Liting Lu

The Hcp2b protein of APEC induces defective autophagy in HD11 cells by causing lysosomal dysfunction

Yaqin Tian, Liting Lu, Shuhui Wang, Jingwen Zhang et autres

RESEARCH HIGHLIGHTS: APEC Hcp2b protein translocates into HD11 cells and induces significant cytotoxicity.Hcp2b elicits incomplete autophagy, characterized by blocked autophagic flux.Proteomic analysis demonstrated Hcp2b impairs lysosomes, blocking autophagy.

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NLRC3 suppresses hepatocarcinogenesis by disrupting the HSP90-mediated TRAF6/MYC signalling activation

Shishun Huang, Chen Zheng, Zheng Zhang, Juji Dai et autres

NLRC3 serves as a critical negative regulator of inflammatory signalling pathways and is implicated in the pathogenesis of multiple disorders, including inflammatory diseases and malignancies. However, the specific functions and underlying mechanisms of NLRC3 in hepatocellular carcinoma (HCC) development remain largely elusive. …

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Distinct Germline Mutation Landscape and Clinical Implications in Chinese Colorectal Cancer: A Large‐Scale Genomic Analysis of 1094 Patients

Liting Lu, Xinyu Peng, J H Zhang, Yixin Ding et autres

OBJECTIVE: To investigate the prevalence, characteristics, and clinical implications of germline mutations in a consecutive cohort of Chinese colorectal cancer (CRC) patients, providing insights that may inform population-specific genetic testing strategies. METHODS: A total of 1094 CRC patients from two centers were …

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Avian pathogenic Escherichia coli virulence protein Hcp2a induces incomplete autophagy in chicken HD11 cells

Yaqin Tian, Yuqi Zhang, Liting Lu, Shuhui Wang et autres

The hemolysin co-regulator protein (Hcp) is a core virulence protein of the Type VI Secretion System (T6SS) in avian pathogenic Escherichia coli (APEC) and plays a critical role in host-pathogen interactions. While several bacterial effectors are known to subvert host immunity by …

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RSPO1-LGR4 axis drives cervical cancer progression via activation of the EGFR/Src/ERK/AKT signaling pathway

Xincheng Lu, Liting Lu, Xiduan Wei, Sai Liu et autres

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Nicotinamide produced by Bifidobacterium longum A127 ameliorates heat stress-induced brain damage by inhibiting the p38 MAPK pathway

Haiyang Tu, Kai Zhang, Siyuan Shen, Liting Lu et autres

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Parkinson's Disease and Cancer: Mechanistic Insights and Therapeutic Opportunities From Cancer Neuroscience

Tianli Pan, Lin Yuan, Ruoyang Zhao, Liting Lu et autres

ABSTRACT There is a complex pathological association between neurodegenerative diseases and cancer. The epidemiological negative correlation between Parkinson's disease (PD) and brain tumor is particularly noteworthy. PD is characterized by the loss of dopaminergic neurons and the formation of Lewy bodies, while …

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Calenduloside E from B. animalis B960 enhances glibenclamide efficacy and alleviates drug-induced side effects via the IRS1/PI3K/AKT pathway in T2D

Jiachao Zhang, Siyuan Shen, Liting Lu, Haiyang Tu et autres

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Establishment of Interspecies Somatic Cell Nuclear Transfer and Transgene‐Free Inducible Pluripotent Stem Cells for Versatile Conservation of the Germplasm Resource of Wild Boar

Gao Chen, Xinyi Zhou, S. Gu, Jianbo Li et autres

ABSTRACT Cloning via somatic cell nuclear transfer and establishing inducible pluripotent stem cells is critical for the conservation of the cherished germplasm resource. The wild boar population would be altered due to human activities and climate change. Recently, we have successfully generated …

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Rapid and visual detection of transmissible gastroenteritis virus using a CRISPR/Cas12a system combined with loop-mediated isothermal amplification

Haiyang Wang, Qi Dong Zhao, Jiale Wang, Zhenjie He et autres

Transmissible gastroenteritis (TGE) is a highly contagious intestinal disease caused by transmissible gastroenteritis virus (TGEV). The primary techniques for identifying TGEV involve enzyme-linked immunosorbent assay (ELISA), polymerase chain reaction (PCR), and fluorescent quantitative PCR (qPCR). However, these approaches are complex, demanding specialized …

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RETRACTED: Molecular characteristics of oligomeric protein complexes AIM2 and TM4SF19 and their association with the pathogenesis of oral squamous cell carcinoma: Potential biomarkers

Jinlan Lu, Ming Deng, Liting Lu, Jiaojiao Li et autres

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The PDE4DIP-AKAP9 axis promotes lung cancer growth through modulation of PKA signalling

Yangyang Fu, Shishun Huang, Rulu Pan, X. Chen et autres

Phosphodiesterase 4D interacting protein (PDE4DIP) is a Golgi/centrosome-associated protein that plays critical roles in the regulation of microtubule dynamics and maintenance of the Golgi structure. However, its biological role in human cancer remains largely unknown. In this study, we showed that PDE4DIP …

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