Yiying Zhu

A decision-driven framework for the mass spectrometry analysis of previously uncharacterized protein modifications

Yiying Zhu

Identification of unknown protein modifications remains challenging when the modification chemistry or site is not defined in advance. Conventional workflows often rely on predefined modification lists or enrichment strategies that assume prior knowledge of modification type and may therefore bias discovery toward …

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Pasteurized Akkermansia muciniphila alleviates high-fat diet-induced bone loss via Nr4a1-dependent Treg differentiation

Si Chen, Chenyang Zhang, Xue Liu, Yiying Zhu et autres

Background Obesity, a global epidemic, disrupts bone metabolism via gut microbiota dysbiosis, and probiotic/postbiotic supplementation emerges as a promising intervention. Akkermansia muciniphila (Akk), a next-generation probiotic, exerts metabolic benefits in obesity, yet its effects on bone homeostasis—especially in pasteurized form (pAkk)—and underlying …

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Fast and Site-Specific Covalent Targeting of Proteins by Arylfluorosulfate-Modified Aptamers

Kaining Zhang, Juan Li, Sining Hou, Zichen Qin et autres

Sulfur fluoride exchange (SuFEx) is a versatile click chemistry platform with emerging applications in covalent inhibitor development, among which arylfluorosulfate (AFS) derivatives have shown great promise because of their exclusive selectivity to target proteins. Nevertheless, due to the inherently mild electrophilicity of …

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Proteomics characterization of triple-negative apocrine carcinoma reveals molecular features of progression and chemotherapy response

Yiying Zhu, Mengping Long, Wenhao Shi, Tianlong He et autres

Triple-negative apocrine carcinoma (TNAC) is a rare and chemotherapy-insensitive subtype of triple-negative breast cancer (TNBC), characterized by specific morphology and molecular features. Despite limited chemotherapy response, TNAC shows favorable long-term survival, suggesting distinct resistance mechanisms. In this study, we present the first …

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Cathode-Localized Defects Structure: Enhancing Turn-Off Capability of IGCTs via Carrier Lifetime Engineering

Chunpin Ren, Yiying Zhu, Jiapeng Liu, Jianhong Pan et autres

Turn-off capability is a critical parameter of the Integrated Gate Commutated Thyristor (IGCT). To mitigate cathode retrigger failure, we propose a novel cathode-localized defects (CLD) structure. By introducing localized defects beneath the cathode, the CLD structure suppresses current density in this region …

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Integrated multi-dimensional comparison of proteomic profiles across 54 cancer cell lines

Wenhao Shi, Tianlong He, Nan Wang, Yuqiao Liu et autres

Human cancer cell lines are essential model systems in biomedical research. We conducted multi-level proteomics analyses on 54 widely used cancer cell lines derived from various tissues using two prominent proteomics technologies: mass spectrometry (MS) and reverse-phase protein array (RPPA). Our analysis …

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Optimized multiplex PCR-NGS for comprehensive HLA genotyping in Chinese populations: resolving ambiguities at high resolution

Cuello Garcia Haider, Binbin Sun, Yinfeng Wang, Zhoufan Zhang et autres

Introduction: Accurate human leukocyte antigen (HLA) genotyping is critical for organ transplantation to ensure donor-recipient compatibility. Conventional methods, such as sequence-based typing (SBT), often face challenges in resolving allelic ambiguities, particularly in highly polymorphic regions of HLA loci. Therefore, this study aimed …

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Development of CoCrNi-based alloys: Insights into elemental doping and additive manufacturing

Yiying Zhu, Huancai Li, Guijun Bi, Gui‐yong Xiao et autres

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The TikTok miracle: cracking the code of TikTok’s platform strategy

Yingkun Hou, Yiying Zhu

Purpose This study decodes the winning platform strategies behind TikTok's rapid rise in the social media ecosystem, aiming to provide generalizable insights for companies in the platform economy. It explores how TikTok overcame the formidable network effects of dominant platforms like Meta …

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Proteomic Landscape Uncovers Chemotherapy Resistance, Relapse Mechanisms, and Molecular Subtypes in Primary Central Nervous System Lymphoma for Precision Therapeutics

Yiying Zhu, Hao-Yi Li, Wenhao Shi, Yuan Qin et autres

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An Innovation Talent Cultivation Mechanism for Robotics in the Digital-Intelligent Era: Exploration and Practice at Wuhan University

Xiaohui Xiao, Yiying Zhu, Zhao Jun Guo, Yanzhao Ma et autres

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Microarc Oxidation Coatings Doped with a Low Proportion of Yttrium Enhance the Osseointegration of Titanium Implants through the BMP/Smad Pathway

Chenyang Zhang, Chenghui Qian, Guang Yang, Yiying Zhu et autres

High Resolution Image Download MS PowerPoint Slide Adding metal ions is a promising strategy to enhance the biological performance of titanium implants. In this study, we aimed to explore the effects of yttrium on the osseointegration of titanium implants. First, a series …

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