Liangren Liu

Toxicological Impacts and Mechanistic Insights of Bisphenol a on Clear Cell Renal Cell Carcinoma Progression: A Network Toxicology, Machine Learning and Molecular Docking Study

Jie Chen, Biao Ran, Bo Chen, Jingxing Bai et autres

Background: Clear cell renal cell carcinoma (ccRCC) is a prevalent urological malignancy, accounting for approximately 1.6% of all cancer-related deaths in 2022. While endocrine-disrupting chemicals (EDCs) have been implicated as risk factors for ccRCC, the toxicological profiles and immune mechanisms underlying Bisphenol …

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Identification of programmed cell death associated key genes in benign prostatic hyperplasia and prostate cancer development by integrated bioinformatics analysis and machine learning

Jie Chen, Bojie Chen, Ning Yin, Biao Ran et autres

Background: Up to now, the underlying molecular mechanisms of benign prostatic hyperplasia (BPH) and prostate cancer (PCa) remain unclear. This study aimed to identify programmed cell death (PCD) associated genes in BPH and PCa development by integrated bioinformatics analysis and machine learning …

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Toxicity and mechanistic analysis of di(2-ethylhexyl)phthalate in renal cell carcinoma progression: a systematic study with network toxicology and molecular docking strategies

Biao Ran, Xinyi Wang, Bohan Liu, Junjiang Ye et autres

Millions of tons of unrecycled plastic pollute landfills and oceans, and di(2-ethylhexyl) phthalate (DEHP), a plasticizer classified as a possible carcinogen, is found in many environments, and poses health risks. Renal cell carcinoma (RCC), one of the most prevalent malignancies, accounted for …

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Incidentally detected renal leiomyosarcoma with inferior vena cava tumor thrombus: a case report with review of the literature

Puze Wang, Jinze Li, Qian Liu, Dong Lv et autres

Kidney cancer is the 14th most common cancer worldwide. On the basis of the histological characteristics of kidney cancers, most kidney cancers are renal cell carcinomas. Renal leiomyosarcoma (LMS) is extremely rare and malignant and accounts for less than 1% of all …

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TNF-α modulates cell proliferation via SOX4/TGF-β/Smad signaling in benign prostatic hyperplasia

Jinze Li, Bo Chen, Yin Huang, Xinyang Liao et autres

Benign prostatic hyperplasia (BPH) is an age-related condition in men with a poorly defined etiology. Chronic inflammation is increasingly recognized as a key contributor to BPH progression; however, the underlying mechanisms remain incompletely understood. This study aimed to elucidate the role of …

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Toxicity and mechanistic analysis of Di(2- ethylhexyl)phthalate in renal cell carcinoma Progression: a systematic study with network toxicology and molecular docking strategies

Biao Ran, Xinyi Wang, Bohan Liu, Junjiang Ye et autres

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Mechanisms of DEHP in the prostate carcinogenesis: A comprehensive bioinformatics analysis

Biao Ran, Jie Chen, Dehong Cao, Liangren Liu

• Network toxicology revealed 115 targets, like BCL2 and CASP3, in DEHP-linked prostate cancer toxicity. • Enrichment analysis revealed the involvement of these genes in the prominent PI3K-AKT signaling pathway in prostate cancer. • Molecular docking demonstrated binding between DEHP and prostate …

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Incidence of major urological cancers in patients on dialysis: a systematic review and meta-analysis

Junjiang Ye, Biao Ran, Yin Huang, Zeyu Chen et autres

BACKGROUND: Studies have demonstrated an elevated risk of urological malignancies in individuals undergoing dialysis, which consequently leads to unfavorable prognoses and diminished quality of life for patients with end-stage kidney disease. Nevertheless, the absence of standardized recommendations for cancer screening and limited …

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Analysis of Toxicity and Mechanisms of Bisphenol Analogs in Male Infertility: Insights from Network Toxicology and Molecular Docking Approaches

Hao Ran, Liangren Liu

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Effect of tumor size on cancer-specific survival in small T1 renal cell carcinoma

Yige Jia, Junjiang Ye, Liangren Liu

• Renal cell carcinoma (RCC) is a common malignancy requiring early detection and accurate prognosis for optimal treatment. Using the SEER database, we investigated T1 RCC patients without distant metastasis who underwent radical nephrectomy (RN) or partial nephrectomy (PN) between 2004 and …

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Unlocking the Potential of ChatGPT in Male Sexual Health and Dysfunction: A Hold Endeavor and Comprehensive Study

Puze Wang, Liangren Liu

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The role of gut microbiota in prostate inflammation and benign prostatic hyperplasia and its therapeutic implications

Jie Chen, Bo Chen, Bin Lin, Yin Huang et autres

Background: The gut microbiota thrives in a complex ecological environment and its dynamic balance is closely related to host health. Recent studies have shown that the occurrence of various diseases including prostate inflammation is related to the dysregulation of the gut microbiome. …

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