Thomas J. Hopkins

Apolipoprotein E Mimetic Peptide CN-105 and Postoperative Delirium in Older Patients

Noah J. Timko, Mary Cooter Wright, Melody R. Smith, Piper C. Boykin et autres

Importance: The apolipoprotein E (APOE) gene ε4 allele leads to increased Alzheimer disease risk and neuroinflammation and is also believed to play a role in postoperative delirium. However, the safety and feasibility of modulating apoE protein signaling to reduce postoperative neuroinflammation and …

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Radiofrequency Ablation Provides Rapid and Durable Pain Relief for the Palliative Treatment of Lytic Bone Metastases Independent of Radiation Therapy: Final Results from the OsteoCool Tumor Ablation Post-Market Study

Jason R. Levy, Elizabeth David, Thomas J. Hopkins, Jonathan M. Morris et autres

PURPOSE: The OsteoCool Tumor Ablation Post-Market Study (OPuS One) was a prospective, multi-national, single-arm study to investigate safety and effectiveness of radiofrequency ablation (RFA) for palliation of painful lytic bone metastases with 12 months of follow-up. RFA has demonstrated effective palliation of …

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Durable patient-reported outcomes following 60-day percutaneous peripheral nerve stimulation (PNS) of the medial branch nerves

Christopher A Gilmore, Timothy Ray Deer, Mehul J. Desai, Thomas J. Hopkins et autres

Background: Chronic low back pain (CLBP) is often associated with clinical evidence of central nervous system sensitization and finding a clear source of nociceptive input can be challenging. Conventional therapies targeting peripheral spinal pain structures can fail to address centrally-mediated, underlying causes …

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Height restoration and sustainability using bilateral vertebral augmentation systems for vertebral compression fractures: a cadaveric study

Derek T. Holyoak, Thomas G. Andreshak, Thomas J. Hopkins, Allan Brook et autres

BACKGROUND CONTEXT: The treatment of vertebral compression fractures using percutaneous augmentation is an effective method to reduce pain and decrease mortality rates. Surgical methods include vertebroplasty, kyphoplasty, and vertebral augmentation with implants. A previous study suggested that a titanium implantable vertebral augmentation …

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Treatment of chronic axial back pain with 60‐day percutaneous medial branch PNS: Primary end point results from a prospective, multicenter study

Christopher A Gilmore, Mehul J. Desai, Thomas J. Hopkins, Sean Li et autres

BACKGROUND: The objective of this prospective, multicenter study is to characterize responses to percutaneous medial branch peripheral nerve stimulation (PNS) to determine if results from earlier, smaller single-center studies and reports were generalizable when performed at a larger number and wider variety …

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Radiofrequency ablation for palliative treatment of osseous metastases results in rapid, significant, and durable improvements in pain relief and quality of life: Results from the OPuS One trial.

Jason R. Levy, Elizabeth David, Thomas J. Hopkins, Jonathan M. Morris et autres

12086 Background: Patients with bone metastases may experience pain and decreased quality of life. Standard of care therapies such as radiation therapy could take weeks for pain relief and carry a risk of radiation induced fracture. Minimally invasive percutaneous radiofrequency ablation (RFA) …

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Abstract No. 2 ▪ ABSTRACT OF THE YEAR Radiofrequency ablation for the palliative treatment of osseous metastases: final results from a multicenter study (OPuS One)

Jason R. Levy, Elizabeth David, Thomas J. Hopkins, Christopher M. Morris et autres

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Abstract No. 78 Improvement in quality of life in patients treated for painful osseous metastases with radiofrequency ablation: the OPuS One study

Jennifer M. Levy, Esther Pérez David, Thomas J. Hopkins, Jordan L. Morris et autres

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Percutaneous Peripheral Nerve Stimulation of the Medial Branch Nerves for the Treatment of Chronic Axial Back Pain in Patients After Radiofrequency Ablation

Timothy Ray Deer, Christopher A Gilmore, Mehul J. Desai, Sean Li et autres

OBJECTIVE: Lumbar radiofrequency ablation is a commonly used intervention for chronic back pain. However, the pain typically returns, and though retreatment may be successful, the procedure involves destruction of the medial branch nerves, which denervates the multifidus. Repeated procedures typically have diminishing …

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Radiofrequency Ablation for the Palliative Treatment of Bone Metastases: Outcomes from the Multicenter OsteoCool Tumor Ablation Post-Market Study (OPuS One Study) in 100 Patients

Jason R. Levy, Thomas J. Hopkins, Jonathan M. Morris, Nam Tran et autres

PURPOSE: To evaluate the effectiveness of radiofrequency (RF) ablation as measured by change in worst pain score from baseline to 3 mo after RF ablation for the palliative treatment of painful bone metastases. MATERIALS AND METHODS: One hundred patients (mean age, 64.6 …

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Unplanned hospital admission after ambulatory surgery: a retrospective, single cohort study

M. Stephen Melton, Yi‐Ju Li, Richard J. Pollard, Zhengxi Chen et autres

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Top Ten Tips Palliative Care Clinicians Should Know About Interventional Pain and Procedures

Claudia Z. Chou, Thomas J. Hopkins, Ignacio J. Badiola, Halena M. Gazelka et autres

Pain is a common symptom for patients with advanced illness. Palliative care (PC) clinicians are experts in pharmacologic and nonpharmacologic treatment of pain and other symptoms for these patients. True multimodal pain control should include consideration of interventional procedures and pumps to …

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