Zhenyu Ding

Deulorlatinib (TGRX-326) in ALK Gene Fusion Positive NSCLC After Failure of Second-Generation Inhibitors: A Single-Arm, Multicenter, Phase 2 Trial

Jie Huang, Gang Chen, Zhehai Wang, Wenjian Jin et autres

INTRODUCTION: Deulorlatinib (TGRX-326), a potent third-generation anaplastic lymphoma kinase (ALK) inhibitor, has reported promising activity and a favorable safety profile in ALK-positive NSCLC in a phase 1 trial. Here, we report the primary results of the pivotal phase 2 trial (NCT05955391) evaluating …

cn, hk, us (code pays fourni par la source)

W2S-AlignTree: Weak-to-Strong Inference-Time Alignment for Large Language Models via Monte Carlo Tree Search

Zhenyu Ding, Yuhao Wang, T. Patrick Xiao, Haoying Wang et autres

Large Language Models (LLMs) demonstrate impressive capabilities, yet their outputs often suffer from misalignment with human preferences due to the inadequacy of weak supervision and a lack of fine-grained control. Training-time alignment methods like Reinforcement Learning from Human Feedback (RLHF) face prohibitive …

Integrated permanent-magnet-based quasi-zero stiffness low-frequency vibration isolator with nonlinear boundary constraints

Qiong Lin, Xiaoyan Wang, Zhengzheng Wang, Zhenyu Ding et autres

cn, us (code pays fourni par la source)

KK2DP7 Stimulates CD11b + Cell Populations in the Spleen to Elicit Trained Immunity for Anti‐Tumor Therapy

Rui Zhang, Lin Tang, Yusi Wang, Zhenyu Ding et autres

Abstract The induction of trained immunity for anti‐tumor therapy represents an emerging frontier in immunotherapy research, though its mechanistic underpinnings remain poorly understood. Adjuvant‐induced trained innate immune responses constitute a critical yet underexplored component of adjuvant mechanisms of action. Here, KK2DP7, a …

cn (code pays fourni par la source)

Design and performance investigation on a novel QZS metamaterial featuring concave hexagonal framework and double-cosine beams

Jun Zhu, Jiaming Hong, Chenyu Wang, Zhenyu Ding et autres

cn, us (code pays fourni par la source)

Sequential Autologous CIK/NK Cells Combined with Chemotherapy to Induce Long-Term Tumor Control in Advanced Rectal Cancer: A Case Report

Ji Yang, Zhenyu Ding, Yingyan Yu, Junde Liu et autres

Objective: Colorectal carcinoma (CRC) is the third most common malignancy. In addition to comprehensive cancer treatments, such as surgery, chemotherapy, and radiotherapy, the adoptive immune cell therapy (ACT) has played an increasingly important role in recent years, and the adaptive transfusion of …

cn (code pays fourni par la source)

Effects of postoperative treatment with chemotherapy and cellular immunotherapy on patients with colorectal cancer

Zhenyu Ding, Ying Piao, Tong Jiang, Juan Chen et autres

BACKGROUND The outcome of surgical treatment for colorectal cancer (CRC) remains unsatisfactory and warrants further exploration and optimization. AIM To clarify the impact of chemotherapy plus cellular immunotherapy [dendritic cell-cytokine-induced killer (DC-CIK) cell immunotherapy] on patients after CRC surgery and to explore …

cn (code pays fourni par la source)

Neoadjuvant Chemotherapy Combined with Camrelizumab for Resectable Locally Advanced Esophageal Squamous Cell Carcinoma: A Prospective Cohort Study

Yueyun Chen, Peipei Wang, Yang Hu, Yong Yuan et autres

cn (code pays fourni par la source)

Poor Efficacy of Immune Checkpoint Inhibitors Plus Chemotherapy in Lung Cancer Patients with EGFR/ERBB2 Exon 20 Insertion

Yue Zheng, Yang Fu, Yueyun Chen, Qing Li et autres

Background: EGFR and ERBB2 exon 20 insertion (Ex20ins) account for a small fraction of patients with EGFR mutations. The efficacy of immune checkpoint inhibitors (ICIs) for these patients was still controversial. Methods: This retrospective study enrolled lung cancer patients harboring either EGFR …

cn (code pays fourni par la source)

Longer interval between neoadjuvant chemoradiotherapy and surgery is associated with improved pathological response, but does not accurately estimate survival in patients with resectable esophageal cancer

Jiaqi Liu, Xiaoxiao Zeng, Xiaojuan Zhou, Yong Xu et autres

Neoadjuvant chemoradiotherapy (nCRT) has been shown to reduce tumor burden and achieve tumor regression in patients with esophageal cancer (ESC). However, the most beneficial time interval between the administration of nCRT and surgery remains unclear. Therefore, the aim of the present study …

cn (code pays fourni par la source)

Dramatic response to neoadjuvant savolitinib in marginally resectable lung adenocarcinoma with MET exon 14 skipping mutation: A case report and literature review

Jiangfang Tian, Zhen Lin, Yueyun Chen, Yang Fu et autres

Mesenchymal-epithelial transition (MET) exon 14 skipping mutation (METex14) is a low-frequency driver mutation in metastatic non-small cell lung cancer (NSCLC) (3%-4%) and is associated with a poor prognosis. With the advent of selective MET inhibitors such as capmatinib, tepotinib, and savolitinib, the …

cn (code pays fourni par la source)

Identification pyroptosis-related gene signature to predict prognosis and associated regulation axis in colon cancer

Kexun Zhou, Xuyu Gu, Huaicheng Tan, Ting Yu et autres

Background: Pyroptosis is an important component of the tumor microenvironment and associated with the occurrence and progression of cancer. As the expression of pyroptosis-related genes and its impact on the prognosis of colon cancer (CC) remains unclear, we constructed and validated a …

cn (code pays fourni par la source)