Accès ouvert
2025
article
OpenAlex
Yunguang Li, Shijie Tang, Huan Wang, Hongwen Zhu et autres
Chemotherapy remains the primary treatment for pancreatic ductal adenocarcinoma (PDAC), but most patients ultimately develop resistance. Here, we established 260 pancreatic cancer organoid lines, followed by extensive multi-omics profiling and therapeutic sensitivity assessments. Integrated analyses uncovered 6 novel coding and 35 noncoding …
cn
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Accès ouvert
2025
article
OpenAlex
Xin‐an Liu, Carlos Aguirre, Qixing Yang, Jiayan Ren et autres
Neuroimmune signals can regulate neuronal function and affect behavior through mechanisms that are not yet fully understood. Here we investigated the action of interleukin 13 (IL-13), a cytokine that can be produced in the brain by both microglia and neurons. We show …
cn, us, lu, it
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Accès ouvert
2025
preprint
OpenAlex
Yunguang Li, Shijie Tang, Huan Wang, Hongwen Zhu et autres
Abstract Chemotherapy remains the cornerstone of pancreatic ductal adenocarcinoma (PDAC) treatment. However, most cases of PDAC finally progress to advanced chemoresistant disease. This highlights an urgent need to develop new pharmacological strategies to overcome chemotherapy resistance using clinical grade inhibitors. Here, we …
cn
(code pays fourni par la source)
Accès ouvert
2025
erratum
OpenAlex
Fei Li, Pengfei Dai, Huili Shi, Yajuan Zhang et autres
It has come to our attention that in the version of the article initially published, in Fig. 6b, the dots of the bar plot representing vehicle-treated samples were not included; in Fig. 6j, the image for vehicle-treated PP-1 cells was mistakenly reused …
cn, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Wenchen Pu, Xianyan Shen, Xin Fan, Yuanyuan Zheng et autres
Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths globally, and the need for effective systemic therapies for HCC is urgent. Our previous work reveals that Pin1 is a potential anti-HCC target, which regulates miRNA biogenesis and identifies API-1 as a …
cn, pk
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Accès ouvert
2025
article
OpenAlex
Fei Li, Pengfei Dai, Huili Shi, Yajuan Zhang et autres
Epigenetic regulation profoundly influences the fate of cancer cells and their capacity to switch between lineages by modulating essential gene expression, thereby shaping tumor heterogeneity and therapy response. In castration-resistant prostate cancer (CRPC), the intricacies behind androgen receptor (AR)-independent lineage plasticity remain …
cn, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Lanyang Gao, Yang Yang, Yue Ming, Wenrong Liu et autres
Tumor metastasis is a major contributor for mortality in patients with pancreatic ductal adenocarcinoma (PDAC). While circular RNAs (circRNAs) have emerged as pivotal regulators of tumor progression and metastasis, their functional roles in PDAC remain poorly understood. Through comprehensive circRNA profiling of …
cn
(code pays fourni par la source)
2024
article
OpenAlex
Xiaoyi Li, Qin Yu, Xinyue Hua, Juan He et autres
ABSTRACT Actin depolymerizing factors (ADFs), like other actin‐binding proteins (ABPs), are modified by phosphorylation to regulate the dynamics of the actin filaments, thereby functioning in various processes throughout the plant lifecycle. In this study, we found that the Arabidopsis thaliana cytoplasmic kinase …
cn
(code pays fourni par la source)
2024
article
OpenAlex
Juan He, Xiaoyi Li, Qin Yu, Peng Lü et autres
The polar auxin transport is required for proper plant growth and development. D6 PROTEIN KINASE (D6PK) is required for the phosphorylation of PIN-FORMED (PIN) auxin efflux carriers to regulate auxin transport, while the regulation of D6PK stabilization is still poorly understood. Here, …
cn
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Accès ouvert
2024
article
OpenAlex
Baoshan Xian, Muhammad Saad Rehmani, Yueni Fan, Xiaofeng Luo et autres
Abscisic acid (ABA) and gibberellins (GA) antagonistically mediate several biological processes, including seed germination, but the molecular mechanisms underlying ABA/GA antagonism need further investigation, particularly any role mediated by a transcription factors module. Here, we report that the DELLA protein RGL2, a …
cn
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Accès ouvert
2024
article
OpenAlex
Yanjing Zhu, Shijie Tang, Qiuyue Yuan, Jing Fu et autres
Despite considerable efforts to identify human liver cancer genomic alterations that might unveil druggable targets, the systematic translation of multiomics data remains challenging. Here, we report success in long-term culture of 64 patient-derived hepatobiliary tumor organoids (PDHOs) from a Chinese population. A …
cn
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Accès ouvert
2024
article
OpenAlex
Yuanli Zuo, Wenrong Liu, Yang Jin, Yitong Pan et autres
Motivation: Circular RNAs (circRNAs) play important roles in gene expression and their involvement in tumorigenesis is emerging. circRNA-related database is a powerful tool for researchers to investigate circRNAs. However, existing databases lack advanced platform integrating comprehensive information and analysis tools of cancer-related …
cn
(code pays fourni par la source)