Yan Wang

Antibody-Oriented Engineering Enables Rapid and Ultrasensitive SERRS-Based Detection of Cardiac Troponin T for Acute Myocardial Infarction Diagnosis

Jun-Jie Wu, Shanshan Xu, Y. S. Lin, Gang Li et autres

Acute myocardial infarction (AMI) is a leading global cause of death with a sudden onset, which necessitates rapid and accurate diagnosis for effective treatment. However, existing detection methods for emergency scenarios (e.g., ambulances) suffer from limited sensitivity and high cost, hindering their …

cn, us (code pays fourni par la source)

Brain-derived exosomes from aged mice accelerate cognitive decline in repeated mild traumatic brain injury by activating neuronal Tnfrsf25

Y. N. Liu, Shan Liu, Bo Yan, Zhenyu Yin et autres

Aging increases vulnerability to cognitive decline after repetitive mild traumatic brain injury (rm-TBI), yet mechanisms linking age-related factors to neurodegeneration remain poorly understood. This study investigated how brain-derived exosomes from aged mice (A-Exo) worsen rm-TBI outcomes. In a murine rm-TBI model, intranasal …

cn (code pays fourni par la source)

Preclinical Development and Comparison of [ 99m Tc]Tc/[ 177 Lu]Lu-Labeled Anti-Trop2 Fc-Fused Nanobodies as Pancreatic Cancer Theranostics

Feng Yuan, Wenzhu Hu, Xingyi Wang, Yan Wang et autres

Antibody-based radiotheranostics hold significant promise for tumor diagnosis and treatment; however, the clinical translation of radiotherapeutic agents is significantly hindered by suboptimal pharmacokinetics, particularly undesirable retention in healthy tissues. In this study, we developed novel high-affinity anti-Trop2 nanobodies using phage display technology …

us, Malawi, cn, pl (code pays fourni par la source)

Improving uneven exposure using color characteristics as a priori information in endoscopic images

Yan Wang, Hao Wang, Xiaopan Xu, Kun Yang et autres

cn (code pays fourni par la source)

Propionic acid mediates the renoprotective effects of fecal microbiota transplantation against ischemia–reperfusion injury via upregulating GPR43

Jingxuan Yu, Zhenyu Liu, Yan Wang, Yu Zhou et autres

Introduction: Kidney ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI), characterized by aggravated inflammation and apoptosis following reperfusion. This study aimed to investigate the protective effects and mechanisms of fecal microbiota transplantation (FMT) in a rat model of …

cn, us, jp (code pays fourni par la source)

Dual-Functional Biomimetic Nanoprobes for PET Imaging-Guided Sonodynamic Therapy and Chemotherapy of Triple-Negative Breast Cancer

Wenzhu Hu, Xingyi Wang, Feng Yuan, Yan Wang et autres

Triple-negative breast cancer (TNBC), a highly aggressive subtype characterized by rapid invasion, metastatic propensity, and rising incidence, remains challenging due to the absence of targeted therapies. This study introduces a biomimetic nanoprobe coated with hybrid cell membranes (erythrocyte and tumor cell membranes) …

hk, cn, us, Malawi (code pays fourni par la source)

MRI-based radiomics predicts complete responses to initial transcatheter arterial chemoembolization in virus-associated early and intermediate stage HCC

Xinran Wen, Zhaoyang Xu, Hongbo Wang, Yan Wang et autres

cn (code pays fourni par la source)

Islet Tissue Macrophages in Immunity Homeostasis and Type 1 Diabetes

Yan Wang, Zhaoran Wang, Wenya Diao, Tong Shi et autres

cn (code pays fourni par la source)

Enhanced in vitro and in vivo antifungal efficacy against Candida albicans of nanostructured lipid carrier loaded with benzyl isothiocyanate extracted from Carica papaya L. seeds

Zelin Zheng, Zijie Li, Meng-Lin Yu, Xinyi Ma et autres

Candida albicans is the most prominent conditional fungal pathogen, which can cause systemic candidiasis when an individual becomes immunocompromised. The widespread and long-term use of azoles like fluconazole (FLC) has led to a significant increase in drug resistance, posing substantial challenges to …

cn (code pays fourni par la source)

UHEE-MAC: A Hybrid Emergency-Enabled MAC Protocol for the Internet of Underwater Things

Fei Ji, Yan Wang, Quansheng Guan, Fangjiong Chen et autres

Concerning the IoUT operating hybrid tasks, we introduce UHEE-MAC, an efficient MAC protocol that can enable quick emergency access as a sensor node switches from a non-emergency task to an emergency task and still supports a high throughput for non-emergency tasks. This …

cn (code pays fourni par la source)

Clinicopathological Features and Prognostic Implications of HER2-Low in Early-Stage Male Breast Cancer: A Retrospective Analysis

Qiang Sa, Hangcheng Xu, Yan Wang, Yiran Zhou et autres

cn (code pays fourni par la source)

Enhancement of Electron Transfer Between Fe/Mn Promotes Efficient Activation of Peroxomonosulfate by FeMn-NBC

Qiang Ge, Xianbo Zhou, Yan Wang, Congyun Zhu et autres

Bimetallic catalysts can effectively enhance the catalytic degradation efficiency of peroxymonosulfate (PMS), which is usually attributed to the enhancement of electron transfer, but currently, there is no clear explanation of the mechanism of how the electron transfer is enhanced. A nitrogen-doped Fe/Mn …

cn (code pays fourni par la source)