Youliang Sun

Targeting TET3 suppresses group 3 medulloblastoma stemness and progression via impairing hypomethylation of Otx2 super-enhancer

Xuan Chen, Ziwei Wang, Yan Song, Yu Su et autres

Medulloblastoma (MB), particularly Group_3 (G3-MB), remains the most aggressive subgroup due to strong stemness and therapeutic resistance. Through genome-wide DNA methylation and transcriptomic analysis of human MB samples, we identify enhancer hypomethylation as a key feature sustaining G3-MB stemness and tumor progression. …

cn, hk, ca, fr, de (code pays fourni par la source)

High cellular plasticity state of medulloblastoma local recurrence and distant dissemination

Hailong Liu, Jing Zhang, Ziwei Wang, Wei Wang et autres

Medulloblastoma (MB), a heterogeneous pediatric brain tumor, poses challenges in the treatment of tumor recurrence and dissemination. To characterize cellular diversity and genetic features, we comprehensively analyzed single-cell/nucleus RNA sequencing (sc/snRNA-seq), single-nucleus assay for transposase-accessible chromatin sequencing (snATAC-seq), and spatial transcriptomics profiles …

cn, ca, us, fr, de, hk (code pays fourni par la source)

Study on the Temperature Effect on the Internal Electric Field Distribution and Discharge Mechanism of Converter Transformer Under Ac-Dc Composite Voltage

Ze Li, Fuqiang Ren, Dongxin He, Shuqi Li et autres

cn, Égypte (code pays fourni par la source)

Evaluation and Optimization Schemes of Eddy Current Loss on Structural Components for High Voltage Converter Transformer

Min Xuan Shen, Penghong Guo, Yanling Wang, Youliang Sun et autres

cn (code pays fourni par la source)

Research on Internal Sound Field Distribution of Transformer Under Hot Spot Fault

Pan Geng, Penghong Guo, Youliang Sun, Haoxin Guo et autres

The existing transformer hot spot temperature measurement method is limited by the shielding of its metal shell and the complexity of its internal structure. In order to solve this problem, researches have begun to apply acoustic temperature measurement technology to the field …

cn (code pays fourni par la source)

Supplementary Table 1 from MELK and EZH2 Cooperate to Regulate Medulloblastoma Cancer Stem-like Cell Proliferation and Differentiation

Hailong Liu, Qianwen Sun, Youliang Sun, Junping Zhang et autres

Table S1. Univariate and multivariate analysis by Cox proportional model.

Supplementary figure legends from MELK and EZH2 Cooperate to Regulate Medulloblastoma Cancer Stem-like Cell Proliferation and Differentiation

Hailong Liu, Qianwen Sun, Youliang Sun, Junping Zhang et autres

supplementary figure legends.

Supplementary Figure 6 from MELK and EZH2 Cooperate to Regulate Medulloblastoma Cancer Stem-like Cell Proliferation and Differentiation

Hailong Liu, Qianwen Sun, Youliang Sun, Junping Zhang et autres

The pathological characteristics about MB25550 showed the classic (left) and SHH (right) subgroups.

Supplementary Figure 4 from MELK and EZH2 Cooperate to Regulate Medulloblastoma Cancer Stem-like Cell Proliferation and Differentiation

Hailong Liu, Qianwen Sun, Youliang Sun, Junping Zhang et autres

Western blot analysis showed the elimination of MELK and EZH2 by being infected with lentivirus encoding shMELK, shEZH2 in comparison to no-target shRNA.

Supplementary Figure 2 from MELK and EZH2 Cooperate to Regulate Medulloblastoma Cancer Stem-like Cell Proliferation and Differentiation

Hailong Liu, Qianwen Sun, Youliang Sun, Junping Zhang et autres

H.E. staining for the intracranial xenograft derived from the MB25550 CSCs.

Supplementary Figure 1 from MELK and EZH2 Cooperate to Regulate Medulloblastoma Cancer Stem-like Cell Proliferation and Differentiation

Hailong Liu, Qianwen Sun, Youliang Sun, Junping Zhang et autres

A-B, Expression of MELK and EZH2 in pan-cancers from TCGA database. C, Correlation between MELK and EZH2 in SHH associated MB from GSE50765 dataset. D, Correlation between MELK and EZH2 mRNA relative expression in GBM from TCGA database.

Supplementary Figure 5 from MELK and EZH2 Cooperate to Regulate Medulloblastoma Cancer Stem-like Cell Proliferation and Differentiation

Hailong Liu, Qianwen Sun, Youliang Sun, Junping Zhang et autres

Daoy CSCs were treated with the indicated concentration of OTSSP167, DZNep and combination of both inhibitors for 42 h and proliferation was measured by MTT. No significant differences existed in the three therapeutic groups (p = 0.31).