Liang Zhao

Targeting Senescence: Tianma Granule Inhibits Colorectal Cancer Progression by Modulating miR‐29a‐5p/P53 Signaling in the Tumor Microenvironment

Xiaojuan Tang, Yuan Ren, Yongmin Li, Yuan Lv et autres

Chemotherapy-induced senescence-associated tumor microenvironment (S-TME) facilitates colorectal cancer (CRC) progression. This study elucidates the mechanism by which Tianma granule (TMG), a traditional Chinese medicine formula, remodels the S-TME and inhibits CRC, specifically investigating the role of the miR-29a-5p/P53 axis. Liquid chromatography-tandem mass …

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Targeting hepatocytic TβRI ameliorates liver metastatic outcomes by revitalizing stem-like CD8+ Tex subsets

Yan Zhou, Yuanyu Tu, Junxiong You, Baogui Gao et autres

Stem-like CD8⁺ exhausted T cells (Tex) sustain antitumor immunity, whereas TGFβ signaling acts as a major immunosuppressive pathway. In patients with colorectal liver metastases, we observe that elevated TβRI expression in peri-metastatic hepatocytes correlates with poor prognosis. We therefore investigate whether disrupting …

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FAM135B Deficiency Inhibits Cytotoxic T-cell Activity in Triple-Negative Breast Cancer by Blocking the IFI16-Dependent STING Pathway

Wanmei Lin, Junze Li, Jun Wu, Junguang Liang et autres

Immune checkpoint blockade (ICB) has improved outcomes for patients with several types of cancer. However, only a minority of patients with triple-negative breast cancer (TNBC) derive benefits, and the underlying mechanisms remain largely unknown. In this study, we identified family with sequence …

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MiR-27a-5p deficiency in plasma exosomes derived from obese individuals exacerbates ventilator-induced lung injury in vitro and in vivo

Changping Gu, Yi Zhang, Liang Zhao, Yang Li et autres

BACKGROUND: Ventilator-induced lung injury (VILI) frequently occurs in obese individuals and significantly negates outcomes. Understanding mechanisms behind susceptibility of obese patients to VILI is, therefore, important. This study delved into the molecular biology mechanisms of VILI and investigated the effects of plasma …

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Table S2 from Tumor-Derived CCL16 Normalizes Tumor Vasculature through Macrophage ICAM-1 Receptor and Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Kunling Chen, Huolun Feng, Yujie Zhang, Jingyuan Pei et autres

Oligonucleotide information, related to STAR Methods.

Figure S6 from Tumor-Derived CCL16 Normalizes Tumor Vasculature through Macrophage ICAM-1 Receptor and Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Kunling Chen, Huolun Feng, Jingyuan Pei, Yuyan Xu et autres

CCL16-mediated vascular normalization through non-canonical receptor signaling.

Figure S5 from Tumor-Derived CCL16 Normalizes Tumor Vasculature through Macrophage ICAM-1 Receptor and Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Kunling Chen, Huolun Feng, Jingyuan Pei, Yuyan Xu et autres

The role of macrophage membrane receptor ICAM-1.

Figure S3 from Tumor-Derived CCL16 Normalizes Tumor Vasculature through Macrophage ICAM-1 Receptor and Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Kunling Chen, Huolun Feng, Yujie Zhang, Jingyuan Pei et autres

rCCL16 reverses immunosuppressive TME in HCC.

Figure S8 from Tumor-Derived CCL16 Normalizes Tumor Vasculature through Macrophage ICAM-1 Receptor and Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Kunling Chen, Huolun Feng, Jingyuan Pei, Yuyan Xu et autres

CCL16 degradation in the HCC microenvironment and therapeutic potential of DPP4 inhibitors.

Figure S2 from Tumor-Derived CCL16 Normalizes Tumor Vasculature through Macrophage ICAM-1 Receptor and Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Kunling Chen, Huolun Feng, Jingyuan Pei, Yuyan Xu et autres

CCL16 promotes vascular normalization in HCC.

Figure S7 from Tumor-Derived CCL16 Normalizes Tumor Vasculature through Macrophage ICAM-1 Receptor and Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Kunling Chen, Huolun Feng, Yujie Zhang, Jingyuan Pei et autres

CCL16-ICAM-1 interaction activates JAK2/STAT6-IL24 axis in promoting vascular normalization.

Figure S9 from Tumor-Derived CCL16 Normalizes Tumor Vasculature through Macrophage ICAM-1 Receptor and Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Kunling Chen, Huolun Feng, Jingyuan Pei, Yuyan Xu et autres

The effect of CCL16 on the TIME and tumor vasculature in HCC.