Yimin Yang

Abstract WE422: Prognostic Value of Cardiovascular-Kidney-Metabolic Syndrome Stage 3 Components: Dallas Heart Study

Khaled Shelbaya, Yimin Yang, Victoria Lamberson, Yinun Zeleke et autres

Background: The Cardiovascular-Kidney Metabolic (CKM) Syndrome Stages are associated with heightened risk of cardiovascular diseases (CVD). However, the individual and additive impact of CKM Stage 3 (subclinical CVD) criteria on risk of incident clinical CVD is unclear. Methods: We included participants in …

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Abstract TH913: Serum Metabolomics and the Association between Social Determinants of Health and Heart Failure: The Atherosclerosis Risk in Communities (ARIC) Study

Rani Zierath, Yimin Yang, Victoria Lamberson, Brian Claggett et autres

Introduction: Adverse social determinants of health (SDOH) are associated with greater heart failure (HF) risk, but data regarding underlying biologic mechanisms are limited. Methods: Among 3,321 HF-free Atherosclerosis Risk in Communities (ARIC) study participants at baseline (1987-1989), we used exploratory factor analysis …

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Abstract 4373373: Attomolar-Sensitivity Plasma Proteomics Identifies Fat Depot-Specific Inflammatory Biomarkers Related to CKM Syndrome: The Dallas Heart Study

Fernando Giugni, Victoria Lamberson, Yimin Yang, Yinun Zeleke et autres

Introduction: Excess or dysfunctional adipose tissue contributes to cardio-kidney-metabolic (CKM) syndrome through the secretion of proinflammatory mediators. However, fat depot-specific inflammatory profiles remain poorly characterized. Aims: Identify inflammatory plasma proteins associated with fat depots and with components of Stage 2 CKM syndrome. …

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Abstract 4367492: Shared Circulating Proteins of Heart Failure and Dementia Risk: The Atherosclerosis Risk in Communities (ARIC) Study

Frans Ivan Serpa, Fernando Giugni, Victoria Lamberson, Yimin Yang et autres

Introduction: Heart failure (HF) and dementia have overlapping risk factors and bidirectional epidemiologic associations, suggesting shared biological pathways. Limited data exist regarding plasma proteins reflecting the risk of both HF and dementia. Aim: Identify plasma proteins associated with the development of both …

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Abstract 4373694: Changes in the Plasma Proteome with Acute Exercise: The Dallas Heart Study

Victoria Lamberson, Yimin Yang, Fernando Giugni, Karrie Curry et autres

Introduction Resting-state plasma proteins are predictive of exercise performance, but limited data exist regarding acute changes in the plasma proteome with exercise. Hypothesis: Prominent changes in the plasma proteome occur with acute exercise, a subset of which also relate to peak VO …

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Abstract 4367306: Non-invasive Diastolic Stress Testing in a Large Observational Cohort Study: Insights from the Dallas Heart Study

Alvin Chandra, Yimin Yang, Yinun Zeleke, Ambarish Pandey et autres

Introduction: Despite its increasing prevalence and significant morbidity/mortality in the aging population, heart failure with preserved ejection fraction (HFpEF) remains challenging to diagnose as its symptoms may occur only during exercise. In smaller studies, non-invasive diastolic stress testing has been validated in …

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Abstract 4373485: Plasma proteomics associated with diastolic reserve: The Dallas Heart Study

Yimin Yang, Victoria Lamberson, Fernando Giugni, Karrie Curry et autres

Introduction: Impairments in cardiac diastolic reserve during physiological stress characterize HFpEF and may antecede resting state abnormalities. Biomarkers associated with cardiac diastolic reserve may assist in early identification of diastolic impairment. Methods: Among community-based participants in the multi-ethnic Dallas Heart Study who …

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Abstract 4370397: Prognosis of Cardiovascular-Kidney-Metabolic (CKM) Stages: The Dallas Heart Study

Khaled Shelbaya, Yimin Yang, Victoria Lamberson, Yinun Zeleke et autres

Background: The recent AHA presidential advisory on Cardiovascular-Kidney-Metabolic Syndrome (CKM) proposed a novel staging scheme, but limited data exist regarding the associations of CKM Stages with incident cardiovascular events and mortality. Methods: We included participants in the Dallas Heart Study, a population-sampled …

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Abstract 4368885: Progression in Cardiovascular-Kidney-Metabolic (CKM) Stages Over 7 Years in Mid-Life: The Dallas Heart Study

Khaled Shelbaya, Yimin Yang, Yinun Zeleke, Victoria Lamberson et autres

Introduction: While previous studies have quantified the community prevalence of Cardiovascular-Kidney-Metabolic (CKM) Stages, limited data exist regarding the expected progression of CKM Stages in mid-life. Methods: Among participants in the population-sampled Dallas Heart Study (DHS) longitudinal cohort, we estimated the prevalence of …

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HFE related acute porphyria-like attack induced by severe influenza A pneumonia

Hongmei Yang, Dongxia Wang, Yimin Yang

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Efficacy and safety of pembrolizumab for the treatment of advanced or recurrent ovarian cancer: a meta-analysis based on single-arm studies

Xiaoguang Mi, Liming Tan, Tong Lin, Yimin Yang et autres

Objective: Ovarian cancer is a common malignant tumor of the female reproductive system, and traditional treatments are unsatisfactory due to its intraperitoneal spreading mechanism and its biologic characteristic of being prone to drug resistance. Pembrolizumab has demonstrated high objective remission and overall …

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Differential Associations of Cardiac, Pulmonary, Arterial, and Muscle Physiological Parameters and Biomarkers With the Incidence of HFpEF and HFrEF

Fernando Giugni, Yimin Yang, Brian Lee Claggett, Victoria Lamberson et autres

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