Ge Bai

Leveraging plasma concentrations to optimize extracorporeal treatment in acute diquat poisoning: a multi-center retrospective cohort study

Yuewei Ling, Zhengsheng Mao, Chuhan Zhou, Jinquan Li et autres

INTRODUCTION: Diquat poisoning is common in Asia and the optimal enhanced elimination strategy is unknown. This study aimed to evaluate the clinical value of plasma diquat concentrations in guiding personalized extracorporeal treatment regimens for patients with acute diquat poisoning. METHODS: This multi-center …

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Optimization of Pseudotargeted Metabolomics: Fully Integrating the Advantages of Both Targeted and Untargeted Approaches

Yong Li, Pang Tao, Junli Shi, Zhenmin Xu et autres

Introduction: This study aimed to address persistent challenges in pseudotargeted metabolomics, particularly the limited compatibility with diverse sample types, by developing an enhanced method integrating the strengths of targeted and untargeted approaches. Methods: An upgraded pseudotargeted metabolomics method was developed, incorporating a …

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SAT-396 Scenario Changing and Efficacy of Therapeutic Plasma Exchange in the Treatment of Thyrotoxicosis

Zirui Zhu, Xinran Gao, Ge Bai, Honghua Wu et autres

Abstract Disclosure: Z. Zhu: None. X. Gao: None. G. Bai: None. H. Wu: None. Y. Huang: None. J. Zhang: None. Y. Gao: None. Y. Zhang: None. Background: Current guidelines primarily recommend TPE for thyroid storm, with limited recommendations for other indications of …

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PACAP inhibits high fat-induced NLRP3 inflammasome-mediated pyroptosis in vascular endothelial cells by regulating the SIRT1/ROS pathway

Tianyu Ma, Yan Qu, Runquan Ye, Jia Feng et autres

cn (code pays fourni par la source)

ZNF468/AURKA/PI3K/AKT Positive Feedback Loop Promotes Proliferation and Metastasis of Oesophageal Squamous Cell Carcinoma

Ge Bai, Lei Wang, Li Zhang

While prior research linked ZNF468 to radioresistance in oesophageal squamous cell carcinoma (ESCC), its broader role in ESCC progression remained unclear. This study elucidates these functions and underlying mechanisms. Immunohistochemistry on clinical ESCC tissues demonstrated ZNF468 upregulation, which correlated with unfavourable patient …

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Integration of metabolic and transcriptomic analyses for revealing the galactose metabolism of tobacco (Nicotiana tabacum) under salt stress

Ge Bai, Hui Zhang, Yong Hui Li, Da‐Hai Yang et autres

Background: Soil salinization poses a global threat to agriculture, necessitating strategies to enhance plant salt stress tolerance. Understanding the metabolic and transcriptomic responses of tobacco plants to salt stress is crucial for developing such strategies. Results: This study identified 238 up-regulated and …

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WHEP Domain of Glycyl-tRNA Synthetase Regulates Neuropilin 1 Binding and Vascular Permeability

Yao Tong, Noemi Gioelli, Huimin Zhang, Calin Dan Dumitru et autres

Abstract Aminoacyl-tRNA synthetases (aaRSs) charge tRNAs with their cognate amino acids, ensuring accurate translation of the genetic code from mRNA to protein. During eukaryotic evolution, aaRSs acquired additional domains with unclear functions, including the WHEP domain, a two-helix bundle found in several …

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Prox1 Protein in Corneal Limbal Lymphatic Vessels Maintains Limbal Stem Cell Stemness and Regulates Corneal Injury Repair

An Wang, Zongyuan Li, Yilin Jiang, Mingxiong Chen et autres

Purpose: The purpose of this study was to elucidate the role of the corneal lymphatic Prox1 gene in modulating limbal stem cell stemness and facilitating corneal injury repair. Methods: The limbal Prox1 gene was knocked down by adeno-associated virus (AAV). The alkali …

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Severity Indices of Diquat Poisoning for Triage and Prognosis in Acute Diquat Poisoning: A Multicenter Prospective Cohort Study

Yuewei Ling, Zhengsheng Mao, Wen Liu, Chuhan Zhou et autres

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A STING agonist prodrug reprograms tumor-associated macrophage to boost colorectal cancer immunotherapy

Aohua Deng, Renming Fan, Yongrui Hai, Junyan Zhuang et autres

By targeting TREM2 and activating the STING signaling pathway in TAMs, prodrug GB2 exhibits excellent anti-tumor efficacy and immune-activating capacity in the mouse colon cancer model.

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PACIENTE COM ANEMIA APLÁSICA E CLONE DE HEMOGLOBINÚRIA PAROXÍSTICA NOTURNA EVOLUINDO PARA LEUCEMIA MIELOIDE AGUDA.

Ge Bai, Bhanu Kumar M, N F, A A et autres

A hemoglobinúria paroxística noturna (HPN) é uma doença cuja fisiopatologia decorre de um defeito mutacional em um clone de célula tronco hematopoiética. Esta mutação ocorre no gene da fosfaditilinositollglicana, que resulta no bloqueio precoce da síntese de âncoras de glicosilfosfaditilinositol (GPI), responsável …

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Boronic ester bonds hydrogel with temperature and pH responsiveness for controlled release fertilizer

Lan Li, Ge Bai, Wanjun Gu, Chunhua Niu et autres

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