Jie Chen

Prenatally elevated glucocorticoid disrupts social behavior via GR-Id3/E47-dependent astroglial dysfunction in LPS-induced autism-like rats

Binlin Yuan, Xueli Xiang, Ting Yang, Fang Lin et autres

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Identification of programmed cell death associated key genes in benign prostatic hyperplasia and prostate cancer development by integrated bioinformatics analysis and machine learning

Jie Chen, Bojie Chen, Ning Yin, Biao Ran et autres

Background: Up to now, the underlying molecular mechanisms of benign prostatic hyperplasia (BPH) and prostate cancer (PCa) remain unclear. This study aimed to identify programmed cell death (PCD) associated genes in BPH and PCa development by integrated bioinformatics analysis and machine learning …

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3202 – GRANULOCYTE COLONY-STIMULATING FACTOR VIA CSF3R-IFNG-ATM SIGNALING AXIS MEDIATES ALTERATIONS IN TCR REPERTOIRE AND T-CELL FUNCTION DURING DONOR HEMATOPOIETIC STEM CELL MOBILIZATION

Yangqiu Li, Xinye Li, Zhixi Chen, Xingwei Zhang et autres

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Disruption of the gut microbiota induces the LCA/TRPV6 signalling axis, impairing desmosome junctions in vitamin A-deficient rats

Junyan Yan, Yushuang Wang, Yuan Miao, Zhujun Sun et autres

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Corrigendum to “Increasing indoxyl sulfate induces iNOS expression via aryl hydrocarbon receptor leading to microglia hyperactivation in the prefrontal cortex of autism-like offspring rats” [Neurosci. Lett. 862 (2025) 138298]

Yuan Miao, Ruifang Luo, Fang Lin, Bei Tong et autres

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Increasing indoxyl sulfate induces iNOS expression via aryl hydrocarbon receptor leading to microglia hyperactivation in the prefrontal cortex of autism-like offspring rats

Yuan Miao, Ruifang Luo, Fang Lin, Bei Tong et autres

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TLR4 interaction with PIEZO1 facilitates the 5-HT-mediated intestinal motility dysfunction in offspring mice induced by LPS exposure during pregnancy

Ruifang Luo, Yuan Miao, Riqiang Hu, Lin Fang et autres

Several factors during pregnancy, such as changes in serotonin (5-HT) levels, can affect intestinal function in offspring mice. The role of 5-HT in regulating intestinal motility after lipopolysaccharide (LPS) exposure during pregnancy is unclear. In this study, Tlr4 fl/fl and Tlr4 △IEC …

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Lactobacillus reuteri or Lactobacillus rhamnosus GG intervention facilitates gut barrier function, decreases corticosterone and ameliorates social behavior in LPS-exposed offspring

Xinyuan Wang, Riqiang Hu, Fang Lin, Ting Yang et autres

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Serum Uric Acid Levels Associated with Outcomes of Neurodegenerative Disorders and Brain Health: Findings from the UK Biobank

Zihao Jiang, Jieyu Chen, Siqi Wu, Shuai Ji et autres

BACKGROUND: The relationship between serum uric acid (SUA) levels and brain-related health remains uncertain. OBJECTIVES: This study aimed to investigate the relationship between SUA levels and some neurodegenerative disorders and brain structure. DESIGN: A longitudinal study. SETTING AND PARTICIPANTS: 384,517 participants who …

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The mechanism of mitochondrial metabolic gene PMAIP1 involved in Alzheimer's disease process based on bioinformatics analysis and experimental validation

Yingchun Ling, Lingmin Hu, Jie Chen, Mingyong Zhao et autres

OBJECTIVES: This study explored novel biomarkers that can affect the diagnosis and treatment in Alzheimer's Disease (AD) related to mitochondrial metabolism. METHODS: The authors obtained the brain tissue datasets for AD from the Gene Expression Omnibus (GEO) and downloaded the mitochondrial metabolism-related …

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Preparation for postsecondary education of transition aged youth with intellectual disability and autism spectrum disorder in the United States: An Analysis of data from the national longitudinal transition study 2012

Meg Grigal, Clare Papay, Alberto Migliore, Belkis Choiseul‐Praslin et autres

Youth with intellectual disability and autism spectrum disorder increasingly access postsecondary education in many countries around the world. To ensure students are ready to access these options, preparation for postsecondary education must be part of their transition services. This study examines the …

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Roles of complement system in psychiatric disorders.

Yajie Huo, Jie Chen, Aomei Zhang, Cuilan Zhou et autres

The complement system is an important part of the innate immune system, including more than 50 secretory proteins and membrane-bound proteins, and it contributes to the clearance of apoptotic cells and invading pathogens to limit inflammatory immune responses and maintaining brain homeostasis. …

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