Alain Combes

Predictive factors of successful renal replacement therapy weaning

Khalil Chaïbi, Yanis Akrour, Guillaume Louis, Laurent Martin Lefevre et autres

INTRODUCTION: Renal replacement therapy (RRT) is a life-saving intervention in severe acute kidney injury (AKI). After a clinician-initiated discontinuation, the likelihood of sustained liberation remains uncertain. We aimed to identify predictors of successful RRT weaning and to develop a pragmatic bedside tool …

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Factors associated with adverse haemodynamic events during the STARRT-AKI trial: a post-hoc secondary analysis

Yvelynne P. Kelly, Bruno R. da Costa, William Beaubien-Souligny, Edward G. Clark et autres

INTRODUCTION: Haemodynamic adverse events related to renal replacement therapy are a complication of all RRT modalities used in the ICU, including intermittent haemodialysis (IHD), sustained low efficiency dialysis (SLED) and continuous renal replacement therapy (CRRT). At present it is unclear which risk …

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Levosimendan to Facilitate Weaning From ECMO in Patients With Severe Cardiogenic Shock

Alain Combes, Ouriel Saura, Nicolas Nesseler, Saïd Lebbah et autres

Importance: Levosimendan may facilitate weaning from venoarterial extracorporeal membrane oxygenation (VA-ECMO) and improve survival, but supporting evidence remains limited. Objective: To assess whether early administration of levosimendan reduces the time to successful VA-ECMO weaning in patients with severe but potentially reversible cardiogenic …

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Combined heart-liver transplantation and Acute Kidney Injury: Risk factors and outcomes from CARDHEPAT registry

A. Filipa Cordeiro, Pascal Lebray, R. Guillemain, Samy Meriem et autres

Combined heart-liver transplantation (CHLT) offers new possibilities for patients with no other treatment options, yet it remains a rare and complex procedure. Despite an increase in its utilisation in recent years, data remain scarce, and many aspects of the procedure are not …

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Epidemiology of pain, delirium, psychiatric disorders, discomfort and sedation-analgesia management in the intensive care unit: a one-day nationwide study

Florian Blanchard, Angelina Barage, Bélaïd Bouhemad, Camille Miard et autres

BACKGROUND: The administration of sedatives and analgesics in intensive care units (ICUs) has evolved significantly over the past 20 years, shifting from deep to light sedation strategies to minimize adverse effects. Despite this shift, substantial variability persists in sedation-analgesia practices. This study …

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Impact of body mass index on 90-day survival in patients in cardiogenic shock treated with V-A ECMO: A propensity weighted analysis

Quentin Moyon, Jules Stern, Marc Pineton de Chambrun, Guillaume Lebreton et autres

fr (code pays fourni par la source)

Cost-Utility Analysis of Accelerated and Standard Strategies for Renal Replacement Therapy Initiation

Jeff Round, İlke Akpinar, Charles Yan, Natasha Patel et autres

Importance: Little is known about the long-term costs and outcomes related to strategies for timing of initiation of kidney replacement therapy (KRT) in critically ill patients with severe acute kidney injury (AKI). Objective: To estimate the cost-utility and cost-effectiveness of accelerated KRT …

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Effect of ECMO Flow Variations on Pulmonary Capillary Wedge Pressure in Patients With Cardiogenic Shock

Ouriel Saura, Guillaume Hékimian, Grégoire Del Marmol, Manuela Lucenteforte et autres

fr (code pays fourni par la source)

Pharmacokinetic/Pharmacodynamic of ceftolozane/tazobactam in critically ill patients receiving extracorporeal membrane oxygenation (ECMO): a retrospective cohort analysis

Alexandre Coppens, Melchior Gautier, Noël Zahr, Helga Junot et autres

Ceftolozane/tazobactam (C/T), a β-lactam/β-lactamase inhibitor combination, demonstrates potent activ-

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Temporary circulatory support for cardiogenic shock

Grégoire Del Marmol, Quentin Moyon, Alain Combes

PURPOSE OF REVIEW: Temporary circulatory support (TCS) devices play a crucial role in stabilizing patients with refractory cardiogenic shock. They provide essential hemodynamic support and serve as a bridge to recovery, decision-making, heart transplantation, or long-term mechanical circulatory support. However, despite their …

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Prehospital antiplatelet therapy in patients with out-of-hospital cardiac arrest suspected of acute coronary syndrome

P Charleux, Juliette Chommeloux, Anthony Elhadad, Niki Procopi et autres

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Clinical validation of pulmonary artery catheter use for continuous thermodilution cardiac output monitoring in VA-ECMO patients

David Levy, Matthieu Schmidt, Guillaume Hékimian, Alain Combes et autres

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