Yukie Tashiro

A 25-year clonal resurrection in adult T-cell leukemia-lymphoma relapse

Atae Utsunomiya, Jun‐ichirou Yasunaga, Tomohisa Tabuchi, Nobuaki Nakano et autres

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Clinical significance of NOTCH1 and FBXW7 alterations in adult T-cell leukemia/lymphoma

Yuma Sakamoto, Takashi Ishida, Ayako Masaki, Takayuki Murase et autres

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Dupilumab aggravates Sézary syndrome: The importance of accurate pathological diagnosis

Y Homma, Kentaro Yonekura, Yukie Tashiro, Kenjiro Ninomiya et autres

We report a case of Sézary syndrome aggravated by dupilumab. Although a diagnosis of atopic dermatitis was made previously, our retrospective diagnosis was cutaneous T-cell lymphoma.

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Integrated genetic and clinical prognostic factors for aggressive adult T-cell leukemia/lymphoma

Takuro Kameda, Keisuke Kataoka, Ayako Kamiunten, Michihiro Hidaka et autres

The prognosis of aggressive adult T-cell leukemia/lymphoma (ATL) is poor, and allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment. In order to identify favorable prognostic patients after intensive chemotherapy, and who therefore might not require upfront allo-HSCT, we aimed to …

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CCR7 alterations associated with inferior outcome of adult T‐cell leukemia/lymphoma under mogamulizumab treatment

Yuma Sakamoto, Takashi Ishida, Ayako Masaki, Takayuki Murase et autres

Adult T-cell leukemia/lymphoma (ATL) patients have a very poor prognosis. The humanized anti-CCR4 therapeutic monoclonal antibody, mogamulizumab, is a key agent for ATL treatment. Our previous integrated molecular analysis demonstrated that among all the driver genes in ATL, CCR7 gene alterations were …

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Clinicopathological significance of CD28 overexpression in adult T‐cell leukemia/lymphoma

Yuma Sakamoto, Takashi Ishida, Ayako Masaki, Morishige Takeshita et autres

CD28, one of the costimulatory molecules, has a pivotal role in T-cell activation, and its expression is strictly regulated in normal T cells. Gain-of-function genetic alterations involving CD28 have been frequently observed in adult T-cell leukemia/lymphoma (ATLL). These abnormalities, such as CD28 …

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Clinical significance of TP53 mutations in adult T‐cell leukemia/lymphoma

Yuma Sakamoto, Takashi Ishida, Ayako Masaki, Takayuki Murase et autres

Adult T-cell leukaemia/lymphoma (ATL) patients have a poor prognosis. Here, we investigated the impact of TP53 gene mutations on prognosis of ATL treated in different ways. Among 177 patients, we identified 47 single nucleotide variants or insertion-deletions (SNVs/indels) of the TP53 gene …

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A case of basal cell carcinoma from a fistula of an abdominal surgical scar

Yoko KAMITOMO, Koichiro Takeda, Mariko Tamai, Hiroko Sato et autres

76歳，女性。25歳時に帝王切開術施行後，出血のため再開腹術を受けた。手術瘢痕の一部に繰り返す滲出液があり，その後色素斑が出現したが放置していた。初診時，上腹部の手術瘢痕上に瘻孔を認め，瘻孔の下方に隣接して一部黒色斑，結節を伴う紅斑局面を認めた。皮膚生検の病理所見から基底細胞癌と診断した。MRIでは瘻孔下端が白線直下まで達していた。全身麻酔下に腹膜脂肪組織を含めて腫瘍を切除した。切除断端は陰性で術後1年半再発なく経過している。切除標本の組織を詳細に観察すると，腫瘍胞巣の一部が瘻孔壁と連続しており瘻孔から発生した基底細胞癌と診断した。術後の瘢痕から生じた基底細胞癌と，瘻孔を伴う，または瘻孔から生じた基底細胞癌の症例は，いずれも少数の報告がある。術後の瘢痕部に瘻孔が生じそこから基底細胞癌が生じた例はこれまで報告がなく，稀少な症例であると考え若干の文献的考察を交えて報告する。

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A case of CD4/CD8 double－negative mycosis fungoides

Yoko KAMITOMO, Kentaro Yonekura, Yukie Tashiro, Kenjiro Ninomiya et autres

60歳，男性。7年前に腹部に紅斑が出現し，徐々に拡大した。初診時，体幹，四肢に，軽度の鱗屑を伴う境界明瞭なびまん性紅斑，および紅斑局面を認めた。皮膚生検の病理では，表皮内に異型リンパ球の浸潤およびPautrier微小膿瘍を認めた。免疫染色では，CD2（＋），CD3（＋），CD4（－），CD5（＋），CD8（－），CD45RO（－），CD56（－），CCR4（－），TIA－1（－）であった。CD7は，腫瘍細胞の約40％に欠失がみられた。Ki－67陽性率は10％未満であった。CD4，CD8陰性の菌状息肉症と診断した。リンパ節病変，他臓器病変，末梢血病変は認めず，Stage ⅠB（T2bN0M0B0）と診断し，ステロイド外用，紫外線療法を開始した。CD4/CD8 double－negative菌状息肉症は非常に稀な免疫表現型であり，若干の文献的考察を交えて報告する。

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Clinical significance of CD28 gene‐related activating alterations in adult T‐cell leukaemia/lymphoma

Yuma Sakamoto, Takashi Ishida, Ayako Masaki, Morishige Takeshita et autres

Multiple oncogenic events are involved in the development of adult T-cell leukaemia/lymphoma (ATL). Because CD28 plays a pivotal role in T-cell activation, we focused on alterations of the CD28 gene in ATL. We found multiple genetic abnormalities related to CD28 among the …

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Immunohistochemistry for CCR4 C‐terminus predicts CCR4 mutations and mogamulizumab efficacy in adult T‐cell leukemia/lymphoma

Keiichiro Fujii, Yuma Sakamoto, Ayako Masaki, Takayuki Murase et autres

Mogamulizumab targets extracellular N-terminal domain of CCR4, which is expressed in most adult T-cell leukemia/lymphoma (ATL) cases. Recently, we reported that CCR4 C-terminal gain-of-function mutations were frequent in ATL cases, and a subgroup with these mutations who were treated without allogenic hematopoietic …

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長期間のMycobacterium avium菌血症,高HIV RNA,HBV感染,カポジ肉腫,サイトメガロウイルス網膜炎を合併したAIDS患者の治療の成功

Yoshitaka Furukawa, Hamada Heiichiro, Kamikawaji Kazuto, Unoki Taiji et autres