Jia Dai

Three-dimensional genome architecture in intrahepatic cholangiocarcinoma

Youfeng Liang, Cong Li, Renchao Zou, Ying Lü et autres

PURPOSE: Intrahepatic cholangiocarcinoma (ICC) is a common primary hepatic tumors with a 5-year survival rate of less than 20%. Therefore, it is crucial to elucidate the molecular mechanisms of ICC. Recently, the advance of high-throughput chromosome conformation capture (Hi-C) technology help us …

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DHT deteriorates the progression of monocrotaline-induced pulmonary arterial hypertension: effects of endogenous and exogenous androgen.

Juan Wen, Jiajie Wang, Xiaohong Tang, Shangbin Deng et autres

Pulmonary arterial hypertension (PAH) is more popular among females than males. However, female patients exhibit better prognosis than men, sex hormones may partly explain such sex paradox. Estrogens are disease modifiers in PAH, androgen effects on PAH are yet incompletely characterized. In …

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Effects of arterial blood on the venous blood vessel wall and differences in percentages of lymphocytes and neutrophils between arterial and venous blood

Liping Peng, Wen Juan, Kan Yang, Shaoli Zhao et autres

Vascular sclerosis mostly occurs in arteries and is mainly related to anatomic structure and hemodynamics of artery. This study aimed to investigate effects of arterial blood on vein wall and explore differences of composition between arterial and venous blood.Ultrasound was used to …

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T-bet deficiency attenuates cardiac remodelling in rats

Zhen‐Guo Ma, Jia Dai, Yu‐Pei Yuan, Zhou‐Yan Bian et autres

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Protection against cardiac hypertrophy by geniposide involves the GLP‐1 receptor / AMPKα signalling pathway

Zhen‐Guo Ma, Jia Dai, Wenbin Zhang, Yuan Yuan et autres

BACKGROUND AND PURPOSE: Activation of glucagon-like peptide-1 (GLP-1) receptor exerts a range of cardioprotective effects. Geniposide is an agonist of GLP-1 receptor, but its role in cardiac hypertrophy remains completely unknown. Here, we have investigated its protective effects and clarified the underlying …

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Asiatic Acid Protects against Cardiac Hypertrophy through Activating AMPKα Signalling Pathway

Zhen‐Guo Ma, Jia Dai, Wenying Wei, Wenbin Zhang et autres

BACKGROUND: AMPactivated protein kinase α (AMPKα) is closely involved in the process of cardiac hypertrophy. Asiatic acid (AA), a pentacyclic triterpene, was found to activate AMPKα in our preliminary experiment. However, its effects on the development of cardiac hypertrophy remain unclear. The …

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Geniposide Protects against Cardiac Hypertrophy via GLP-1R/AMPKα Signalling Pathway: Geniposide Protects against Cardiac Hypertrophy

Zhen‐Guo Ma, Jia Dai, Wenbin Zhang, Yuan Yuan et autres

ATF3: A potential target for cardiac maladaptive remodeling

Zhen‐Guo Ma, Wenying Wei, Si‐Chi Xu, Wenbin Zhang et autres

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Icariin protects H9c2 cardiomyocytes from lipopolysaccharide-induced injury via inhibition of the reactive oxygen species-dependent c-Jun N-terminal kinases/nuclear factor-κB pathway

Heng Zhou, Yuan Yuan, Yuan Liu, Jian Ni et autres

The inflammatory response is involved in the pathogenesis of the most common forms of heart disease. Icariin has a number of pharmacological actions, including anti‑inflammatory, anti‑oxidative and anti‑apoptotic effects. However, the role of icariin in cardiac inflammation has remained elusive. In the …

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IRAK4 deficiency promotes cardiac remodeling induced by pressure overload.

Yuan Yuan, Hua-Wen Gan, Jia Dai, Heng Zhou et autres

BACKGROUND: Interluekin1 receptor-associated kinase-4 (IRAK4) plays an essential role in the innate immune system. The aim of this study was to investigate the role of IRAK4 in cardiac remodeling induced by pressure overload and elucidate the underlying mechanisms. METHODS: In vivo studies …

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GW25-e3225 Role of Cathepsin B in the regulation of cardiac remodeling

Qingqing Wu, Man Xu, Yuan Yuan, Fangfang Li et autres

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ATF3 regulates multiple targets and may play a dual role in cardiac hypertrophy and injury

Heng Zhou, Haipeng Guo, Jing Feng Zong, Jia Dai et autres

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