Zhiyong Gong

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian et autres

Liver is a central organ for lipid metabolism. Disruption of lipid homeostasis leads to lipid accumulation in hepatocytes, which is a feature of metabolic dysfunction-associated steatotic liver disease (MASLD). Mechanical force and mechanosensitive proteins have been found to play a crucial role …

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A Novel Immunoprobe Strategy Integrating Tetrahedral DNA Nanostructure and Protein A for Sensitivity Enhancement: Application in Lead Ion Detection

Xiaotong Hao, Yang Yang Li, Zhengwei Zhu, Chenyang Lu et autres

Immunochromatographic assay (ICA) has been extensively utilized for on-site detection to ensure food safety. However, maintaining the bioactivity of immunoprobes while achieving efficient antibody labeling remains a significant challenge. In this study, a novel immunoprobe was developed by integrating tetrahedral DNA nanostructure …

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Single-molecule manipulation and detection by WGM-coupled photonic nanojets

Heng Li, Zhiyong Gong, Tongfu He, Tianli Wu et autres

Optical manipulation and detection of single molecules, such as biomolecules and bacterial viruses, are crucial in single-molecule mechanics and biosensing. The interaction between light and individual molecules is weak due to the size of biomolecules (≤ 10 nm) being significantly smaller than …

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Mitigation of zearalenone-induced hepatocyte toxicity by peroxidase and laccase: insights from enzymatic detoxification study

Yutao Zhang, Yuting Zhang, Wei Ping Jia, Xingchen Song et autres

Zearalenone (ZEN), a mycotoxin present in cereals, poses significant health risks to animals and humans due to its estrogenic effects. Numerous studies on the enzymatic detoxification of ZEN have predominantly focused on reducing the parent toxin to assess the enzyme’s efficacy, yet …

Light‐Driven Micronavigators for Directional Migration of Cells

Yanan Zhao, Xiaoshuai Liu, Zhiyong Gong, Jiaqi Xu et autres

Abstract Cell migration is an essential physiological process in the life cycle of cells, playing a crucial role in cancer metastasis, neural development, and cellular immune response. However, achieving precise control of cell migration at single‐cell level is challenging due to the …

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Supramolecular Self-Assembly of High-Loaded Horseradish Peroxidase and Biorecognized Antibody into Au/Polydopamine Nanocomposites for Sensitive Immunoassay of E. Coli O157:H7 in Milk

Bolong Fang, Yuzhi Li, Xiaole Zhao, Yan Liu et autres

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A highly sensitive immunochromatographic assay for lead ions in drinking water based on antibody-oriented probe and silver enhancement

Yang Yang Li, Zhengwei Zhu, Wenli Qu, Qing Yang et autres

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Optofluidic identification of single microorganisms using fiber‐optical‐tweezer‐based Raman spectroscopy with artificial neural network (BMEMat 1/2023)

Chenghong Lin, Xiaofeng Li, Tianli Wu, Jiaqi Xu et autres

Pathogenic microorganisms that cause diseases are like the hateful monsters in Journey to the West. With strong mobility, they keep wandering everywhere, making it very difficult to identify them in a great variety of species using conventional microscopes. In article number 10.1002/bmm2.12007, …

Chemical composition of walnuts from three regions in China

Min Liu, Xueyan Wang, Yu Zhang, Lin Xu et autres

To reveal the characteristic chemicals of walnuts from different origins, we analyzed fatty acid composition, tocopherols, phytosterols and total phenolic content (TPC) of walnuts from three main producing regions in China. The results showed that walnuts were rich in polyunsaturated fatty acids, …

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Universal probe with oriented antibody to improve the immunochromatographic assay of lead ions inProcambarus clarkii

Yangyang Li, Zhengwei Zhu, Wenli Qu, Qing Yang et autres

Abstract Objectives Based on the information from the random inspection of foods by the China Food and Drug Administration in 2022, the contamination levels of lead ions are high in many edible products. Traditional methods of detecting lead ions cannot meet the …

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Photonic Nanojet‐Mediated Optogenetics

Jinghui Guo, Yong Ming Wu, Zhiyong Gong, Xixi Chen et autres

Adv. Sci. 2022, 9, 2104140 DOI: 10.1002/advs.202104140 In the original published article, there was a mistake in Figure 2I. Please find the correct Figure 2 below. The authors apologize for any inconvenience caused.

The Hepatoprotective Effect of Leonurine Hydrochloride Against Alcoholic Liver Disease Based on Transcriptomic and Metabolomic Analysis

Ke‐Jia Wu, Pin-Pin Liu, Mengyuan Chen, Mengxin Zhou et autres

Excessive alcohol consumption can eventually progress to alcoholic liver disease (ALD). The underlying mechanism of ALD toxicity is primarily associated with oxidative damage. Many alkaloids have been reported to possess potential antioxidative efficacy, while the mechanism of their hepatoprotective activity against ALD …

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