Radiofrequency Ablation for the Palliative Treatment of Bone Metastases: Outcomes from the Multicenter OsteoCool Tumor Ablation Post-Market Study (OPuS One Study) in 100 Patients
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Le résumé fourni par la source
PURPOSE: To evaluate the effectiveness of radiofrequency (RF) ablation as measured by change in worst pain score from baseline to 3 mo after RF ablation for the palliative treatment of painful bone metastases. MATERIALS AND METHODS: One hundred patients (mean age, 64.6 y) underwent RF ablation for metastatic bone disease and were followed up to 6 mo. Subjects' pain and quality of life were measured before RF ablation and postoperatively by using the Brief Pain Index and European Quality of Life questionnaires. Opioid agent use and device-, procedure-, and/or therapy-related adverse events (AEs) were collected. RESULTS: Eighty-seven patients were treated for tumors involving the thoracolumbar spine and 13 for tumors located in the pelvis and/or sacrum. All ablations were technically successful, and 97% were followed by cementoplasty. Mean worst pain score decreased from 8.2 ± 1.7 at baseline to 3.5 ± 3.2 at 6 mo (n = 22; P < 0.0001 for all visits). Subjects experienced significant improvement for all visits in average pain (P < .0001), pain interference (P < .0001), and quality of life (P < .003). Four AEs were reported, of which 2 resulted in hospitalization for pneumonia and respiratory failure. All 30 deaths reported during the study were attributed to the underlying malignancy and not related to the study procedure. CONCLUSIONS: Results from this study show rapid (within 3 d) and statistically significant pain improvement with sustained long-term relief through 6 mo in patients treated with RF ablation for metastatic bone disease.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Radiofrequency Ablation for the Palliative Treatment of Bone Metastases: Outcomes from the Multicenter OsteoCool Tumor Ablation Post-Market Study (OPuS One Study) in 100 Patients
- Date Crossref
- 01/11/2020
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Northside Hospital Department of Interventional Radiology pays non établi dans la noticeÉtablissement de santé
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Duke Medical Center pays non établi dans la noticeÉtablissement de santé
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Mayo Clinic Department of Radiology pays non établi dans la noticeÉtablissement de santé
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Moffitt Cancer Center pays non établi dans la noticeÉtablissement de santé
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Sunnybrook Health Science Centre pays non établi dans la noticeÉtablissement de santé
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Health Sciences Centre pays non établi dans la noticeÉtablissement de santé
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Memorial Medical Center Department of Neurointerventional Radiology pays non établi dans la noticeÉtablissement de santé
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UMass Memorial Medical Center pays non établi dans la noticeÉtablissement de santé
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St. Jude Medical Center Department of Neurointerventional Radiology pays non établi dans la noticeÉtablissement de santé
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Renown Regional Medical Center Department of Interventional Radiology pays non établi dans la noticeÉtablissement de santé
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Emory University Department of Interventional Radiology pays non établi dans la noticeUniversité ou école supérieure
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Banner - University Medical Center Phoenix Department of Radiology pays non établi dans la noticeÉtablissement de santé
Department of Interventional Radiology — Northside Hospital, Duke Medical Center et Department of Radiology — Mayo Clinic, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.