Jinlian Wang

Natural-product polypharmacology in acute lymphoblastic leukemia: a state-of-the-art review

Jinlian Wang, Yi-Xiang Wang, Fang Wang, Ying Zhou et autres

cn (code pays fourni par la source)

Ketogenic diet improves cognitive impairment in rats with temporal lobe epilepsy by activating the Nrf2/HO-1/GPX4 signaling axis to inhibit ferroptosis

Lin Yang, Jinlian Wang, Xuhui Wang, Bianli Li et autres

cn (code pays fourni par la source)

Rewiring the regulated cell death network in diabetic retinopathy: natural products as system-level modulators

Qun Huang, Tingru Chen, fang Wang, Jieying Wang et autres

cn (code pays fourni par la source)

Discovering signature disease trajectories in pancreatic cancer and soft-tissue sarcoma from longitudinal patient records

Liwei Wang, Rui Li, Andrew Wen, Qingli Lu et autres

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Discovering Signature Disease Trajectories in Pancreatic Cancer and Soft-tissue Sarcoma from Longitudinal Patient Records

Liwei Wang, Rui Li, Andrew Wen, Qingli Lu et autres

Understanding the disease trajectories of specific diseases can provide important clinical insights. In this paper, we aimed to discover signature disease trajectories of 3 rare cancer types: pancreatic cancer, soft tissue sarcoma (STS) of the trunk and extremity (STS-TE), and STS of …

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Harnessing natural saponins: Advancements in mitochondrial dysfunction and therapeutic applications

Hongmei Liu, Huan Wang, Xinyu Lin, Min Xu et autres

cn (code pays fourni par la source)

An Informatics Framework for Accelerating Digital Health Technology Enabled Randomized Controlled Trial Candidate Guideline Item Development

Di Hu, Heling Jia, Shyang Hong Tan, Fang Chen et autres

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Empowering Precision Medicine for Rare Diseases through Cloud Infrastructure Refactoring.

Huijun Li, Jinlian Wang, Hongfang Liu

Rare diseases affect approximately 1 in 11 Americans, yet their diagnosis remains challenging due to limited clinical evidence, low awareness, and lack of definitive treatments. Our project aims to accelerate rare disease diagnosis by developing a comprehensive informatics framework leveraging data mining, …

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Assessing Geographic Diversity in Systematic Reviews: A 3D Interactive Approach Using Cochrane SRs in IPF.

Huijun Li, Jinlian Wang, Hongfang Liu

The Systematic reviews (SRs) for Idiopathic Pulmonary Fibrosis (IPF) play a crucial role in guiding evidence-based healthcare by synthesizing data across multiple studies. A key factor in ensuring the reliability and applicability of these reviews is the geographic diversity of the authors …

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Inner Mitochondrial Membrane Peptidase 2-Like Deletion Aggravates Mitochondrial Apoptosis and Inhibits Autophagy After Hyperglycemia Stroke

Ning Ma, Xiaohong Luo, Jianan Wang, Shihui Sun et autres

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The role of polyphenols in modulating mitophagy: Implications for therapeutic interventions

Xinyu Lin, Wenkai Liu, Xizhuo Hu, Zhiqiang Liu et autres

This review rigorously assesses the burgeoning research into the role of polyphenols in modulating mitophagy, an essential cellular mechanism for the targeted removal of impaired mitochondria. These natural compounds, known for their low toxicity, are underscored for their potential in therapeutic strategies …

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Prioritizing Clinically Significant Lung Cancer Somatic Mutations for Targeted Therapy Through Efficient NGS Data Filtering System.

Jinlian Wang, Hui Li, Hongfang Liu

In the realm of lung cancer treatment, where genetic heterogeneity presents formidable challenges, precision oncology demands an exacting approach to identify and hierarchically sort clinically significant somatic mutations. Current Next-Generation Sequencing (NGS) data filtering pipelines, while utilizing various external databases for mutation …

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