Zhaoran Wang

Celastrol’s covalent strike on HK2: Breaking a metabolic–epigenetic circuit to impede bladder cancer

Tong Shi, Chaoying Wen, Zhaoran Wang, Yi Jiao et autres

This study investigated how the natural compound celastrol (CEL) impedes bladder cancer (BLCA) progression by irreversibly occupying the ATP-binding pocket of hexokinase 2 (HK2). CEL binds directly to the ATP cleft of HK2, permanently inactivating its enzymatic function and consequently suppressing glycolytic …

cn, ca (code pays fourni par la source)

Dihydroartemisinin, a novel YTHDF2 inhibitor, alleviates rheumatoid arthritis by suppressing neutrophil extracellular traps via an autophagy-dependent pathway

Zhaoran Wang, Yi Jiao, Tong Shi, Chaoying Wen et autres

cn (code pays fourni par la source)

A New N6‐Methyladenosine Inhibitor, Celastrol, Alleviates Rheumatoid Arthritis via Targeting IGF2BP3

Qishun Geng, Yi Jiao, Wenya Diao, Jiahe Xu et autres

The proliferation of fibroblast-like synoviocytes (FLS) and macrophage-mediated inflammation are the main clinical features of rheumatoid arthritis (RA). Studies showed that insulin-like growth factor-2 mRNA binding protein-3 (IGF2BP3) may be involved in regulating the biological functions of different immune cells and FLS. …

cn (code pays fourni par la source)

Glabridin‐Gold(I) Complex as a Novel Immunomodulatory Agent Targeting TrxR and MAPK Pathways for Synergistic Enhancement of Antitumor Immunity

Zhaoran Wang, Meiyu Wang, Qiong Chen, Mengshi Wang et autres

Metal-based drugs have been utilized as immunomodulatory agents in combination with cancer immunotherapies to induce tumor immunogenicity. However, the immunosuppressive tumor microenvironment significantly hinders the efficacy of these immunomodulatory agents from promoting antitumor immune responses. Herein, a novel metal-based immunomodulatory agent, 6d, …

cn (code pays fourni par la source)

Islet Tissue Macrophages in Immunity Homeostasis and Type 1 Diabetes

Yan Wang, Zhaoran Wang, Wenya Diao, Tong Shi et autres

cn (code pays fourni par la source)

Targeted degradation of α-synuclein by arginine-based PROTACs

Linjing Shen, Jianchao Zhang, Zhaoran Wang, Yaxuan Liu et autres

Parkinson's disease (PD), the second most prevalent neurodegenerative disorder, is associated with α-synuclein (α-syn) overexpression or mutation, leading to harmful aggregates and neuronal apoptosis. Effective drugs that inhibit or reduce α-syn accumulation remain challenging. Targeted protein degradation (TPD) technology offers a novel …

cn, hk (code pays fourni par la source)

IGF2BP3-mediated m6A modification of RASGRF1 promoting joint injury in rheumatoid arthritis

Qishun Geng, Yi Jiao, Wenya Diao, Jiahe Xu et autres

Abstract With the deepening of epigenetic research, studies have shown that N 6 -methyladenosine (m 6 A) is closely related to the development of rheumatoid arthritis (RA), but the mechanism is still unclear. In the study, we collected synovial tissues from normal …

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Neutrophils: a Central Point of Interaction Between Immune Cells and Nonimmune Cells in Rheumatoid Arthritis

Zhaoran Wang, Yi Jiao, Wenya Diao, Tong Shi et autres

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Increased Alleviation of Bone Destruction in Individuals with Rheumatoid Arthritis via the Coinhibition of the METTL3 and YTHDF1 Axis by the Combination of Triptolide and Medicarpin

Yi Jiao, Zhaoran Wang, Wenya Diao, Qishun Geng et autres

Rheumatoid arthritis (RA) is a progressive autoimmune disease characterized by bone destruction that is primarily caused by the overactivation of osteoclasts (OCs), which are critical therapeutic targets. Triptolide (TP) has strong anti-RA effects but is limited by its narrow therapeutic window and …

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Cannabidiol regulates L-carnitine and butyric acid metabolism by modulating the gut microbiota to ameliorate collagen-induced arthritis

Qishun Geng, Zhaoran Wang, Tong Shi, Jiahe Xu et autres

cn (code pays fourni par la source)

Research progress of natural product-conjugated platinum and gold complexes as potential antitumor agents

Meiyu Wang, Fuwei Li, Zhaoran Wang, Lin Lv et autres

cn (code pays fourni par la source)

Key role for inflammation-related signaling in the pathogenesis of myopia based on evidence from proteomics analysis

Liqin Jiang, James H Z Koh, Sherlyn H Y Seah, Yee Shan Dan et autres

The mechanisms underlying myopia pathogenesis are not well understood. Using publicly-available human and animal datasets, we expound on the roles of known, implicated proteins, and new myopia-related signaling pathways were hypothesized. Proteins identified from human serum or ocular fluids, and from ocular …

sg, hk, us (code pays fourni par la source)