Lin Chen

Letter regarding the article ‘Clinical profiles and prognostic impact of residual intravascular and tissue congestion in acute heart failure’

Xinyan Qi, Jianbao WANG, Lin Chen

We read with great interest the article by Ceelen et al.1 investigating the clinical profiles and prognostic impact of residual intravascular and tissue congestion in acute decompensated heart failure (ADHF). This post hoc analysis of the PROTECT and RELAX-AHF-2 trials provides valuable …

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The relationship between digital literacy and mental health resilience among college students—based on the mediating role of digital learning

Xiaodong Li, Junting Su, Jiaxin Mao, Lin Chen et autres

Background: In the context of educational digital transformation, digital literacy is increasingly recognized as a key psychological resource beyond technical skills. However, the specific mechanisms and group differences through which it influences college students' psychological resilience remain underexplored. This study examines how …

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OsCDPK24 and OsCDPK28 phosphorylate heat shock factor OsHSFA4d to orchestrate abiotic and biotic stress responses in rice

Haicheng Liao, Yingjie Wei, Junjie Yin, Xiaoqian Liu et autres

Global warming impacts crop production and increases crop disease. It is commonly known that heat stress (HS) caused by extreme high temperature induces HS responses but suppresses disease resistance in plants. However, the molecular basis of this trade-off remains largely unknown. Here, …

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IGF2BP1 promotes the progression of head and neck squamous cell carcinoma by activating PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition

Guohua Hu, Yanshi Li, Tao Lü, Min Pan et autres

BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most prevalent cancer globally, with lymph node metastasis being a primary contributor to poor patient prognosis. Elucidating the molecular mechanisms driving HNSCC lymphatic metastasis is imperative for developing targeted therapeutic …

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A tumor microenvironment-responsive nanocomposite for enhanced copper retention and hypoxia reversal to promote cuproptosis in tumor treatment

Wei Chen, Lin Chen, Zhimin Gao, Yongxin Huang et autres

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Analysis of sedative-hypnotic drug use trends in children and adolescents (2018–2023): a study based on outpatient prescription data from a general hospital

Le Ma, Hou Yanbin, Pingping Miao, Lin Chen et autres

Objective This study aims to analyze the use of sedative-hypnotic drugs among children and adolescents in a hospital setting, providing a reference for optimizing drug use. Methods A retrospective analysis was conducted on the prescription data of sedative-hypnotic drugs for children and …

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Fully Biobased Copolyesters with High Gas Barrier and Enhanced Mechanical Properties Derived from 2,5-Thiophenedicarboxylic Acid and Long-Chain Dicarboxylic Acid

Jiyang Zuo, Tao Yang, Lin Chen, Hongxia Deng et autres

This work provides an in-depth molecular structure design strategy for developing high-barrier polymer packaging films. A series of high-performance PPDThF copolyesters were prepared by utilizing the unique crystallization ability of poly(propylene 2,5-thiophenedicarboxylate) (PPThF), as well as a long-chain dicarboxylic acid, namely dodecanedioic …

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Rice transcription factor bHLH25 confers resistance to multiple diseases by sensing H2O2

Haicheng Liao, Yu Fang, Junjie Yin, Min He et autres

Abstract Hydrogen peroxide (H 2 O 2 ) is a ubiquitous signal regulating many biological processes, including innate immunity, in all eukaryotes. However, it remains largely unknown that how transcription factors directly sense H 2 O 2 in eukaryotes. Here, we report …

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Emodin induced hepatic steatosis in BALb/c mice by modulating the gut microbiota composition and fatty acid metabolism

Xinhua Xia, Xueling He, Jinzhou Huang, Lin Chen et autres

Introduction The aim of this study is to examine the physiological effects of emodin on intestinal microorganisms and the liver in the BALb/c mice. Method and Results Following an 8-week administration of emodin at doses of 25, 50, and 100 mg/kg/day,pathological analyses …

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Temporal, spatial and demographic distributions characteristics of COVID-19 symptom clusters from chinese medicine perspective: a systematic cross-sectional study in China from 2019 to 2023

Bin Liu, Mingzhi Hu, Zhaoyuan Gong, Qianzi Che et autres

BACKGROUND: The subtypes diagnosis of disease symptom clusters, grounded in the theory of "Treatment in Accordance with Three Categories of Etiologic Factors" and International Classification of Diseases 11th Revision (ICD-11), is a vital strategy for Chinese Medicine (CM) in treating unknown respiratory …

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TNFRSF18+ Tregs Impair Immunotherapy Efficacy in Immunosuppressed Colon Cancer Patients

Kangfu Dai, Songbin Lin, Jianping Wang, Lin Chen et autres

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Cell Cycle-Related LncRNA-Based Prognostic Model for Hepatocellular Carcinoma: Integrating Immune Microenvironment and Treatment Response

Lin Chen, Guozhi Wu, Tao Wu, Hao-Hu Shang et autres

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