Prospective Analysis of Uroflowmetric Changes after Transurethral Resection of the Prostate (TURP)

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Introduction: Benign Prostatic Hyperplasia (BPH) is a common condition in aging men, often causing Lower Urinary Tract Symptoms (LUTS) that negatively impact quality of life. Transurethral Resection of the Prostate (TURP) is the gold-standard surgical treatment for patients who fail medical therapy. This study aimed to assess changes in uroflowmetric parameters and correlate them with symptomatic improvement following TURP. Methods: This hospital-based, prospective, observational study included 80 male patients over 50 years with LUTS due to BPH, who underwent TURP at a tertiary care center in Pokhara, Nepal, between September 2022 and January 2024. Objective parameters, including Maximum Flow Rate (Qmax) and Average Flow Rate (Qaverage), and subjective parameters, comprising International Prostate Symptom Score (IPSS), Quality of Life (QoL), and Post-Void Residual Urine (PVRU), were assessed preoperatively and at one and three months postoperatively. Data were analyzed using repeated measures Analysis of Variance (ANOVA), with p < 0.05 considered statistically significant. Results: The mean age of participants was 69.81 ± 8.25 years. Preoperative Qmax (11.51 ± 2.73 mL/sec) improved to 16.89 ± 3.12 mL/sec at one month and 16.91 ± 2.71 mL/sec at three months (p < 0.05). Qaverage increased from 6.93 ± 1.99 mL/sec preoperatively to 10.44 ± 1.99 mL/sec and 11.01 ± 2.05 mL/sec postoperatively (p < 0.05). Significant improvements were also observed in IPSS, QoL, and PVRU. Conclusion: TURP significantly improves both objective (Qmax, Qaverage) and subjective (IPSS, QoL) outcomes in patients with BPH. Uroflowmetry is a simple, noninvasive, and reliable tool for evaluating functional recovery after TURP.

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