Ashish Mishra

RelB NF-κB tunes Notch2 signaling to promote IL-23-secreting solitary isolated lymphoid tissue–resident DCs critical for gut immunity

Naveen Kumar, Alvina Deka, Swapnava Basu, Ashish Mishra et autres

While preserving tolerance toward commensals, dendritic cells (DCs) also orchestrate response against pathogens. The noncanonical RelB NF-κB pathway in DCs curbs tolerogenic Tregs in the intestine. Whether RelB-dependent DC regulations also impact intestinal immunity remains less clear. Here, we show that genetic …

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Prospective Analysis of Uroflowmetric Changes after Transurethral Resection of the Prostate (TURP)

Manish Acharya, Ijan Dhamala, Soniya Bhatta, Kuldip Sapkota et autres

Introduction: Benign Prostatic Hyperplasia (BPH) is a common condition in aging men, often causing Lower Urinary Tract Symptoms (LUTS) that negatively impact quality of life. Transurethral Resection of the Prostate (TURP) is the gold-standard surgical treatment for patients who fail medical therapy. …

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An intranasal adjuvanted, recombinant influenza A/H5 vaccine primes against diverse H5N1 clades: a phase I trial

Meagan E. Deming, Franklin R. Toapanta, Marcela F. Pasetti, Hana Golding et autres

Abstract Mucosal influenza vaccines may provide improved protection against infection and transmission, but their development is hindered by absence of immune correlates of protection. Here, we report a randomized, controlled phase I trial of a recombinant influenza A/H5 (A/Indonesia/05/2005, clade 2.1) hemagglutinin …

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A comparative study of surgical site infections in clean elective surgical procedures with and without antibiotic prophylaxis

Ashish Mishra, Vijay Chetan Jha

Background: Surgical site infections (SSI) are the primary (40%) cause of nosocomial infection in surgical patients. Surgical antibiotic prophylaxis (SAP) is the use of antibiotics to prevent infections at the surgical site. However, in clean surgical wound inappropriate antibiotic prophylaxis such as …

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Elective Laparoscopic Cholecystectomy: A Clean Surgery

Ashish Mishra, Priya Ranjan, Vijay Chetan Jha, Vikram Trehan

Abstract Background: Laparoscopic cholecystectomy (LC) has become the gold standard procedure for treatment of cholelithiasis. It has many advantages over open cholecystectomy in terms of small incision, minimal postoperative pain, shorter hospital stays, better cosmesis and early recovery. The incidence of infectious …

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From Habit to Hazard: Areca Nut Consumption Leading to Gastric Outlet Obstruction

Ijan Dhamala, Ashish Mishra, Mukul Kulshrestha, Afsar Ali et autres

Bezoars are uncommon masses formed in the gastrointestinal tract, often categorized into pharmacobezoars, lactobezoars, trichobezoars, lithobezoars, and phytobezoars based on their composition. This report details a rare case of a 23-year-old male presenting with recurrent vomiting, abdominal pain, and a palpable lump …

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Gallbladder Carcinoma: A Review of Literature

Mukul Kulshrestha, Ashish Mishra, Yogapriya Velumani

Gallbladder cancer (GBC) is the most common cancer of the biliary tract but the sixth most common cancer of the gastrointestinal tract. This tumor has a very high death rate. It is impossible to emphasize how crucial early diagnosis is because GBC …

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Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus

Surender Khurana, Lisa R. King, Jody Manischewitz, Olivia Posadas et autres

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In vitro enhancement of Zika virus infection by preexisting West Nile virus antibodies in human plasma-derived immunoglobulins revealed after P2 binding site-specific enrichment

Yong He, Lilin Zhong, Hailing Yan, Maria Luisa Virata et autres

ABSTRACT Human immunoglobulin preparations contain a diverse range of polyclonal antibodies that reflect past immune responses against pathogens encountered by the blood donor population. In this study, we examined a panel of intravenous immunoglobulins (IGIVs) manufactured over the past two decades (1998–2020) …

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Effect of ankle versus thigh tourniquets on post-operative pain in foot and ankle surgery

Ashish Mishra, Ahmed Barakat, Jitendra Mangwani, J Kazda et autres

BACKGROUND Tourniquets are commonly used in elective extremity orthopaedic surgery to reduce blood loss, improve visualization in the surgical field, and to potentially reduce surgical time. There is a lack of consensus in existing guidelines regarding the optimal tourniquet pressure, placement site, …

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Do Baseline Scores or Comorbidities Affect Patient-reported Outcome Measures Following First Metatarsophalangeal Joint Arthrodesis?

Jitendra Mangwani, Linzy Houchen‐Wolloff, Vidhi Adukia, Ashish Mishra et autres

reliability.11,12 When patients fail a trial of conservative management, options such as footwear modifications (wide-toe box shoes and offloading orthotics), anti-inflammatories, and intraarticular steroid IntroductIonOsteoarthritis (OA) of the first metatarsophalangeal joint (MTPJ), also known as hallux rigidus (HR), is the most common …

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Effect of Body Mass Index on the outcomes of primary Total Knee Arthroplasty up to one year – A prospective study

Ashish Mishra, Abhishek Vaish, Raju Vaishya

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