Jeong-Jae Lee

Abstract 4589: Synergistic effects of EZH1/2 dual inhibition and cisplatin on lung cancer cell lines with loss of SMARCA4 and SMARCA2

Jeong-Jae Lee, Bhumsuk Keam, Soyeon Kim, Jeonghwan Youk et autres

Abstract Purpose: SMARCA4 mutations are observed in approximately 10% of non-small cell lung cancer (NSCLC) cases and are implicated in various biological functions. Lung cancers harboring these mutations are associated with poor prognosis and often exhibit resistance to conventional chemotherapies, highlighting the …

kr (code pays fourni par la source)

Fast and accurate protein structure search with Foldseek

Michel van Kempen, Stephanie Kim, Charlotte Tumescheit, Milot Mirdita et autres

As structure prediction methods are generating millions of publicly available protein structures, searching these databases is becoming a bottleneck. Foldseek aligns the structure of a query protein against a database by describing tertiary amino acid interactions within proteins as sequences over a …

de, kr, pr, am (code pays fourni par la source)

Monalizumab efficacy correlates with HLA-E surface expression and NK cell activity in head and neck squamous carcinoma cell lines

Jeong-Jae Lee, Bhumsuk Keam, Ha-Ram Park, Ji Eun Park et autres

kr, us (code pays fourni par la source)

The antitumor activity of a novel GCN2 inhibitor in head and neck squamous cell carcinoma cell lines

Jeong-Jae Lee, Bhumsuk Keam, Soyeon Kim, Jung‐Nyoung Heo et autres

BACKGROUND: General control nonderepressible 2 (GCN2) senses amino acid deprivation and activates activating transcription factor 4 (ATF4), which regulates many adaptive genes. We evaluated the impact of AST-0513, a novel GCN2 inhibitor, on the GCN2-ATF4 pathway. Additionally, we evaluated the antitumor effects …

kr, us, Éthiopie (code pays fourni par la source)

Monalizumab efficacy correlates with HLA-E surface expression and NK cell activity in head and neck squamous carcinoma cell lines

Jeong-Jae Lee, Bhumsuk Keam, Ha-Ram Park, Ji Eun Park et autres

Abstract Purpose NKG2A, an inhibitory receptor expressed on NK cells and T cells, leads to immune evasion by binding to HLA-E expressed on cancer cells. Here, we investigated the relationship between HLA-E surface expression on head and neck squamous cell carcinoma (HNSCC) …

kr, Éthiopie, pr (code pays fourni par la source)

Fast and accurate protein structure search with Foldseek

Michel van Kempen, Stephanie Kim, Charlotte Tumescheit, Milot Mirdita et autres

As structure prediction methods are generating millions of publicly available protein structures, searching these databases is becoming a bottleneck. Foldseek aligns the structure of a query protein against a database by describing the amino acid backbone of proteins as sequences over a …

de, kr (code pays fourni par la source)

Development of RESTful Web Service for Loading Data focusing on Daily Meteorological Data

Tae‐Gon Kim, Jeong-Jae Lee, Won‐Ho Nam, Kyo Suh

Generally data loading is a laborous job to develop models. Meteorological data is basic input data for hydrological models, it is provided through websites of Korea Meteorological Administration (KMA). The website of KMA provides daily meteorological observation data with tabular format classified …

Preparation of anti-fouling acetylated mecellose ultrafiltration hollow fiber membrane

Young‐Nam Kwon, Doo-Hyun Song, Hye-Jin Lee, Han-Na Jang et autres

Estimating Employment‐Related Migration from Overlapping Migration and Commuting Networks

Yicheol Han, Stephan J. Goetz, Tae‐Gon Kim, Jeong-Jae Lee

Abstract A U.S. county workplace‐to‐workplace or latent migration data set is generated from overlapping migration and commuting networks. The latent migration network is the estimated number of movers between places of work, which is then compared with the actual number of migrants …

kr, us (code pays fourni par la source)

Quantitative Effect Evaluation and Spatial Autocorrelation Analysis of Rural Development Projects

Jimin Lee, Yeonjoung Bae, Tae‐Gon Kim, Jeong-Jae Lee et autres

A lot of rural development projects have been planned and implemented for revitalizing rural areas in South Korea. However, it is not easy to properly evaluate and quantitatively analyze project outcomes. For this reason only selected regions have been evaluated for rural …

kr (code pays fourni par la source)

농촌개발사업 효과의 정량적 평가 및 공간적 연관 분석

Jimin Lee, 배연정, Tae‐Gon Kim, Jeong-Jae Lee et autres

A lot of rural development projects have been planned and implemented for revitalizing rural areas in South Korea. However, it is not easy to properly evaluate and quantitatively analyze project outcomes. For this reason only selected regions have been evaluated for rural …

Analysis on Characteristics of Time Allotments for Activities of Rural Elder Population

Yoon‐Hee Lee, Yeonjoung Bae, Jimin Lee, Jeong-Jae Lee et autres

The time management and allotments for various activities of daily life is much different by age groups. This study analyzes time allotments of different age groups for various activities of daily life to figure out the change of main activity by aging …

kr (code pays fourni par la source)