Lei Yu

Development of triazole-based positron emission tomography ligands targeting glutaminyl cyclases (QCs) in the brain

Wanqing Li, Xiaojun Zhang, Lei Yu, Donglan Huang et autres

cn (code pays fourni par la source)

Targeting QPCTL: An Emerging Therapeutic Opportunity

Lei Yu, Yaoliang Sun, Long-Yan Xie, Xiao Tan et autres

Glutaminyl cyclases, including glutaminyl-peptide cyclotransferase (QPCT) and glutaminyl-peptide cyclotransferase-like protein (QPCTL), primarily catalyze the cyclization of N-terminal glutamine or glutamate to pyroglutamate (pGlu). QPCTL, in particular, modifies the N-terminus of CD47, thereby regulating its interaction with signal-regulatory protein alpha (SIRPα) and modulating …

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Discovery of Pyrido[2,3-d]pyrimidin-7-one Derivatives as Highly Potent and Efficacious Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) Inhibitors for Cancer Treatment

Yaoliang Sun, Yuyan Han, Weiqiang Li, Xiaoyu Ma et autres

Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is an extracellular enzyme responsible for hydrolyzing cyclic guanosine monophosphate-adenosine monophosphate (cGAMP), the endogenous agonist for the stimulator of interferon genes (STING) pathway. Inhibition of ENPP1 can trigger STING and promote antitumor immunity, offering an attractive therapeutic target …

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Election Fraud and Protest Participation: Evidence from Belarus

Viktar Fedaseyeu, John G. Matsusaka, Lei Yu

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China-Russia Partnership and the Shanghai Cooperation Organization (SCO)

Lei Yu

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China-Russia Strategic Partnership and the Oil and Gas Collaboration

Lei Yu

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The Dynamics of Middle Powers and the Rise of China

Lei Yu

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Land for a Strategic Partnership?

Lei Yu

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China – Russia strategic partnership and the oil and gas collaboration

Lei Yu, Sophia X. Sui

Over the post-Cold War era, China has been committed to intensifying its strategic partnership with Russia in an attempt to usher into the world a new order. To achieve this goal, these two states have since the end of the Cold War …

cn, au (code pays fourni par la source)

Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein (QPCTL) with antitumor efficacy

Lei Yu, Pengcheng Zhao, Yaoliang Sun, Zening Zheng et autres

Immune checkpoint therapies manipulating the immune system to eliminate tumor cells have shown remarkable clinical efficacy in treating various cancers. CD47, an emerging efficient immune checkpoint, is crucial for cancer cells to evade macrophage-mediated phagocytosis by interaction with signal-regulatory protein α (SIRPα). …

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The Exact Boundary Controllability of Nodal Profile for Entropy Solutions to 1-D Quasilinear Hyperbolic Systems of Conservation Laws with Linearly Degenerate Negative (Resp., Positive) Characteristic Fields

Tatsien Li, Lei Yu

Abstract. We consider the exact boundary controllability of nodal profile for entropy solutions to 1-D quasilinear hyperbolic systems of conservation laws [Formula: see text] under the assumption that all negative (resp., positive) characteristic fields are linearly degenerate. We prove that for small …

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LLaMA-Reviewer: Advancing Code Review Automation with Large Language Models through Parameter-Efficient Fine-Tuning

Junyi Lu, Lei Yu, LI Xiao-jia, Yang Li et autres

The automation of code review activities, a long-standing pursuit in software engineering, has been primarily addressed by numerous domain-specific pre-trained models. Despite their success, these models frequently demand extensive resources for pre-training from scratch. In contrast, Large Language Models (LLMs) provide an …