Yingnan Liu

African swine fever virus pMGF360-3 L suppresses innate immunity by facilitating CMA-dependent SKP1 degradation to promote BNIP3-mediated mitophagy

Sizhan Lin, Jingtao Liang, Jiafang Ye, Minping Chen et autres

African swine fever (ASF) is an acute, hemorrhagic, and highly contagious disease caused by African swine fever virus (ASFV), which causes severe economic losses in the swine industry. ASFV has evolved multiple strategies to evade host antiviral immune responses. Here, we report …

African swine fever virus pMGF360-3 L suppresses innate immunity by facilitating CMA-dependent SKP1 degradation to promote BNIP3-mediated mitophagy

Sizhan Lin, Jingtao Liang, Jiafang Ye, Minping Chen et autres

African swine fever (ASF) is an acute, hemorrhagic, and highly contagious disease caused by African swine fever virus (ASFV), which causes severe economic losses in the swine industry. ASFV has evolved multiple strategies to evade host antiviral immune responses. Here, we report …

One-Click Egg Safety Check: A Syringe-Integrated Portable Platform for On-Site Fluoroquinolone Residue Detection

Yingying Feng, Wanqi Jiang, Wenya Liu, Yu Zhang et autres

A portable integrated sensing device incorporating a Tb 3+ /DTE-Cu NC ratiometric fluorescent probe was developed for the rapid on-site detection of fluoroquinolone (FQ) residues in poultry eggs. The system features a dual-layer filtration unit, consisting of glass wool and a polyvinyl …

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The deletion of the EP402R and MGF505/360 genes attenuates a genotype I/II recombinant ASFV but fails to confer complete protection against homologous or genotype II challenge in pigs

Yao Li, Yingnan Liu, Zhuyun Sun, Zhenhua Xie et autres

African swine fever (ASF), a pig disease caused by ASFV, is highly contagious and often lethal. The recent emergence of novel ASFV with I/II genomic recombination has posed significant challenges to global ASF prevention and control. In this study, we used the …

The deletion of the EP402R and MGF505/360 genes attenuates a genotype I/II recombinant ASFV but fails to confer complete protection against homologous or genotype II challenge in pigs

Yao Li, Yingnan Liu, Zhuyun Sun, Zhenhua Xie et autres

African swine fever (ASF), a pig disease caused by ASFV, is highly contagious and often lethal. The recent emergence of novel ASFV with I/II genomic recombination has posed significant challenges to global ASF prevention and control. In this study, we used the …

The deletion of the EP402R and MGF505/360 genes attenuates a genotype I/II recombinant ASFV but fails to confer complete protection against homologous or genotype II challenge in pigs

Yao Li, Yingnan Liu, Zhuyun Sun, Zhenhua Xie et autres

African swine fever (ASF), a pig disease caused by ASFV, is highly contagious and often lethal. The recent emergence of novel ASFV with I/II genomic recombination has posed significant challenges to global ASF prevention and control. In this study, we used the …

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E2-based mRNA vaccine encapsulated in lipid nanoparticles protects pigs against classical swine fever virus

Yingju Xia, Chuanwen Tian, Weiqiang Guo, Yingnan Liu et autres

ABSTRACT Classical swine fever (CSF), caused by the classical swine fever virus (CSFV), remains a significant threat to the global pig industry. Recent advances in mRNA vaccines offered a promising platform for combating CSFV. In this study, we designed and evaluated three …

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The Deletion of the EP402R and MGF505/360 Genes Attenuates a Genotype I/II Recombinant ASFV but Fails to Confer Complete Protection against Homologous or Genotype II Challenge in Pigs

Yao Li, Yingnan Liu, Zhuyun Sun, Zhenhua Xie et autres

African swine fever (ASF), a pig disease caused by ASFV, is highly contagious and often lethal. The recent emergence of novel ASFV with I/II genomic recombination has posed significant challenges to global ASF prevention and control. In this study, we used the …

Punicalagin Inhibits African Swine Fever Virus Replication by Targeting Early Viral Stages and Modulating Inflammatory Pathways

Renhao Geng, Dan Yin, Yingnan Liu, Hui Lv et autres

African swine fever (ASF), caused by the African swine fever virus (ASFV), has resulted in significant losses in the global pig industry. Considering the absence of effective vaccines, developing drugs against ASFV may be a crucial strategy for its prevention and control …

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Function investigation of p11.5 in ASFV infection

Dan Yin, Bin Shi, Renhao Geng, Yingnan Liu et autres

Virus replication relies on complex interactions between viral proteins. In the case of African swine fever virus (ASFV), only a few such interactions have been identified so far. In this study, we demonstrate that ASFV protein p72 interacts with p11.5 using co-immunoprecipitation …

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Giardia intestinalis extracellular vesicles induce changes in gene expression in human intestinal epithelial cells in vitro

Dongming Yang, Yingnan Liu, Yupeng Ren, Lili Hao et autres

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Immunogenicity and efficacy of an LNP-mRNA prepared from African swine fever virus K205R

Chuanwen Tian, Yingnan Liu, Dongdong Di, Zhenhua Xie et autres

African swine fever (ASF), caused by African swine fever virus (ASFV), is a highly contagious swine disease that has spread globally. Effective control strategies are not yet available. In this study, we prepared K205R mRNA, which was then formulated using Lipid Nanoparticle …

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