Jushan Wu

Identification of Salivary Exosome-Derived miRNAs as Potential Biomarkers for Non-Invasive Diagnosis and Proactive Monitoring of Inflammatory Bowel Disease

Congyi Yang, Jingyi Chen, Yalan Xu, Jushan Wu et autres

Inflammatory bowel disease (IBD), a chronic inflammatory disorder with relapsing/remitting characteristics, lacks reliable non-invasive biomarkers for accurate diagnosis and longitudinal monitoring. This study explored salivary exosomal miRNAs as potential biomarkers to address this unmet clinical need. Using discovery (24 IBD patients [11 …

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Gut microbiota, plasma metabolites, and venous thromboembolism: a Mendelian randomization study

Jinxi Wang, Jushan Wu, Guangming Li

Emerging evidence links gut microbiota (GM) to venous thromboembolism (VTE), deep vein thrombosis (DVT), and pulmonary embolism (PE), but causal insights are limited. Using two-sample Mendelian randomization (MR), we assessed causal effects of 211 GM taxa and 489 plasma metabolites on VTE/DVT/PE. …

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Phosphoproteomics delineates hepatocellular carcinoma subtypes and pinpoints therapeutic targets

Zhenpeng Zhang, Kaixuan Li, Yanchang Li, Xuehui Peng et autres

BACKGROUND AND AIMS: Only a minority of patients could benefit from systemic therapy owing to the high heterogeneity of HCC. Therefore, a deeper understanding of the pathogenesis of HCC is essential for precision therapy. Genomic and proteomic studies of HCC have enhanced …

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Five-year complete remission of super-giant hepatocellular carcinoma with hepatectomy followed by sorafenib plus camrelizumab: A case report

Xiaoqin Zheng, Libo Sun, Wenjie Jin, Hui Liu et autres

BACKGROUND: Cirrhotic patients with super-giant hepatocellular carcinoma (HCC) and portal vein invasion generally have a poor prognosis. This paper presents a patient with super-giant HCC and portal vein invasion, who underwent hepatectomy followed by a combination of sorafenib and camrelizumab, resulting in …

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Chinese expert consensus on sequential surgery following conversion therapy based on combination of immune checkpoint inhibitors and antiangiogenic targeted drugs for advanced hepatocellular carcinoma (2024 edition)

Haowen Tang, Wenwen Zhang, Junning Cao, Yinbiao Cao et autres

Up to half of hepatocellular carcinoma (HCC) cases are diagnosed at an advanced stage, for which effective treatment options are lacking, resulting in a poor prognosis. Over the past few years, the combination of immune checkpoint inhibitors and anti-angiogenic targeted therapy has …

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Salivary exosomes exacerbate colitis by bridging the oral cavity and intestine

Congyi Yang, Jingyi Chen, Yuzheng Zhao, Jushan Wu et autres

Inflammatory bowel disease (IBD) presents a range of extraintestinal manifestations, notably including oral cavity involvement. The mechanisms underlying oral-gut crosstalk in IBD are not fully understood. Exosomes, found in various body fluids such as saliva, play an unclear role in IBD that …

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LONP1 ameliorates liver injury and improves gluconeogenesis dysfunction in acute-on-chronic liver failure

Muchen Wu, Jing Wu, Kai Liu, Minjie Jiang et autres

BACKGROUND: Acute-on-chronic liver failure (ACLF) is a severe liver disease with complex pathogenesis. Clinical hypoglycemia is common in patients with ACLF and often predicts a worse prognosis. Accumulating evidence suggests that glucose metabolic disturbance, especially gluconeogenesis dysfunction, plays a critical role in …

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Prediction Model for Immunotherapy Efficacy in Hepatocellular Carcinoma Based on Alternative Splicing Sequencing Data

Huizhong Shi, Yang Liu, Zhao Liu, Xinlan Ge et autres

Background: Integrating immune checkpoint inhibitors with multi-target tyrosine kinase inhibitors presents an innovative and hopeful strategy in liver cancer treatment. Nonetheless, a degree of resistance to this treatment is noticeable in certain patients. Alternative splicing (AS) represents a common biological process that …

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Macrophage-Derived Cathepsin S Remodels the Extracellular Matrix to Promote Liver Fibrogenesis

Tao Zuo, Qi Xie, Jinfang Liu, Jing Yang et autres

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Identification of a prognostic signature model for predicting disease-free survival of hepatocellular carcinoma.

Guangming Li, Huanhuan Liu, Daobing Zeng, Menglong Wang et autres

e16128 Background: Hepatocellular carcinoma (HCC) is a type of aggressive disease with poor prognosis. Although surgery is the most effective therapy for early liver cancer, recurrence rate is up to 50%. Therefore, it is crucial to predict the recurrence for improvement of …

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Molecular characteristics of patients with resectable hepatocellular carcinoma.

Daobing Zeng, Menglong Wang, Jushan Wu, Dongdong Lin et autres

e16140 Background: Hepatocellular carcinoma (HCC) is one of the most common malignancies and leading cause of cancer deaths worldwide. Biomarkers contribute to predict the response of targeted treatments and immunotherapy. Therapy directed toward homologous recombination deficiency (HRD) is now approved in ovarian …

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Diagnosis and treatment of acute graft-versus-host disease after liver transplantation: A report of 11cases

Xiaofei Zhao, Dongdong Lin, Ning Li, Jushan Wu et autres

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