, ibudilast, …

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Impacto de la contaminación por nitrógeno de aguas continentales: (Proyecto Life "Nitratos"

Alberto Lafarga Arnal, J. Del Valle de Lersundi, Luis Angel Rioja Sanz

A Bayesian decision procedure for testing multiple hypotheses in DNA microarray experiments

Miguel Angel Gómez-Villegas, Isabel Salazar, Luis Angel Rioja Sanz

DNA microarray experiments require the use of multiple hypothesis testing procedures because thousands of hypotheses are simultaneously tested. We deal with this problem from a Bayesian decision theory perspective. We propose a decision criterion based on an estimation of the number of …

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Modelos predictivos de recidiva bioquímica en el cáncer de próstata tras tratamiento local. Validez de los nomogramas

Ángel Borque‐Fernando, Luis Mariano Esteban, Gerardo Sanz Sáiz, Luis Angel Rioja Sanz

OBJETIVOS En la presente revision narrativa presentamos una actualizacion del concepto de nomograma en el contexto de los modelos predictivos en cancer de prostata. En realidad pretendemos dar respuesta desde un punto de vista practico y a la vez critico a las …

Bayesian Analysis of Multiple Hypothesis Testing with Applications to Microarray Experiments

M. Concepción Ausín, Miguel Angel Gómez-Villegas, Beatriz González‐Pérez, María Teresa Rodríguez Bernal et autres

Recently, the field of multiple hypothesis testing has experienced a great expansion, basically because of the new methods developed in the field of genomics. These new methods allow scientists to simultaneously process thousands of hypothesis tests. The frequentist approach to this problem …

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Cáncer de próstata. Tratamiento hormonal

J. Rioja Zuazu, Luis Angel Rioja Sanz

A Bayesian analysis for the multivariate point null testing problem

Miguel Angel Gómez-Villegas, Paloma Maı́n, Luis Angel Rioja Sanz

A Bayesian test for the point null testing problem in the multivariate case is developed. A procedure to get the mixed distribution using the prior density is suggested. For comparisons between the Bayesian and classical approaches, lower bounds on posterior probabilities of …

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Production of recombinant forms of the propeptide COOH -terminal and the saposin B -type domain of the propeptide NH 2-terminal of the precursor of pulmonary surfactant protein B

Ángeles Bañares-Hidalgo, Elisa J. Cabré, Félix Gil-Dones, A. Bolaños et autres

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