Jie Huang

Deulorlatinib (TGRX-326) in ALK Gene Fusion Positive NSCLC After Failure of Second-Generation Inhibitors: A Single-Arm, Multicenter, Phase 2 Trial

Jie Huang, Gang Chen, Zhehai Wang, Wenjian Jin et autres

INTRODUCTION: Deulorlatinib (TGRX-326), a potent third-generation anaplastic lymphoma kinase (ALK) inhibitor, has reported promising activity and a favorable safety profile in ALK-positive NSCLC in a phase 1 trial. Here, we report the primary results of the pivotal phase 2 trial (NCT05955391) evaluating …

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IR-Flow: Bridging Discriminative and Generative Image Restoration via Rectified Flow

Zihao Fan, Xin Lu, Jie Xiao, Dong Li et autres

In image restoration, single-step discriminative mappings often lack fine details via expectation learning, whereas generative paradigms suffer from inefficient multi-step sampling and noise-residual coupling. To address this dilemma, we propose IR-Flow, a novel image restoration method based on Rectified Flow that serves …

NEXN targeting MYOCD by facilitating EMT-related β-catenin nuclear translocation modulates the metastasis of hepatocellular carcinoma

Qiong Wu, Xue Liu, Ying Xu, Hui Wu et autres

. NEXN overexpression downregulated the expression of mesenchymal markers and partially upregulated E-cadherin expression. Mechanistically, NEXN overexpression reduced β-catenin nuclear accumulation. Furthermore, by binding to MYOCD, NEXN co-regulated the EMT in HCC through the WNT/β-catenin signaling pathway. In conclusion, the diminished expression …

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Quantitative MRI Evaluation of the Effects of Rest and Different Intensities of Running on the Recovery of Thigh Muscle Microdamage After a Half Marathon

Jing Zhou, Cheng‐Yuan Xu, Yawen Wu, Xingyu Mao et autres

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Obesity metabolomics signature in children: associations with metabolic abnormalities and potential biomarkers

Jiayi Wan, Shiyun Luo, Wanzhen Zhong, Jiaying Guo et autres

Background: The global rise in childhood obesity has heightened its recognition as a major public health concern, with obesity being an independent risk factor for metabolic abnormalities. However, the metabolomics mechanisms linking pediatric obesity to metabolic abnormalities remain unclear. Methods: This case-control …

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Age-related incidence of mismatch repair deficiency (dMMR) and its prognostic role in BRAF-mutant colorectal cancer

Weiyu Pan, Minying Deng, Chen Xu, Lijuan Luan et autres

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Prognostic value of diffusion-weighted imaging to cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy for patients with gastric cancer and peritoneal metastases

Xin Xin, Yongfang Tang, Man Lu, Jie Huang et autres

To investigate the prognostic value of the apparent diffusion coefficient (ADC) calculated from diffusion-weighted imaging (DWI) to cytoreductive surgery (CRS), with or without hyperthermic intraperitoneal chemotherapy (HIPEC), for gastric cancer (GC) patients with peritoneal metastasis (PM). Between May 2016 and December 2020, …

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An interpretable machine learning model based on computed tomography radiomics for predicting programmed death ligand 1 expression status in gastric cancer

Jinxue Yin, Xin Xin, Chun Yao, Yongfang Tang et autres

BACKGROUND: Programmed death ligand 1 (PD-L1) expression status, closely related to immunotherapy outcomes, is a reliable biomarker for screening patients who may benefit from immunotherapy. Here, we developed and validated an interpretable machine learning (ML) model based on contrast-enhanced computed tomography (CECT) …

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Prediction of immunotherapy response in nasopharyngeal carcinoma: a comparative study using MRI-based radiomics signature and programmed cell death ligand 1 expression score

Hui Mai, L Li, Xin Xin, Yongfang Tang et autres

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Identification of Significant Single‐Nucleotide Polymorphisms Associated With Breast Cancer Recurrence and Metastasis Using GWAS

Shujuan Sun, Sha Yin, Jie Huang, Dong‐Dong Zhou et autres

Background: Identification of risk genes and loci associated with the recurrence and metastasis of breast cancer (BC) is of utmost importance. Genome-wide association studies (GWASs) represent valuable tools for identifying the disease risk associated with a given single-nucleotide polymorphism (SNP); they offer …

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Advances in immuno-based and targeted therapies in extensive-stage small cell lung cancer

Jie Huang, Hao Sun, Lina Chen, Xiu-Hao Zhang et autres

Immunotherapy now plays a key role in supplementing and even replacing conventional agents in tumor treatment. Immune checkpoint inhibitors (ICIs), represented by atezolizumab and durvalumab, have shown encouraging therapeutic effects in the combination chemotherapy for extensive-stage small cell lung cancer (SCLC) and …

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Endothelin-1 Mediates Oxaliplatin Resistance via Activation of YAP Signaling in Colorectal Cancer

Ranran Yang, Dan Yuan, Siying Zhu, Jie Huang et autres

Background: Colorectal cancer (CRC) is a predominant contributor to global cancer-associated mortality worldwide. Oxaliplatin (OXP), a foundational chemotherapeutic agent for CRC, often exhibits limited efficacy due to the emergence of drug resistance. Although endothelin-1 (EDN1) has been implicated in tumor drug resistance, …

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