Tomoyuki Honda

Clinical Significance of a Cell‐Of‐Origin‐Based Classification in Pancreatic Ductal Adenocarcinoma

Tatsuya Kikuchi, Soichiro Ako, Hironari Kato, Hideaki Kinugasa et autres

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, with limited therapeutic options and poor clinical outcomes. Although PDAC has traditionally been thought to arise from ductal epithelial cells, recent studies using genetically engineered mouse models have demonstrated that acinar …

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Genomic Characterization of a Novel Victorivirus Detected in a Sample Derived From a Human‐Biting Tick in Japan

Man Liu, Da Teng, Jiajia Wu, Sayumi Gouchi et autres

Surveillance of tick-associated viruses may contribute to our understanding of viral diversity and evolution. Here, we identified a novel victorivirus in a sample derived from a human-biting tick, Amblyomma testudinarium, in Japan. The viral sequence was identified by metatranscriptomic sequencing of total …

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[Bornavirus Disease].

Tomoyuki Honda

Bornavirus disease is a zoonotic infection transmitted from virus-infected shrews and squirrels. Although rare, the infection can rapidly progress to fatal encephalomyelitis. Magnetic resonance imaging demonstrates bilateral lesions in the basal ganglia and the limbic system. Diagnosis is established through antibody testing …

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Abstract 3888: Clinical significance of a cell-of-origin-based classification in pancreatic ductal adenocarcinoma.

Tatsuya Kikuchi, Soichiro Ako, Hideaki Kinugasa, Tomoyuki Honda et autres

Abstract (Background) Pancreatic ductal adenocarcinoma (PDAC) had been thought to arise from pancreatic ductal cells. However, recent studies using genetically engineered mouse model revealed that both pancreatic acinar and ductal cells can serve as cells of origin with distinct biological properties. However, …

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Redeployment of Archaeal ESCRT Systems Reveals Conserved Mechanisms Underlying Eukaryotic Complexity

Kishore Babu Naripogu, Yee Han Tee, Yosuke Senju, Han-Zhou Li et autres

Summary Eukaryotic ESCRT complexes remodel membranes at the plasma membrane and internal compartments, yet how these systems evolved from prokaryotic precursors functioning at the cellular membrane remains unresolved. Here, we show that ESCRT-II, ESCRT-III, VPS4, and ubiquitin from Candidatus Prometheoarchaeum syntrophicum (MK-D1), …

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Human herpesvirus 6B U65 binds to histone proteins and suppresses interferon production

Han-Zhou Li, Hirohito Ogawa, Da Teng, Yuki Okame et autres

subfamily, is a T-lymphotropic virus that causes exanthem subitum and has been implicated in neuroinflammatory conditions such as multiple sclerosis. The tegument proteins, which are characteristic of herpesviruses, play a crucial role in the envelopment of virions and evasion of host immune …

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Effect of oligosaccharyl transglycosylation on the cytotoxicity of cardiac glycoside proscillaridin A and its ability to inhibit hepatitis B virus infection

Akira Wakamatsu, Yu Fujisawa, Hiroyuki Ohashi, Takashi Kinoshita et autres

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Suppression of Borna Disease Virus Replication during Its Persistent Infection Using the CRISPR/Cas13b System

Shigenori Sasaki, Hirohito Ogawa, Hirokazu Katoh, Tomoyuki Honda

Borna disease virus (BoDV-1) is a bornavirus that infects the central nervous systems of various animal species, including humans, and causes fatal encephalitis. BoDV-1 also establishes persistent infection in neuronal cells and causes neurobehavioral abnormalities. Once neuronal cells or normal neural networks …

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HAND2 suppresses favipiravir efficacy in treatment of Borna disease virus infection

Da Teng, Keiji Ueda, Tomoyuki Honda

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SARS-CoV-2 spike receptor-binding domain is internalized and promotes protein ISGylation in human induced pluripotent stem cell-derived cardiomyocytes

Shota Okuno, Shuichiro Higo, Takumi Kondo, Mikio Shiba et autres

Although an increased risk of myocarditis has been observed after vaccination with mRNA encoding severe acute respiratory syndrome coronavirus 2 spike protein, its underlying mechanism has not been elucidated. This study investigated the direct effects of spike receptor-binding domain (S-RBD) on human …

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Roles of Human Endogenous Retroviruses and Endogenous Virus-Like Elements in Cancer Development and Innate Immunity

Hirokazu Katoh, Tomoyuki Honda

Human endogenous retroviruses (HERVs) are remnants of ancient retroviral infections in the host genome. Although mutations and silencing mechanisms impair their original role in viral replication, HERVs are believed to play roles in various biological processes. Long interspersed nuclear elements (LINEs) are …

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Cap Analysis of Gene Expression Clarifies Transcriptomic Divergence Within Monozygotic Twin Pairs

Hirokazu Katoh, Hiroaki Asai, Keiko Takemoto, Rie Tomizawa et autres

Phenotypic variation is the result of gene expression based on complex interaction between genetic and environmental factors. It is well known that genetic and environmental factors influence gene expression, but our understanding of their relative importance remains limited. To obtain a hint …

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