Yuting Zhang

Kv1.3 Inhibition Alleviates Diabetic Kidney Injury via Suppression of Inflammation and Fibrosis

Yuting Zhang, Ji Bian, Dorothy C.C. Wai, Raymond S. Norton et autres

Background: Kv1.3, a voltage-gated potassium ion channel, plays a crucial role in energy homeostasis through the regulation of proliferation and apoptosis. Inhibition of the Kv1.3 channel has shown beneficial effects in a range of diseases such as neuroinflammatory disorders, autoimmune diseases, and …

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Carrier rocket-inspired hydrogel microspheres targeting subchondral bone osteoclast activity alleviate osteoarthritic pain and cartilage degeneration

Zhenglin Zhu, Yüjia Luo, Pengcheng Xiao, Yi Xie et autres

BACKGROUND: Osteoarthritis (OA) represents a major global health challenge, characterized by progressive cartilage degeneration and subchondral bone remodeling, which culminate in debilitating pain and functional impairment. While recent studies have underscored the pivotal role of activated osteoclasts in the pathogenesis of OA …

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Circadian disruption exacerbates cognitive impairment via an intense neuroinflammatory reaction and alpha-synuclein deposition in a Parkinson’s disease mouse model

Rong Xin Deng, Chang Liu, Hong Jin, Yu-Lan Cao et autres

BACKGROUND: Parkinson's disease (PD) is a chronic neurodegenerative disorder marked by motor symptoms and nonmotor complications, notably cognitive impairment, which severely impairs patients' quality of life. While circadian disruption (CD) correlates with cognitive decline in PD, it remains unclear whether CD is …

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Panax notoginseng protects blood-retinal barrier by modulating microglia polarization via TLR4/MyD88/NF-κB pathway in endotoxin-induced uveitis

Meizhong Peng, Shangqiu Ning, Yan Wu, Meimei Yang et autres

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(+)-a-Longipinene alleviates murine laser-induced choroidal neovascularization: Evidence from in vivo and in vitro experiments

Manhui Zhu, Min Wu, Aimin Yang, Yuanyuan Tu et autres

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Differentiation Between Parotid Adenolymphoma and Malignant Tumor Based on Multimodal Functional MRI of Radiomics and Intratumoral Vascular ITSS Classification

Baoting Yu, Chencui Huang, Xiao-fei Fan, Dong Liu et autres

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THU-044 CCN5 promotes fibrogenic activation of hepatic stellate cells and serves as a biomarker for liver fibrosis

Yunhao Duan, Fan Ding, Xiaoli Chen, Wenrun Wu et autres

Tauroursodeoxycholic Acid Induces Liver Regeneration and Alleviates Fibrosis Through GATA3 Activation

Xiaojing Song, Jiexi Yan, Jun Chen Xu, Yongqiang Zhou et autres

Background: Liver regeneration is a critical measure of liver health and plays an essential role in inhibiting the progression of fibrotic lesions and preventing liver failure after hepatocellular carcinoma surgery. However, there are no approved drugs to address this clinical challenge. Methods: …

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Mitigation of zearalenone-induced hepatocyte toxicity by peroxidase and laccase: insights from enzymatic detoxification study

Yutao Zhang, Yuting Zhang, Wei Ping Jia, Xingchen Song et autres

Zearalenone (ZEN), a mycotoxin present in cereals, poses significant health risks to animals and humans due to its estrogenic effects. Numerous studies on the enzymatic detoxification of ZEN have predominantly focused on reducing the parent toxin to assess the enzyme’s efficacy, yet …

Relationship between apparent diffusion coefficient values and clinicopathologic features in rectal cancer: a cross-sectional study

Chunyu Zhang, Ting Lü, Hongyu Zhang, Yuting Zhang et autres

Background: The prognosis of rectal cancer is closely related to its clinicopathologic features. Accurate preoperative assessment of these features is crucial for treatment planning and prognosis prediction. The apparent diffusion coefficient (ADC), derived from diffusion-weighted imaging (DWI), has shown potential as a …

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Oridonin Preserves Retinal Pigmented Epithelial Cell Tight Junctions and Ameliorates Choroidal Neovascularization

Juming Zhu, Dongmei Ding, Tao Sun, Yuting Zhang et autres

Purpose: To investigate the role and mechanism of oridonin (ORI), a bioactive diterpenoid extracted from the Chinese herbal medicine Rabdosia rubescens, on the integrity of outer blood-retinal barrier (oBRB) during choroidal neovascularization (CNV). Methods: ARPE-19 cells were exposed to hypoxia and treated …

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Activation of gut metabolite ACSL4/LPCAT3 by microplastics in drinking water mediates ferroptosis via gut–kidney axis

Yuting Zhang, Jiali Men, Kai Yin, Yingai Zhang et autres

The environmental pollutant Benzo[a]pyrene (BaP) is commonly found in the environment, with microplastics (MPs) acting as the primary carriers of BaP into living organisms, increasing its availability in the body. However, the specific pathways and mechanisms through which MPs carrying pollutants cause …

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