Ling Qin

A first-in-human, phase I/II, open-label, multicenter, dose escalation and expansion study of lbl-034, a conditionally activated bispecific antibody targeting GPRC5D and CD3 with a 2:1 format, in patients with relapsed/refractory multiple myeloma

Xuelin Dou, Yuping Zhong, Wanhong Zhao, Ling Qin et autres

Abstract Introduction LBL-034 is a humanized IgG1 subtype asymmetric bispecific antibody targeting GPRC5D and CD3 with a 2:1 format. Its unique design features affinity optimization and steric hindrance within the anti-CD3 arm, effectively reducing off-target engagement with bystander T cells and minimizing …

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Discrepancies in Treatment Goals and Concerns Regarding Disease Management between Patients with Myeloproliferative Neoplasms and Hematologists in China: Analysis from a Multicenter Cross-Sectional Survey

Junling Zhuang, Hongxia Shi, Xiaoli Liu, Minghui Duan et autres

INTRODUCTION: This study was aimed to identify the discrepancies in treatment goals and concerns regarding disease management between patients with myeloproliferative neoplasms (MPNs) and hematologists. METHODS: A study was conducted among patients with MPNs, including polycythemia vera (PV), essential thrombocythemia (ET), and …

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The relationship and predictive efficacy of serum lipocalin-2, PDK1, NGALR and lymph node metastasis in postmenopausal endometrial cancer

Yuxia Wang, Ge Liu, Ling Qin, Ying Gao

Background: Endometrial carcinoma is a common gynecological malignancy, LNM is a crucial factor affecting the prognosis of endometrial cancer patients, with a significant impact on survival rates and treatment effectiveness. Serum lipocalin-2, PDK1, and NGALR have been found to be abnormally expressed …

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Glioblastoma Management in the Post-COVID-19 Era: Challenges, Strategies, and Adaptations

Xiaohui Ren, Ling Qin

The COVID-19 pandemic significantly disrupted glioblastoma (GBM) management, affecting its pathophysiology, diagnosis, treatment, and prognosis. GBM, an aggressive brain tumor with poor survival rates, presented unique vulnerabilities during the pandemic due to its rapid progression and patients’ compromised immunity. SARS-CoV-2 may also …

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An Uniquely Designed Asymmetric Bispecific Antibody Against GPRC5D and CD3 (LBL-034) in Patients with Relapsed/Refractory Multiple Myeloma: A Phase I/II, First in Human, Open-Label, Multicenter, Dose Escalation/Expansion Study

Ling Qin, Yuping Zhong, Dongping Huang, Haiyang Xie et autres

Introduction: LBL-034 is a humanized IgG1 subtype asymmetric bispecific antibody targeting the G protein-coupled receptor class C group 5 member D (GPRC5D) and a cluster of differentiation 3 (CD3). LBL-034 can promote the proliferation and activation of T cells by binding to …

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One-Pot Assay for Rapid Detection of Stenotrophomonas maltophilia by RPA-CRISPR/Cas12a

Jiangli Zhang, Ling Qin, Yingying Chang, Yulong He et autres

Stenotrophomonas maltophilia ( S. maltophilia, SMA) is a common opportunistic pathogen that poses a serious threat to the food industry and human health. Traditional detection methods for SMA are time-consuming, have low detection rates, require complex and expensive equipment and professional technical …

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Construction of an immune-related prognostic signature and lncRNA–miRNA–mRNA ceRNA network in acute myeloid leukemia

Ling Qin, Boya Li, Shijie Wang, Yulai Tang et autres

The progression of acute myeloid leukemia (AML) is influenced by the immune microenvironment in the bone marrow and dysregulated intracellular competing endogenous RNA (ceRNA) networks. Our study utilized data from UCSC Xena, The Cancer Genome Atlas Program, the Gene Expression Omnibus, and …

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Glioblastoma patients’ survival and its relevant risk factors during the pre-COVID-19 and post-COVID-19 pandemic: real-world cohort study in the USA and China

Ling Qin, Haoyi Li, Dao Zheng, Song Lin et autres

BACKGROUND: Although the COVID-19 pandemic has exerted potential impact on patients with glioblastomas (GBMs), it remains unclear whether the survival and its related risk factors of GBM patients would be altered or not during the period spanning from pre-COVID-19 to post-COVID-19 pandemic …

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1049P Phase Ib/II trial of envafolimab, a novel subcutaneous single-domain anti-PD-L1 monoclonal antibody, plus lenvatinib in patients with selected advanced solid tumors

Tianshu Liu, Yi Feng, Xiaoyuan Xu, Xiubao Ren et autres

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A complicated infection by cutaneous Nocardia wallacei and pulmonary Mycobacterium abscessus in a Chinese immunocompetent patient: a case report

Ling Qin, Sidan Wang, Zhifen Zheng, Wenqian Zhang et autres

Nocardiosis is an infectious disease caused by Nocardia that primarily affects immunocompromised hosts. Mycobacterium abscessus is a common opportunistic pathogen that causes disease in humans, including pulmonary and extrapulmonary infection. Nocardia spp. infection is uncommon, and infection with Nocardia wallacei and Mycobacterium …

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S216: CD47/PD-L1 BISPECIFIC ANTIBODY (IBI322) IN ANTI-PD-1 OR PD-L1 TREATMENT-RESISTANT CLASSICAL HODGKIN LYMPHOMA: A PHASE I STUDY

Huilai Zhang, Jingwei Yu, He Li, Wenbin Qian et autres

Background: IBI322 is an anti-CD47/PD-L1 bispecific antibody that blocks both the PD-1/PD-L1 and CD47/SIRP-α pathways. By an “imbalanced” design with a lower binding affinity to CD47 and higher binding affinity to PD-L1, preclinical models showed IBI322 tended to bind CD47+PD-L1+ tumor cells …

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[Clinical and genetic characteristics of young patients with myeloproliferative neoplasms].

M Y Zhang, Min Bao, Dayu Shi, H X Shi et autres

Compared with middle-aged and elderly patients, young patients with MPN had unique clinical and genetic characteristics.

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