Sofia Morais

Plasma IL-17A, IFN-γ, and MIP-3α profiles are associated with clinical stage transition in first-episode psychosis

Miguel Rosado, Catarina Empadinhas, Vitor Santos, Cátia Santa et autres

Background: Early detection of individuals at risk for clinical deterioration in first-episode psychosis (FEP) remains a vital challenge in psychiatric care. Emerging evidence indicates that immune dysregulation might play a crucial role in the pathophysiology and progression of psychotic disorders. This study …

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SGLT2i Treatment Modulates Tacrolimus-Mediated Nephrotoxicity

Sofia Morais, Huiqiang Wei, Farida Hayati, Roslyn Bernstein Mannon

Purpose: Tacrolimus (TAC) remains an important immunosuppressive agent despite its nephrotoxicity. Prior studies have shown that Tac mediates injury in part by promoting oxidative stress and mitochondrial dysfunction in the kidney. Recently, SGLT2 inhibitors (SGLT2i) have been shown to have cardiorenal protective …

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Oncolytic viral therapy with Zika: a promising alternative for glioblastoma treatment

L. M. Souza, Stephanie Zarlotim Jorge, Nicolle Divanenko, Giovanna Soares Correa et autres

Padrões de Prescrição na PHDA no Adulto: A Realidade do CHUC

Isabela Faria, Sofia Morais, Carla Silva, Nuno Gonçalo Gomes Fernandes Madeira

Introdução: A perturbação de hiperatividade e défice de atenção (PHDA) é uma das patologias neuropsiquiátricas mais comuns, afetando cerca de 2%‑4% da população adulta. A intervenção farmacoterapêutica de primeira linha são os psicoestimulantes como o metilfenidato e as anfetaminas. Geralmente, A terapêutica …

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Diagnostic delays in schizophrenia with catatonic symptoms mimicking conversive disorder

Justin R. Fernandes, Nishma Monteiro, Sofia Morais, J. Brás

Introduction Notwithstanding the drastic reduction in the prevalence of catatonic symptoms in schizophrenia with the development of anti-psychotic treatment regimens since the 1950’s, a subgroup of patients still presents mostly such symptoms, associated with worse long-term prognosis. Objectives Discuss the challenges surrounding …

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First Episode Psychosis: A Neurodevelopmental Crossroads

Nishma Monteiro, Mariana de Lyra Vasconcelos, Rosa Resende, Sofia Morais et autres

Introduction Autism spectrum disorder (ASD) and schizophrenia (SZ) are neurodevelopmental disorders that, although unfolding in different ways, can present with overlapping symptoms, both negative symptoms like deficits in social–emotional reciprocity and engagement (Trevisan et al. Front.Psych; 2020;11:548), and positive symptoms like delusions …

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Schizophrenia versus Traumatic Brain Injury: A Diagnostic Challenge

Nishma Monteiro, Marta Abrantes, Sofia Morais

Introduction Traumatic brain injury (TBI) is a rare, yet possible cause of psychosis (Fujii D et al. Psychiatr Clin North Am. 2014; 37(1):113-24), with one of the main challenges being distinguishing between Psychosis secondary to traumatic brain injury (PSTBI) and schizophrenia (SZ). …

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Is there a place for Psychosocial Rehabilitation in Alcohol Use Disorders? – A Retrospective Analysis of the profile of frequent Users of an Inpatient Alcohol Unit in Lisbon

Maria Sandra Andrade, Maria do Rosário Cameira, Isabela Martins Becattini Pereira, Ana Cristina Ferreira et autres

Introduction Alcohol dependence is a chronic condition associated with multiple relapses, leading to recurrent admissions to inpatient units. The success of treatment is closely tied to the psychosocial rehabilitation of these patients, as a means to ensure long-term abstinence. Objectives We aim …

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Improving Access to Mental Health Care through a Stepped Care Approach: Preliminary Results from a University Students’ Sample

Marisa Marques, Sofia Caetano, Sandra Xavier, Ana Teixeira de Melo et autres

Introduction: Recently, university counseling services have been faced with an increasing number of students seeking psychological support. However, human resources and time constraints limit the services to respond adequately. Recently, national guidelines for Mental Health Services in Higher Education recommended the stepped …

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Proteomic analysis of peripheral blood mononuclear cells in first episode psychosis – Protein and peptide-centered approaches to elucidate potential diagnostic biomarkers

Cátia Santa, João A. Rodrigues, Ana Martinho, Vera M. Mendes et autres

Diagnosing patients suffering from psychotic disorders is far from being achieved with molecular support, despite all the efforts to study these disorders from different perspectives. Characterizing the proteome of easily obtainable blood specimens, such as the peripheral blood mononuclear cells (PBMCs), has …

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Executive function in schizophrenia and autism in adults shares common components separating high and low performance groups

Sofia Morais, Otília C. d’Almeida, Salomé Caldeira, Sofia Meneses et autres

The profile of executive function (EF) in adults with Schizophrenia (SCZ) and autism spectrum disorder (ASD) remains unclear. This study aims to ascertain if distinct EF patterns can be identified between each clinical condition by comparing the neuropsychological profile of adults with …

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Neurofeedback training of executive function in autism spectrum disorder: distinct effects on brain activity levels and compensatory connectivity changes

Daniela Jardim Pereira, Sofia Morais, Alexandre Sayal, João Pereira et autres

BACKGROUND: Deficits in executive function (EF) are consistently reported in autism spectrum disorders (ASD). Tailored cognitive training tools, such as neurofeedback, focused on executive function enhancement might have a significant impact on the daily life functioning of individuals with ASD. We report …

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