Yi Guo

OTU deubiquitinases as immune-circuit editors: from human immunopathology to therapeutic prioritization

Yi Guo, Yue Song, Chenxin Wang, Rui Xiong et autres

OTU deubiquitinases are linkage-sensitive ubiquitin editors that regulate immune circuits, human immunopathology, and emerging therapeutic opportunities. By remodeling K48-, K63-, and linear ubiquitin chains, they control protein stability, scaffold assembly, and signal amplitude across nuclear factor κB (NF-κB), and tumor-immune pathways. Individual …

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The leaked mitochondrial DNA activated the cGAS-STING signaling pathway and exacerbated the motor dysfunction in mice caused by MPTP

Guangyao Zhu, Xuanjie Yu, Yi Guo, Liting Yang et autres

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TRPV1-tau axis: A bidirectional regulatory mechanism linking pain sensitization and Alzheimer's disease progression and its potential for intervention

Liangliang Shi, Jin Yang, Yi Guo, Yi Guo et autres

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