Qun Du

AZD4512: A novel CD22-directed antibody-drug conjugate for the treatment of b-cell malignancies

Huiying Han, Morgann Klink, Kalyani Daita, Rosaria De Filippi et autres

Abstract Despite advances in the treatment of B-cell non-Hodgkin lymphomas (B-NHL) and B-cell acute lymphoblastic leukemia (B-ALL), disease resistance, relapse, and treatment-related toxicities remain significant challenges. Antibody-drug conjugates (ADCs) have transformed the treatment of many cancers by enabling the selective delivery of …

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Enhanced rational protein engineering to reduce viscosity in high-concentration IgG1 antibody solutions

Tyler J. Lefevre, Austin Gallegos, Qun Du, E. R. Houston et autres

Subcutaneous (SC) delivery of therapeutic antibodies can offer multiple benefits to patients and healthcare providers, including convenience, time savings, and cost reduction. To improve the SC injection experience, drug developers may seek a low injection volume (1–2 mL), which for some antibody …

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Qingre Huayu Jianpi decoction suppresses colorectal tumorigenesis by inhibiting cancer stem cells and cancer-associated fibroblasts

Lili Huang, Deng Guifang, Weiqi Lu, Fan Xiao et autres

cn (code pays fourni par la source)

[Mediating effect of sleep duration between depression symptoms and myopia in middle school students].

Wei Du, Runqiang Zeng, Yafei Li, J Wang et autres

OBJECTIVES: To explore the mediating role of sleep duration in the relationship between depression symptoms and myopia among middle school students. METHODS: This study was a cross-sectional research conducted using a stratified cluster random sampling method. A total of 1 728 middle …

cn (code pays fourni par la source)

The relationship between adolescent sleep duration and exposure to school bullying: the masking effect of depressive symptoms

Runqiang Zeng, Dali Han, Wei Du, Jing Wen et autres

Background Adolescents who suffer from school bullying are often accompanied by problems such as sleep disorders and depression. However, it remains unclear how depressive symptoms and sleep assessments such as sleep duration interact in the specific mechanisms of exposure to school bullying. …

cn (code pays fourni par la source)

Anti-oxidative stress and cognitive improvement of a semi-synthetic isoorientin-based GSK-3β inhibitor in rat pheochromocytoma cell PC12 and scopolamine-induced AD model mice via AKT/GSK-3β/Nrf2 pathway

Yijing Zhao, Changhong He, Shaozhen Hu, H. Ni et autres

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Metformin improves cognitive dysfunction through SIRT1/NLRP3 pathway–mediated neuroinflammation in db/db mice

Hu Tian, Jun-Wen Wei, Jiayi Zheng, Qingyi Luo et autres

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Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice

Hongling Lu, Tianhuan Zhou, Qihong Jiang, Chenkai Jiang et autres

seed oil, is a unique Δ5-unsaturated-polymethylene-interrupted fatty acid (Δ5-UPIFA) that has been claimed to counteract such disorders owing to some of its physiological effects. However, the role of SC in ameliorating bone metabolism disorders due to HFD remains unclear. In the present …

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Supplementary Figures 1-14; Supplementary Tables 1-3 from A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non–EGFR-Mediated Pathways

Jonathan Rios‐Doria, Darrin Sabol, Jon Chesebrough, Dave Stewart et autres

Supplementary Figures 1-14; Supplementary Tables 1-3. Supplementary Figure 1. Lead antibody 80PH3 is a potent inhibitor of recombinant ADAM17 Supplementary Figure 2. 80PH3 is not a potent inhibitor of cellular ADAM17 Supplementary Figure 3. MEDI3622 is highly selective for ADAM17 and does …

supplementary figure legends from A Monoclonal Antibody to ADAM17 Inhibits Tumor Growth by Inhibiting EGFR and Non–EGFR-Mediated Pathways

Jonathan Rios‐Doria, Darrin Sabol, Jon Chesebrough, Dave Stewart et autres

supplmentary figure legends

Figures S8-S10 from Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein

Michael D. Oberst, Catherine Augé, Chad D. Morris, Stacy Kentner et autres

Supplementary Figure 8. MEDI6383 enhancement of human CD4 T cell proliferation (CFSE dilution) among CD3 enriched T cells. Supplementary Figure 9. Cell surface expression of OX40 and OX40L on A375 melanoma tumor cells and A375-alloreactive human CD4+ T cells. Supplementary Figure 10. …

Figure S7 from Potent Immune Modulation by MEDI6383, an Engineered Human OX40 Ligand IgG4P Fc Fusion Protein

Michael D. Oberst, Catherine Augé, Chad D. Morris, Stacy Kentner et autres

Regulation of cell surface activation markers on CD4 and CD8 T cells by MEDI6383