Accès ouvert
2025
article
OpenAlex
Tyler J. Lefevre, Austin Gallegos, Qun Du, E. R. Houston et autres
Subcutaneous (SC) delivery of therapeutic antibodies can offer multiple benefits to patients and healthcare providers, including convenience, time savings, and cost reduction. To improve the SC injection experience, drug developers may seek a low injection volume (1–2 mL), which for some antibody …
sg, br, pl, us
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Accès ouvert
2025
article
OpenAlex
Lateefat Kalejaye, Jia‐Min Chu, I-En Wu, Bismark Amofah et autres
Highly concentrated antibody solutions are necessary for developing subcutaneous injections but often exhibit high viscosities, posing challenges in antibody-drug development, manufacturing, and administration. Previous computational models were only limited to a few dozen data points for training, a bottleneck for generalizability. In …
us, br, au
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Andrew Dippel, Austin Gallegos, Vineela Aleti, Arnita Barnes et autres
To combat the COVID-19 pandemic, potential therapies have been developed and moved into clinical trials at an unprecedented pace. Some of the most promising therapies are neutralizing antibodies against SARS-CoV-2. In order to maximize the therapeutic effectiveness of such neutralizing antibodies, Fc …
sg, us, cn, br
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Pin‐Kuang Lai, Austin Gallegos, Neil Mody, Hasige A. Sathish et autres
Machine learning has been recently used to predict therapeutic antibody aggregation rates and viscosity at high concentrations (150 mg/ml). These works focused on commercially available antibodies, which may have been optimized for stability. In this study, we measured accelerated aggregation rates at …
us
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Accès ouvert
2018
article
OpenAlex
Jessica J. Hobson, Austin Gallegos, Benjamin W. Atha, John P. Kelly et autres
Small proteins are a new and expanding area of research. Many characterized small proteins are composed of a single hydrophobic α-helix, and the functional requirements of their limited amino acid sequence are not well understood. One hydrophobic small protein, CydX, has been …
us
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Eric T. Christenson, Austin Gallegos, Anirban Banerjee
Iron is universally important to cellular metabolism, and mitoferrin-1 and -2 have been proposed to be the iron importers of mitochondria, the cell's assembly plant of heme and iron–sulfur clusters. These iron-containing prosthetic groups are critical for a host of physiological processes …
us
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