Takuro Kameda

The requirement of MALT1 activity for the growth of adult T cell leukemia/lymphoma

Ayako Kamiunten, Daisuke Morishita, Takuro Kameda, Midori Sugiyama et autres

Adult T cell leukemia/lymphoma (ATL) is an aggressive T cell malignancy with poor prognosis. Recurrent genetic alterations in T cell receptor (TCR) signaling components, including PLCG1 , PRKCB , and CARD11 , highlight the biological relevance of this pathway in ATL. We …

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Fibrocytes drive JAK2V617F-mutated myelofibrosis: pitavastatin reverses marrow fibrosis and anemia

Taisuke Uchida, Kotaro Shide, Takuro Kameda, Yoshinori Ozono et autres

Bone marrow (BM) fibrosis in primary and post-polycythemia vera/essential thrombocythemia myelofibrosis (MF) has traditionally been considered a reactive process driven by cytokines, such as transforming growth factor (TGF)-β1, primarily produced by neoplastic megakaryocytes and platelets. These cytokines promote the differentiation of wild-type …

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FDXR Upregulation by p63/p73 is a Prognostic and Therapeutic Marker of HTLV-1-Associated Adult T Cell Leukemia/Lymphoma

Lara Gallucci, Maria Josephine, Yasunori Kogure, Alex Ap. Rosini Silva et autres

Abstract Infection with human T-lymphotropic virus 1 (HTLV-1) can lead to severe diseases, including adult T-cell leukemia/lymphoma (ATL), for which current therapies are inadequate. HTLV-1 persists chronically through integration of its genome into host DNA and expansion of infected clones via cellular …

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A mouse model of aggressive ATL associated with oncogenic mutations and an HBZ-expressing hematopoietic environment

Takuro Kameda, Kotaro Shide, Yuki Tahira, Taisuke Uchida et autres

Abstract [Introduction] Adult T-cell leukemia/lymphoma (ATL) is a peripheral T-cell malignancy that develops decades after HTLV-1 infection. ATL cells show characteristic “flower cell” morphology and express CD4⁺CD25⁺ Treg-like markers. Aggressive ATL is characterized by uncontrolled proliferation, tissue infiltration, and poor prognosis. In …

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Prognostic value of lymphocyte-to-monocyte ratio in relapsed/refractory adult T-cell Leukemia/lymphoma patients receiving mogamulizumab

Yutaka Shimazu, Takuro Kameda, Ayako Kamiunten, Masaaki Sekine et autres

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Effects of tucidinostat in adult T-cell leukemia/lymphoma in clinical practice

Ayako Kamiunten, Takuro Kameda, Masaaki Sekine, Hiroshi Kawano et autres

Adult T-cell leukemia/lymphoma (ATL) is a peripheral T-cell malignancy with a poor prognosis. We conducted a retrospective study across six institutions in Miyazaki Prefecture, Japan, to assess the efficacy of tucidinostat in patients with relapsed/refractory ATL who had not undergone transplantation. Between …

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TYK2 is essential for the therapeutic effect of IFN-α in Jak2V617F-induced murine myeloproliferative neoplasms

Yuki Tahira, Kotaro Shide, Takuro Kameda, Taisuke Uchida et autres

• TYK2 is essential for the amelioration of MPN features by IFN-α • The mechanism of IFN-α action is different between Jak2 V617F HSCs and Jak2 V617F progenitors Interferon (IFN)-α exhibits antiviral and antiproliferative effects on normal and neoplastic cells. Intracellular signaling …

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【白血病・リンパ腫 臨床現場で役立つ白血病・リンパ腫の最新の知識】さまざまな白血病・リンパ腫病型における診療のポイント 骨髄増殖性腫瘍の診断と治療

Takuro Kameda, Kazuya Shimoda

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Impact of Cooperating Myeloid Gene Mutations on Disease Progression and Survival in Japanese MPN Patients: A Multicenter Study

Kotaro Shide, Masami Takeuchi, Kosei Matsue, Takuro Kameda et autres

In addition to driver mutations such as JAK2, CALR, and MPL, some patients with Polycythemia vera (PV), Essential thrombocythemia (ET), and Primary myelofibrosis (PMF) also have mutations common to other myeloid tumors. We conducted this study from 2018 to clarify the impact …

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Prevalence of chromosome 8p11.2 translocations and correlation with myeloid and lymphoid neoplasms associated with FGFR1 abnormalities in a consecutive cohort from nine institutions in Japan

Kensuke Usuki, Takuro Kameda, Noriaki Kawano, Tomoki� Ito et autres

Myeloid and lymphoid neoplasms associated with FGFR1 abnormalities (MLN-FGFR1 abnormalities) are rare hematologic malignancies associated with chromosome 8p11.2 abnormalities. Translocations of 8p11.2 were detected in 10 of 17,039 (0.06%) unique patient cytogenetic studies performed at nine institutions in Japan. No inversions or …

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Impaired humoral immunity following COVID-19 vaccination in HTLV-1 carriers

Takuro Kameda, Atae Utsunomiya, N. Otsuka, Yoko Kubuki et autres

BACKGROUND: Whether human T-lymphotropic virus type 1 (HTLV-1) carriers can develop sufficient humoral immunity after coronavirus disease 2019 (COVID-19) vaccination is unknown. METHODS: To investigate humoral immunity after COVID-19 vaccination in HTLV-1 carriers, a multicenter, prospective observational cohort study was conducted at …

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Real-world clinical characteristics of post-essential thrombocythemia and post-polycythemia vera myelofibrosis

Kotaro Shide, Katsuto Takenaka, Akira Kitanaka, Akihiko Numata et autres

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